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Items: 1 to 20 of 267

1.

The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.

Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.

J Biol Chem. 2015 Aug 21;290(34):20827-40. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.

2.

PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs).

Barrows D, He JZ, Parsons R.

J Biol Chem. 2016 Sep 16;291(38):20042-54. doi: 10.1074/jbc.M116.723882. Epub 2016 Aug 1.

3.

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

Cash JN, Davis EM, Tesmer JJG.

Structure. 2016 May 3;24(5):730-740. doi: 10.1016/j.str.2016.02.022. Epub 2016 Apr 14.

4.

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.

Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R.

J Biol Chem. 2015 Nov 27;290(48):28915-31. doi: 10.1074/jbc.M115.668244. Epub 2015 Oct 5.

5.

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1.

Pan D, Barber MA, Hornigold K, Baker MJ, Toth JM, Oxley D, Welch HC.

J Biol Chem. 2016 Mar 18;291(12):6359-75. doi: 10.1074/jbc.M115.686592. Epub 2016 Jan 20.

6.

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ.

Nat Struct Biol. 2001 Dec;8(12):1037-41.

PMID:
11685227
7.

P-Rex1 and P-Rex2 RacGEFs and cancer.

Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA.

Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Review.

PMID:
28710285
8.

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3305-10. doi: 10.1073/pnas.1113512109. Epub 2012 Feb 13.

9.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR.

PLoS One. 2014 Jul 11;9(7):e102425. doi: 10.1371/journal.pone.0102425. eCollection 2014.

10.

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.

11.

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Worthylake DK, Rossman KL, Sondek J.

Nature. 2000 Dec 7;408(6813):682-8.

PMID:
11130063
12.

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits.

Hill K, Krugmann S, Andrews SR, Coadwell WJ, Finan P, Welch HC, Hawkins PT, Stephens LR.

J Biol Chem. 2005 Feb 11;280(6):4166-73. Epub 2004 Nov 15.

13.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.

Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.

J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16.

PMID:
30446620
14.

The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.

Xu Z, Gakhar L, Bain FE, Spies M, Fuentes EJ.

J Biol Chem. 2017 Oct 27;292(43):17777-17793. doi: 10.1074/jbc.M117.799114. Epub 2017 Sep 7.

16.

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.

Gao Y, Xing J, Streuli M, Leto TL, Zheng Y.

J Biol Chem. 2001 Dec 14;276(50):47530-41. Epub 2001 Oct 10. Erratum in: J Biol Chem. 2005 Jan 14;280(2):1704.

17.

Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells.

Nie B, Cheng N, Dinauer MC, Ye RD.

Cell Signal. 2010 May;22(5):770-82. doi: 10.1016/j.cellsig.2010.01.001. Epub 2010 Jan 13.

18.

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.

Chhatriwala MK, Betts L, Worthylake DK, Sondek J.

J Mol Biol. 2007 May 18;368(5):1307-20. Epub 2007 Feb 22.

19.

Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation.

Qian F, Le Breton GC, Chen J, Deng J, Christman JW, Wu D, Ye RD.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):768-77. doi: 10.1161/ATVBAHA.111.243675. Epub 2011 Dec 29.

20.

Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.

Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E.

J Biol Chem. 2008 Aug 8;283(32):22257-71. doi: 10.1074/jbc.M800734200. Epub 2008 May 27.

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