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Items: 1 to 20 of 118

1.

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J.

Nat Immunol. 2015 Jul;16(7):737-45. doi: 10.1038/ni.3194. Epub 2015 May 25.

PMID:
26006015
2.

Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance.

Yang S, Bansal K, Lopes J, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1833-8. doi: 10.1073/pnas.1222023110. Epub 2013 Jan 14.

3.

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS.

Nat Immunol. 2014 Mar;15(3):258-65. doi: 10.1038/ni.2820. Epub 2014 Jan 26. Erratum in: Nat Immunol. 2014 Sep;15(9):894.

4.

Identification of a novel cis-regulatory element essential for immune tolerance.

LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS.

J Exp Med. 2015 Nov 16;212(12):1993-2002. doi: 10.1084/jem.20151069. Epub 2015 Nov 2.

5.

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.

Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F.

Nat Commun. 2015 Nov 4;6:8820. doi: 10.1038/ncomms9820.

6.

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism.

Danso-Abeam D, Staats KA, Franckaert D, Van Den Bosch L, Liston A, Gray DH, Dooley J.

Eur J Immunol. 2013 Jan;43(1):75-84. doi: 10.1002/eji.201242761. Epub 2012 Dec 6.

7.

Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

Rattay K, Claude J, Rezavandy E, Matt S, Hofmann TG, Kyewski B, Derbinski J.

J Immunol. 2015 Feb 1;194(3):921-8. doi: 10.4049/jimmunol.1402694. Epub 2014 Dec 31.

8.

Mode of Tolerance Induction and Requirement for Aire Are Governed by the Cell Types That Express Self-Antigen and Those That Present Antigen.

Mouri Y, Ueda Y, Yamano T, Matsumoto M, Tsuneyama K, Kinashi T, Matsumoto M.

J Immunol. 2017 Dec 15;199(12):3959-3971. doi: 10.4049/jimmunol.1700892. Epub 2017 Nov 3.

9.

Medullary thymic epithelial cells, the indispensable player in central tolerance.

Shi Y, Zhu M.

Sci China Life Sci. 2013 May;56(5):392-8. doi: 10.1007/s11427-013-4482-4. Epub 2013 May 1. Review.

PMID:
23633070
10.

Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells.

Rattay K, Meyer HV, Herrmann C, Brors B, Kyewski B.

J Autoimmun. 2016 Feb;67:65-75. doi: 10.1016/j.jaut.2015.10.001. Epub 2015 Oct 23.

11.

Redefining thymus medulla specialization for central tolerance.

Cosway EJ, Lucas B, James KD, Parnell SM, Carvalho-Gaspar M, White AJ, Tumanov AV, Jenkinson WE, Anderson G.

J Exp Med. 2017 Nov 6;214(11):3183-3195. doi: 10.1084/jem.20171000. Epub 2017 Aug 22.

12.

Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells.

St-Pierre C, Trofimov A, Brochu S, Lemieux S, Perreault C.

J Immunol. 2015 Jul 15;195(2):498-506. doi: 10.4049/jimmunol.1500558. Epub 2015 Jun 1.

13.

Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction.

Pezzi N, Assis AF, Cotrim-Sousa LC, Lopes GS, Mosella MS, Lima DS, Bombonato-Prado KF, Passos GA.

Mol Immunol. 2016 Sep;77:157-73. doi: 10.1016/j.molimm.2016.08.003. Epub 2016 Aug 8.

PMID:
27505711
14.

DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells.

Wu G, Hirabayashi K, Sato S, Akiyama N, Akiyama T, Shiota K, Yagi S.

BMC Immunol. 2012 Nov 2;13:58. doi: 10.1186/1471-2172-13-58.

15.

An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression.

Ucar O, Tykocinski LO, Dooley J, Liston A, Kyewski B.

Eur J Immunol. 2013 Jul;43(7):1769-78. doi: 10.1002/eji.201343343. Epub 2013 May 17.

16.

Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice.

Milićević Z, Milićević NM, Laan M, Peterson P, Kisand K, Scott HS, Westermann J.

Immunol Cell Biol. 2010 Jan;88(1):50-6. doi: 10.1038/icb.2009.55. Epub 2009 Sep 1.

PMID:
19721455
17.

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.

Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Mouri Y, Matsumoto M.

J Exp Med. 2008 Nov 24;205(12):2827-38. doi: 10.1084/jem.20080046. Epub 2008 Nov 17.

18.

Transcriptional programs that control expression of the autoimmune regulator gene Aire.

Herzig Y, Nevo S, Bornstein C, Brezis MR, Ben-Hur S, Shkedy A, Eisenberg-Bord M, Levi B, Delacher M, Goldfarb Y, David E, Weinberger L, Viukov S, Ben-Dor S, Giraud M, Hanna JH, Breiling A, Lyko F, Amit I, Feuerer M, Abramson J.

Nat Immunol. 2017 Feb;18(2):161-172. doi: 10.1038/ni.3638. Epub 2016 Dec 12.

PMID:
27941786
19.

Modulation of Aire regulates the expression of tissue-restricted antigens.

Kont V, Laan M, Kisand K, Merits A, Scott HS, Peterson P.

Mol Immunol. 2008 Jan;45(1):25-33. Epub 2007 Jun 28.

20.

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance.

Khan IS, Mouchess ML, Zhu ML, Conley B, Fasano KJ, Hou Y, Fong L, Su MA, Anderson MS.

J Exp Med. 2014 May 5;211(5):761-8. doi: 10.1084/jem.20131889. Epub 2014 Apr 21.

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