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Items: 1 to 20 of 85

1.

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases.

Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M.

Trends Pharmacol Sci. 2015 Feb;36(2):72-7. doi: 10.1016/j.tips.2014.12.004. Epub 2015 Jan 27. Review.

2.

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins.

Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M.

Cell Rep. 2013 Nov 14;5(3):781-90. doi: 10.1016/j.celrep.2013.09.043. Epub 2013 Oct 31.

3.

A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.

Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4753-8. doi: 10.1073/pnas.1516604113. Epub 2016 Apr 11.

4.

Sequestration of cellular interacting partners by protein aggregates: implication in a loss-of-function pathology.

Yang H, Hu HY.

FEBS J. 2016 Oct;283(20):3705-3717. doi: 10.1111/febs.13722. Epub 2016 May 6. Review.

5.

Shaping proteostasis at the cellular, tissue, and organismal level.

Sala AJ, Bott LC, Morimoto RI.

J Cell Biol. 2017 May 1;216(5):1231-1241. doi: 10.1083/jcb.201612111. Epub 2017 Apr 11. Review.

6.

Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes.

Sin O, Nollen EA.

Cell Mol Life Sci. 2015 Nov;72(21):4027-47. doi: 10.1007/s00018-015-1985-0. Epub 2015 Jul 21. Review.

7.

Neurodegenerative disorders: dysregulation of a carefully maintained balance?

Swart C, Haylett W, Kinnear C, Johnson G, Bardien S, Loos B.

Exp Gerontol. 2014 Oct;58:279-91. doi: 10.1016/j.exger.2014.09.003. Epub 2014 Sep 9. Review.

PMID:
25219768
8.

In vivo aspects of protein folding and quality control.

Balchin D, Hayer-Hartl M, Hartl FU.

Science. 2016 Jul 1;353(6294):aac4354. doi: 10.1126/science.aac4354. Review.

PMID:
27365453
9.

Layers of structure and function in protein aggregation.

Tanaka M, Komi Y.

Nat Chem Biol. 2015 Jun;11(6):373-7. doi: 10.1038/nchembio.1818. No abstract available.

PMID:
25978986
10.

Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.

Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R.

Aging Cell. 2015 Feb;14(1):35-48. doi: 10.1111/acel.12296. Epub 2014 Dec 16.

11.

Oxidative stress and protein aggregation during biological aging.

Squier TC.

Exp Gerontol. 2001 Sep;36(9):1539-50. Review.

PMID:
11525876
12.

The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease.

Duncan EJ, Cheetham ME, Chapple JP, van der Spuy J.

Subcell Biochem. 2015;78:243-73. doi: 10.1007/978-3-319-11731-7_12. Review.

PMID:
25487025
13.

Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions.

Kumar S, Thangakani AM, Nagarajan R, Singh SK, Velmurugan D, Gromiha MM.

Sci Rep. 2016 Feb 29;6:22258. doi: 10.1038/srep22258.

14.

Aggregopathy in neurodegenerative diseases: mechanisms and therapeutic implication.

Dohm CP, Kermer P, Bähr M.

Neurodegener Dis. 2008;5(6):321-38. doi: 10.1159/000119459. Epub 2008 Feb 29. Review.

PMID:
18309232
15.

Chaperones in Neurodegeneration.

Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ.

J Neurosci. 2015 Oct 14;35(41):13853-9. doi: 10.1523/JNEUROSCI.2600-15.2015. Review.

16.

Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases.

Breydo L, Uversky VN.

Metallomics. 2011 Nov;3(11):1163-80. doi: 10.1039/c1mt00106j. Epub 2011 Aug 25. Review.

PMID:
21869995
17.

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.

Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU, Vabulas RM.

Cell. 2011 Jan 7;144(1):67-78. doi: 10.1016/j.cell.2010.11.050.

18.

Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation.

Herrera F, Gonçalves S, Outeiro TF.

Methods Enzymol. 2012;506:157-74. doi: 10.1016/B978-0-12-391856-7.00033-0.

PMID:
22341224
19.

Proteostasis impairment in protein-misfolding and -aggregation diseases.

Hipp MS, Park SH, Hartl FU.

Trends Cell Biol. 2014 Sep;24(9):506-14. doi: 10.1016/j.tcb.2014.05.003. Epub 2014 Jun 16. Review.

PMID:
24946960
20.

Strategies for the inhibition of protein aggregation in human diseases.

Bartolini M, Andrisano V.

Chembiochem. 2010 May 17;11(8):1018-35. doi: 10.1002/cbic.200900666. Review.

PMID:
20401887

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