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Items: 1 to 20 of 85

1.

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M; Alzheimer's Disease Genetics Consortium, Mayeux R, Pericak-Vance M, Haines J, Farrer LA, Schellenberg GD, Goate A, Behrens TW, Cruchaga C, Watts RJ, Graham RR.

Nat Med. 2014 Dec;20(12):1452-7. doi: 10.1038/nm.3736. Epub 2014 Nov 24.

2.

An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.

Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M.

J Biol Chem. 2016 Jun 3;291(23):12282-93. doi: 10.1074/jbc.M115.698092. Epub 2016 Apr 11.

3.

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.

Jiao B, Liu X, Tang B, Hou L, Zhou L, Zhang F, Zhou Y, Guo J, Yan X, Shen L.

Neurobiol Aging. 2014 Oct;35(10):2422.e9-2422.e11. doi: 10.1016/j.neurobiolaging.2014.04.025. Epub 2014 May 1.

PMID:
24866402
4.

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells.

Tsukamoto E, Hashimoto Y, Kanekura K, Niikura T, Aiso S, Nishimoto I.

J Neurosci Res. 2003 Sep 1;73(5):627-36.

PMID:
12929130
5.

Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.

Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE.

Ann Neurol. 2009 Mar;65(3):294-303. doi: 10.1002/ana.21578.

6.

The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer's Disease.

Sun JH, Wang HF, Zhu XC, Yu WJ, Tan CC, Jiang T, Tan MS, Tan L, Yu JT; Alzheimer’s Disease Neuroimaging Initiative.

Mol Neurobiol. 2016 Dec;53(10):6759-6767. Epub 2015 Dec 11.

PMID:
26660111
7.

Tyk2/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer's disease.

Wan J, Fu AK, Ip FC, Ng HK, Hugon J, Page G, Wang JH, Lai KO, Wu Z, Ip NY.

J Neurosci. 2010 May 19;30(20):6873-81. doi: 10.1523/JNEUROSCI.0519-10.2010.

8.

Spatial Memory Impairment is Associated with Intraneural Amyloid-β Immunoreactivity and Dysfunctional Arc Expression in the Hippocampal-CA3 Region of a Transgenic Mouse Model of Alzheimer's Disease.

Morin JP, Cerón-Solano G, Velázquez-Campos G, Pacheco-López G, Bermúdez-Rattoni F, Díaz-Cintra S.

J Alzheimers Dis. 2016;51(1):69-79. doi: 10.3233/JAD-150975.

PMID:
26836189
9.

Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.

Coissieux MM, Tomsic J, Castets M, Hampel H, Tuupanen S, Andrieu N, Comeras I, Drouet Y, Lasset C, Liyanarachchi S, Mazelin L, Puisieux A, Saurin JC, Scoazec JY, Wang Q, Aaltonen L, Tanner SM, de la Chapelle A, Bernet A, Mehlen P.

Gastroenterology. 2011 Dec;141(6):2039-46. doi: 10.1053/j.gastro.2011.08.041. Epub 2011 Sep 3.

10.

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils.

Poduslo JF, Howell KG, Olson NC, Ramirez-Alvarado M, Kandimalla KK.

Biochemistry. 2012 May 15;51(19):3993-4003. doi: 10.1021/bi300275g. Epub 2012 May 7.

PMID:
22545812
11.

unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.

Auger ML, Schmidt ER, Manitt C, Dal-Bo G, Pasterkamp RJ, Flores C.

Eur J Neurosci. 2013 Sep;38(6):2853-63. doi: 10.1111/ejn.12270. Epub 2013 Jun 5.

PMID:
23738838
12.

A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity.

Hashimoto Y, Matsuoka M.

J Neurochem. 2014 Jul;130(2):291-300. doi: 10.1111/jnc.12717. Epub 2014 Apr 10.

13.

Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.

Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG.

J Neurosci. 2000 Dec 1;20(23):8717-26.

14.
15.

Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.

Dodson SE, Andersen OM, Karmali V, Fritz JJ, Cheng D, Peng J, Levey AI, Willnow TE, Lah JJ.

J Neurosci. 2008 Nov 26;28(48):12877-86. doi: 10.1523/JNEUROSCI.4582-08.2008.

16.

Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain.

Abad MA, Enguita M, DeGregorio-Rocasolano N, Ferrer I, Trullas R.

J Neurosci. 2006 Dec 6;26(49):12735-47.

17.

The genetics of Alzheimer's disease.

Chai CK.

Am J Alzheimers Dis Other Demen. 2007 Feb-Mar;22(1):37-41. Review.

PMID:
17534000
18.

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.

Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M, Nishimoto I.

J Neurochem. 2004 Aug;90(3):549-58.

19.

Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques.

Shin MK, Kim HG, Baek SH, Jung WR, Park DI, Park JS, Jo DG, Kim KL.

Neurobiol Aging. 2014 May;35(5):990-1001. doi: 10.1016/j.neurobiolaging.2013.10.091. Epub 2013 Oct 29.

PMID:
24268884
20.

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.

Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C.

Brain. 2015 Jun;138(Pt 6):1722-37. doi: 10.1093/brain/awv024. Epub 2015 Mar 1.

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