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Items: 1 to 20 of 89

1.

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease.

Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L.

Front Aging Neurosci. 2014 Jul 30;6:190. doi: 10.3389/fnagi.2014.00190. eCollection 2014.

2.

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease.

Sofola O, Kerr F, Rogers I, Killick R, Augustin H, Gandy C, Allen MJ, Hardy J, Lovestone S, Partridge L.

PLoS Genet. 2010 Sep 2;6(9):e1001087. doi: 10.1371/journal.pgen.1001087. Erratum in: PLoS Genet. 2012 Jan;8(1). doi: 10.1371/annotation/baa8a2a9-130b-4959-b6fb-6f786fd02826.

3.

The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.

Lee S, Bang SM, Hong YK, Lee JH, Jeong H, Park SH, Liu QF, Lee IS, Cho KS.

Dis Model Mech. 2016 Mar;9(3):295-306. doi: 10.1242/dmm.018069. Epub 2015 Dec 10.

4.

Ageing increases vulnerability to aβ42 toxicity in Drosophila.

Rogers I, Kerr F, Martinez P, Hardy J, Lovestone S, Partridge L.

PLoS One. 2012;7(7):e40569. doi: 10.1371/journal.pone.0040569. Epub 2012 Jul 12.

5.

Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology.

Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S.

Appl Biochem Biotechnol. 2017 Nov;183(3):853-866. doi: 10.1007/s12010-017-2468-6. Epub 2017 Apr 17.

PMID:
28417423
6.

TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila.

Sun M, Zhao Y, Han M, Zhang B, Zhang X, Zhang Q, Lim NK, Wang WA, Huang FD.

J Alzheimers Dis. 2018;65(3):1001-1010. doi: 10.3233/JAD-170907.

PMID:
30103315
7.

Modeling the complex pathology of Alzheimer's disease in Drosophila.

Fernandez-Funez P, de Mena L, Rincon-Limas DE.

Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Epub 2015 May 27. Review.

8.

A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain.

Belfiori-Carrasco LF, Marcora MS, Bocai NI, Ceriani MF, Morelli L, Castaño EM.

Front Aging Neurosci. 2017 Mar 14;9:61. doi: 10.3389/fnagi.2017.00061. eCollection 2017.

9.

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.

Lang M, Fan Q, Wang L, Zheng Y, Xiao G, Wang X, Wang W, Zhong Y, Zhou B.

Neurobiol Aging. 2013 Nov;34(11):2604-12. doi: 10.1016/j.neurobiolaging.2013.05.029. Epub 2013 Jul 2.

10.

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.

Stokin GB, Almenar-Queralt A, Gunawardena S, Rodrigues EM, Falzone T, Kim J, Lillo C, Mount SL, Roberts EA, McGowan E, Williams DS, Goldstein LS.

Hum Mol Genet. 2008 Nov 15;17(22):3474-86. doi: 10.1093/hmg/ddn240. Epub 2008 Aug 11.

11.
12.

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.

Armato U, Chiarini A, Chakravarthy B, Chioffi F, Pacchiana R, Colarusso E, Whitfield JF, Dal Prà I.

Biochim Biophys Acta. 2013 Oct;1832(10):1634-52. doi: 10.1016/j.bbadis.2013.04.020. Epub 2013 Apr 26.

13.

Low-dose ionizing radiation alleviates Aβ42-induced cell death via regulating AKT and p38 pathways in Drosophila Alzheimer's disease models.

Hwang S, Jeong H, Hong EH, Joo HM, Cho KS, Nam SY.

Biol Open. 2019 Feb 11;8(2). pii: bio036657. doi: 10.1242/bio.036657.

14.
15.

Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.

Iijima-Ando K, Hearn SA, Shenton C, Gatt A, Zhao L, Iijima K.

PLoS One. 2009 Dec 15;4(12):e8310. doi: 10.1371/journal.pone.0008310.

16.

The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.

Zhao J, O'Connor T, Vassar R.

J Neuroinflammation. 2011 Nov 2;8:150. doi: 10.1186/1742-2094-8-150.

17.

Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain.

Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH.

J Neurochem. 2016 Aug;138(4):525-31. doi: 10.1111/jnc.13688. Epub 2016 Jul 1.

18.
19.

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila.

Iijima K, Chiang HC, Hearn SA, Hakker I, Gatt A, Shenton C, Granger L, Leung A, Iijima-Ando K, Zhong Y.

PLoS One. 2008 Feb 27;3(2):e1703. doi: 10.1371/journal.pone.0001703.

20.

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T.

J Neurosci. 2016 Mar 30;36(13):3848-59. doi: 10.1523/JNEUROSCI.3757-15.2016.

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