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Items: 1 to 20 of 77

1.

A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.

Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J.

Cell Metab. 2014 Sep 2;20(3):499-511. doi: 10.1016/j.cmet.2014.06.008. Epub 2014 Jul 17.

2.

Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance.

Ye L, Liang S, Guo C, Yu X, Zhao J, Zhang H, Shang W.

Life Sci. 2016 Dec 1;166:82-91. doi: 10.1016/j.lfs.2016.09.025. Epub 2016 Oct 1.

PMID:
27702567
3.

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation.

Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ.

Science. 2013 Jan 11;339(6116):218-22. doi: 10.1126/science.1227568. Epub 2012 Dec 6.

4.

A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.

Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B.

Circulation. 2012 Jun 12;125(23):2892-903. doi: 10.1161/CIRCULATIONAHA.111.087817. Epub 2012 May 11.

PMID:
22580331
5.

CTLA-4Ig immunotherapy of obesity-induced insulin resistance by manipulation of macrophage polarization in adipose tissues.

Fujii M, Inoguchi T, Batchuluun B, Sugiyama N, Kobayashi K, Sonoda N, Takayanagi R.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):103-9. doi: 10.1016/j.bbrc.2013.07.034. Epub 2013 Jul 18.

PMID:
23872146
6.

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity.

Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J.

Cell Metab. 2016 Apr 12;23(4):685-98. doi: 10.1016/j.cmet.2016.03.002. Epub 2016 Mar 31.

7.

PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway.

Nakamura K, Johnson GL.

J Biol Chem. 2003 Sep 26;278(39):36989-92. Epub 2003 Aug 11.

8.
9.

Protein Inhibitor of Activated STAT 1 (PIAS1) Protects Against Obesity-Induced Insulin Resistance by Inhibiting Inflammation Cascade in Adipose Tissue.

Liu Y, Ge X, Dou X, Guo L, Liu Y, Zhou SR, Wei XB, Qian SW, Huang HY, Xu CJ, Jia WP, Dang YJ, Li X, Tang QQ.

Diabetes. 2015 Dec;64(12):4061-74. doi: 10.2337/db15-0278. Epub 2015 Aug 31.

10.

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling.

Kennedy DJ, Kuchibhotla S, Westfall KM, Silverstein RL, Morton RE, Febbraio M.

Cardiovasc Res. 2011 Feb 15;89(3):604-13. doi: 10.1093/cvr/cvq360. Epub 2010 Nov 18.

11.

Macrophage migration inhibitory factor deficiency ameliorates high-fat diet induced insulin resistance in mice with reduced adipose inflammation and hepatic steatosis.

Finucane OM, Reynolds CM, McGillicuddy FC, Harford KA, Morrison M, Baugh J, Roche HM.

PLoS One. 2014 Nov 20;9(11):e113369. doi: 10.1371/journal.pone.0113369. eCollection 2014.

13.

Thalidomide controls adipose tissue inflammation associated with high-fat diet-induced obesity in mice.

Nakamitsu PZ, Compri CM, de Fraia Pinto L, Gotardo ÉM, de Oliveira CC, Ribeiro ML, Pedrazzoli J Jr, Gambero A.

Endocr Metab Immune Disord Drug Targets. 2015;15(2):151-8.

PMID:
25441253
14.

MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.

Ballak DB, van Essen P, van Diepen JA, Jansen H, Hijmans A, Matsuguchi T, Sparrer H, Tack CJ, Netea MG, Joosten LA, Stienstra R.

PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.

15.

Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity.

Woo SL, Xu H, Li H, Zhao Y, Hu X, Zhao J, Guo X, Guo T, Botchlett R, Qi T, Pei Y, Zheng J, Xu Y, An X, Chen L, Chen L, Li Q, Xiao X, Huo Y, Wu C.

PLoS One. 2014 Mar 17;9(3):e91111. doi: 10.1371/journal.pone.0091111. eCollection 2014.

16.

A novel benzenediamine derivative FC98 reduces insulin resistance in high fat diet-induced obese mice by suppression of metaflammation.

Chen C, Zhang W, Shi H, Zhuo Y, Yang G, Zhang A, Hou Y, Xiang Tan R, Li E.

Eur J Pharmacol. 2015 Aug 15;761:298-308. doi: 10.1016/j.ejphar.2015.06.021. Epub 2015 Jun 16.

PMID:
26086863
17.

Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice.

Kwok KHM, Cheng KKY, Hoo RLC, Ye D, Xu A, Lam KSL.

Clin Sci (Lond). 2016 Nov 1;130(22):2087-2100. doi: 10.1042/CS20160465. Epub 2016 Aug 10.

PMID:
27512097
18.

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.

Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D.

J Clin Invest. 2007 Oct;117(10):2877-88.

19.

Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization.

Eguchi J, Kong X, Tenta M, Wang X, Kang S, Rosen ED.

Diabetes. 2013 Oct;62(10):3394-403. doi: 10.2337/db12-1327. Epub 2013 Jul 8.

20.

Inflammatory and anti-inflammatory states of adipose tissue in transgenic mice bearing a single TCR.

Matsumoto A, Taniguchi K, Takeda N, Yamamura KI, Arai S, Miyazaki T.

Int Immunol. 2017 Jan 1;29(1):21-30. doi: 10.1093/intimm/dxx003.

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