Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 162

1.

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma.

Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W.

Mol Cancer Ther. 2014 Jul;13(7):1873-81. doi: 10.1158/1535-7163.MCT-13-0997. Epub 2014 May 7.

2.

Negative regulation of Hedgehog signaling by liver X receptors.

Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F.

Mol Endocrinol. 2009 Oct;23(10):1532-43. doi: 10.1210/me.2008-0453. Epub 2009 Jul 16.

3.

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma.

Blotta S, Jakubikova J, Calimeri T, Roccaro AM, Amodio N, Azab AK, Foresta U, Mitsiades CS, Rossi M, Todoerti K, Molica S, Morabito F, Neri A, Tagliaferri P, Tassone P, Anderson KC, Munshi NC.

Blood. 2012 Dec 13;120(25):5002-13. doi: 10.1182/blood-2011-07-368142. Epub 2012 Jul 20.

4.

Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol.

Wang F, Stappenbeck F, Matsui W, Parhami F.

J Cell Biochem. 2017 Mar;118(3):499-509. doi: 10.1002/jcb.25668. Epub 2016 Sep 21.

5.

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

Noghero A, Perino A, Seano G, Saglio E, Lo Sasso G, Veglio F, Primo L, Hirsch E, Bussolino F, Morello F.

Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2280-8. doi: 10.1161/ATVBAHA.112.250621. Epub 2012 Jun 21.

6.

Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

You M, Varona-Santos J, Singh S, Robbins DJ, Savaraj N, Nguyen DM.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):508-16. doi: 10.1016/j.jtcvs.2013.08.035. Epub 2013 Oct 4.

7.

Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.

Gruber W, Peer E, Elmer DP, Sternberg C, Tesanovic S, Del Burgo P, Coni S, Canettieri G, Neureiter D, Bartz R, Kohlhof H, Vitt D, Aberger F.

Int J Cancer. 2018 Mar 1;142(5):968-975. doi: 10.1002/ijc.31117. Epub 2017 Nov 6.

8.

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

Benvenuto M, Masuelli L, De Smaele E, Fantini M, Mattera R, Cucchi D, Bonanno E, Di Stefano E, Frajese GV, Orlandi A, Screpanti I, Gulino A, Modesti A, Bei R.

Oncotarget. 2016 Feb 23;7(8):9250-70. doi: 10.18632/oncotarget.7062.

9.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton JA.

Oncotarget. 2011 Aug;2(8):638-45.

10.

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.

Peacock CD, Wang Q, Gesell GS, Corcoran-Schwartz IM, Jones E, Kim J, Devereux WL, Rhodes JT, Huff CA, Beachy PA, Watkins DN, Matsui W.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4048-53. Epub 2007 Feb 27.

11.

Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in ApoE-deficient mice.

Chen Y, Duan Y, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao RQ, Xiang R, Hajjar DP, Han J.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):948-59. doi: 10.1161/ATVBAHA.114.305116. Epub 2015 Feb 19.

PMID:
25810299
12.

MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway.

Xu Z, Huang C, Hao D.

Oncol Rep. 2017 Feb;37(2):1261-1269. doi: 10.3892/or.2016.5304. Epub 2016 Dec 8.

PMID:
27959416
13.

Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation.

Uhmann A, Niemann H, Lammering B, Henkel C, Hess I, Nitzki F, Fritsch A, Prüfer N, Rosenberger A, Dullin C, Schraepler A, Reifenberger J, Schweyer S, Pietsch T, Strutz F, Schulz-Schaeffer W, Hahn H.

Mol Cancer Ther. 2011 Nov;10(11):2179-88. doi: 10.1158/1535-7163.MCT-11-0422. Epub 2011 Aug 30.

14.

Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ.

Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3.

15.

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E.

Int J Oncol. 2012 Nov;41(5):1751-61. doi: 10.3892/ijo.2012.1599. Epub 2012 Aug 22.

16.

Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.

Pascual-García M, Carbó JM, León T, Matalonga J, Out R, Van Berkel T, Sarrias MR, Lozano F, Celada A, Valledor AF.

J Immunol. 2011 Apr 15;186(8):4656-67. doi: 10.4049/jimmunol.1000585. Epub 2011 Mar 11.

17.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.

J Hepatol. 2014 Jan;60(1):143-51. doi: 10.1016/j.jhep.2013.08.012. Epub 2013 Aug 23.

PMID:
23978713
18.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.

19.

Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo.

Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, Wu H.

Cancer Lett. 2013 Oct 10;339(2):185-94. doi: 10.1016/j.canlet.2013.06.010. Epub 2013 Jun 18.

PMID:
23791879
20.

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4838-43. doi: 10.1073/pnas.0712216105. Epub 2008 Mar 21.

Supplemental Content

Support Center