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Items: 1 to 20 of 111

1.

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis.

Sales KU, Friis S, Konkel JE, Godiksen S, Hatakeyama M, Hansen KK, Rogatto SR, Szabo R, Vogel LK, Chen W, Gutkind JS, Bugge TH.

Oncogene. 2015 Jan 15;34(3):346-56. doi: 10.1038/onc.2013.563. Epub 2014 Jan 27.

2.

Protease-activated Receptor-2 (PAR-2)-mediated Nf-κB Activation Suppresses Inflammation-associated Tumor Suppressor MicroRNAs in Oral Squamous Cell Carcinoma.

Johnson JJ, Miller DL, Jiang R, Liu Y, Shi Z, Tarwater L, Williams R, Balsara R, Sauter ER, Stack MS.

J Biol Chem. 2016 Mar 25;291(13):6936-45. doi: 10.1074/jbc.M115.692640. Epub 2016 Feb 2.

3.

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.

List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, Burke B, Nielsen BS, Gutkind JS, Bugge TH.

Genes Dev. 2005 Aug 15;19(16):1934-50.

4.

Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer.

Bocheva G, Rattenholl A, Kempkes C, Goerge T, Lin CY, D'Andrea MR, Ständer S, Steinhoff M.

J Invest Dermatol. 2009 Jul;129(7):1816-23. doi: 10.1038/jid.2008.449. Epub 2009 Feb 26.

5.

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase.

Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo AA, Gutkind JS, Bugge TH.

Oncogene. 2011 Apr 28;30(17):2003-16. doi: 10.1038/onc.2010.586. Epub 2011 Jan 10.

6.

Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.

Kanemaru A, Yamamoto K, Kawaguchi M, Fukushima T, Lin CY, Johnson MD, Camerer E, Kataoka H.

Int J Cancer. 2017 Jan 1;140(1):130-141. doi: 10.1002/ijc.30426. Epub 2016 Sep 23.

7.

Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors.

Sales KU, Friis S, Abusleme L, Moutsopoulos NM, Bugge TH.

Oncogene. 2015 Aug 27;34(35):4664-72. doi: 10.1038/onc.2014.391. Epub 2014 Dec 8.

8.

Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis.

Seitz I, Hess S, Schulz H, Eckl R, Busch G, Montens HP, Brandl R, Seidl S, Schömig A, Ott I.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):769-75. Epub 2007 Jan 25.

PMID:
17255532
9.

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling.

Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E.

Blood. 2016 Jun 23;127(25):3260-9. doi: 10.1182/blood-2015-11-683110. Epub 2016 Apr 25.

10.

Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.

Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD.

Arthritis Rheum. 2010 Jul;62(7):1955-66. doi: 10.1002/art.27476.

11.

RalA suppresses early stages of Ras-induced squamous cell carcinoma progression.

Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA.

Oncogene. 2010 Jan 7;29(1):45-55. doi: 10.1038/onc.2009.307. Epub 2009 Oct 5.

13.

PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES, IL-6, eotaxin or TARC expression in nasal epithelium.

Rudack C, Steinhoff M, Mooren F, Buddenkotte J, Becker K, von Eiff C, Sachse F.

Clin Exp Allergy. 2007 Jul;37(7):1009-22.

PMID:
17581194
14.

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

Bardou O, Menou A, François C, Duitman JW, von der Thüsen JH, Borie R, Sales KU, Mutze K, Castier Y, Sage E, Liu L, Bugge TH, Fairlie DP, Königshoff M, Crestani B, Borensztajn KS.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):847-60. doi: 10.1164/rccm.201502-0299OC.

15.
16.

Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.

Driesbaugh KH, Buzza MS, Martin EW, Conway GD, Kao JP, Antalis TM.

J Biol Chem. 2015 Feb 6;290(6):3529-41. doi: 10.1074/jbc.M114.628560. Epub 2014 Dec 17.

17.

Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibacterium acnes.

Lee SE, Kim JM, Jeong SK, Jeon JE, Yoon HJ, Jeong MK, Lee SH.

Arch Dermatol Res. 2010 Dec;302(10):745-56. doi: 10.1007/s00403-010-1074-z. Epub 2010 Aug 10.

18.

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.

Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E.

Cancer Cell. 2007 Oct;12(4):313-27.

19.

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.

Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH.

PLoS Genet. 2012;8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.

20.

Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation.

Wang H, Moreau F, Hirota CL, MacNaughton WK.

FASEB J. 2010 Jun;24(6):1971-80. doi: 10.1096/fj.09-137646. Epub 2010 Jan 11.

PMID:
20065107

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