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Items: 1 to 20 of 87

1.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

Sanidas I, Polytarchou C, Hatziapostolou M, Ezell SA, Kottakis F, Hu L, Guo A, Xie J, Comb MJ, Iliopoulos D, Tsichlis PN.

Mol Cell. 2014 Feb 20;53(4):577-90. doi: 10.1016/j.molcel.2013.12.018. Epub 2014 Jan 23.

2.

AKT isoform-specific signals regulate RNA processing in lung cancer.

[No authors listed]

Cancer Discov. 2014 Mar;4(3):OF17. doi: 10.1158/2159-8290.CD-RW2014-028. Epub 2014 Feb 6.

3.

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

Yoh SM, Lucas JS, Jones KA.

Genes Dev. 2008 Dec 15;22(24):3422-34. doi: 10.1101/gad.1720008.

4.

Opposing functions of Akt isoforms in lung tumor initiation and progression.

Linnerth-Petrik NM, Santry LA, Petrik JJ, Wootton SK.

PLoS One. 2014 Apr 10;9(4):e94595. doi: 10.1371/journal.pone.0094595. eCollection 2014.

5.

Akt-ivation of RNA splicing.

Lee G, Blenis J.

Mol Cell. 2014 Feb 20;53(4):519-20. doi: 10.1016/j.molcel.2014.02.010.

6.

Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.

Grabinski N, Bartkowiak K, Grupp K, Brandt B, Pantel K, Jücker M.

Cell Signal. 2011 Dec;23(12):1952-60. doi: 10.1016/j.cellsig.2011.07.003. Epub 2011 Jul 12.

PMID:
21777670
7.

Interplay between estrogen receptor and AKT in estradiol-induced alternative splicing.

Bhat-Nakshatri P, Song EK, Collins NR, Uversky VN, Dunker AK, O'Malley BW, Geistlinger TR, Carroll JS, Brown M, Nakshatri H.

BMC Med Genomics. 2013 Jun 11;6:21. doi: 10.1186/1755-8794-6-21.

8.

Small molecule amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells.

Chang JG, Yang DM, Chang WH, Chow LP, Chan WL, Lin HH, Huang HD, Chang YS, Hung CH, Yang WK.

PLoS One. 2011;6(6):e18643. doi: 10.1371/journal.pone.0018643. Epub 2011 Jun 9.

9.

Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.

de Almeida SF, Grosso AR, Koch F, Fenouil R, Carvalho S, Andrade J, Levezinho H, Gut M, Eick D, Gut I, Andrau JC, Ferrier P, Carmo-Fonseca M.

Nat Struct Mol Biol. 2011 Jul 26;18(9):977-83. doi: 10.1038/nsmb.2123.

PMID:
21792193
10.

AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice.

Grabinski N, Möllmann K, Milde-Langosch K, Müller V, Schumacher U, Brandt B, Pantel K, Jücker M.

Cell Signal. 2014 May;26(5):1021-9. doi: 10.1016/j.cellsig.2014.01.018. Epub 2014 Jan 24.

PMID:
24463007
11.

AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans.

Haslinger P, Haider S, Sonderegger S, Otten JV, Pollheimer J, Whitley G, Knöfler M.

Biol Reprod. 2013 Mar 7;88(3):54. doi: 10.1095/biolreprod.112.104778. Print 2013 Mar.

PMID:
23303682
12.

Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.

Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE.

Cancer Res. 2010 Nov 15;70(22):9185-96. doi: 10.1158/0008-5472.CAN-10-1545. Epub 2010 Nov 2.

13.

Knockdown of CABYR-a/b increases chemosensitivity of human non-small cell lung cancer cells through inactivation of Akt.

Qian Z, Li M, Wang R, Xiao Q, Wang J, Li M, He D, Xiao X.

Mol Cancer Res. 2014 Mar;12(3):335-47. doi: 10.1158/1541-7786.MCR-13-0391. Epub 2013 Dec 20.

14.

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.

Science. 2005 Oct 14;310(5746):306-10.

15.

Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.

Watson KL, Moorehead RA.

BMC Cancer. 2013 Aug 7;13:375. doi: 10.1186/1471-2407-13-375.

16.

Enoxaparin sensitizes human non-small-cell lung carcinomas to gefitinib by inhibiting DOCK1 expression, vimentin phosphorylation, and Akt activation.

Pan Y, Li X, Duan J, Yuan L, Fan S, Fan J, Xiaokaiti Y, Yang H, Wang Y, Li X.

Mol Pharmacol. 2015;87(3):378-90. doi: 10.1124/mol.114.094425. Epub 2014 Dec 8.

PMID:
25488183
17.

Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.

Oqani RK, Lin T, Lee JE, Kang JW, Shin HY, Il Jin D.

Sci Rep. 2019 Mar 7;9(1):3831. doi: 10.1038/s41598-019-40358-3.

18.

An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis.

Suyama K, Yao J, Liang H, Benard O, Loudig OD, Amgalan D, McKimpson WM, Phillips GR, Segall J, Wang Y, Fineberg S, Norton L, Kitsis RN, Hazan RB.

Cancer Res. 2018 Jan 1;78(1):103-114. doi: 10.1158/0008-5472.CAN-15-1462. Epub 2017 Oct 16.

19.

Perifosine-mediated Akt inhibition in neuroendocrine tumor cells: role of specific Akt isoforms.

Zitzmann K, Vlotides G, Brand S, Lahm H, Spöttl G, Göke B, Auernhammer CJ.

Endocr Relat Cancer. 2012 May 24;19(3):423-34. doi: 10.1530/ERC-12-0074. Print 2012 Jun.

PMID:
22499437
20.

Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes.

Bryant MR, Marta CB, Kim FS, Bansal R.

Glia. 2009 Jul;57(9):935-46. doi: 10.1002/glia.20818.

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