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Control of transcriptional elongation.

Kwak H, Lis JT.

Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11. Review.


Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex.

Missra A, Gilmour DS.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11301-6. doi: 10.1073/pnas.1000681107. Epub 2010 Jun 4.


Structure of paused transcription complex Pol II-DSIF-NELF.

Vos SM, Farnung L, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):601-606. doi: 10.1038/s41586-018-0442-2. Epub 2018 Aug 22.


Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.

Vos SM, Farnung L, Boehning M, Wigge C, Linden A, Urlaub H, Cramer P.

Nature. 2018 Aug;560(7720):607-612. doi: 10.1038/s41586-018-0440-4. Epub 2018 Aug 22.


Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing.

Qiu Y, Gilmour DS.

J Biol Chem. 2017 Mar 31;292(13):5555-5570. doi: 10.1074/jbc.M116.760751. Epub 2017 Feb 17.


NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila.

Wu CH, Yamaguchi Y, Benjamin LR, Horvat-Gordon M, Washinsky J, Enerly E, Larsson J, Lambertsson A, Handa H, Gilmour D.

Genes Dev. 2003 Jun 1;17(11):1402-14.


Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes.

Egloff S, Al-Rawaf H, O'Reilly D, Murphy S.

Mol Cell Biol. 2009 Jul;29(14):4002-13. doi: 10.1128/MCB.00189-09. Epub 2009 May 18.


FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H.

Mol Cell. 2000 Jun;5(6):1067-72.


Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond.

Yamaguchi Y, Shibata H, Handa H.

Biochim Biophys Acta. 2013 Jan;1829(1):98-104. doi: 10.1016/j.bbagrm.2012.11.007. Epub 2012 Nov 29. Review.


BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes.

Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K.

Mol Cell Biol. 2013 Jun;33(12):2497-507. doi: 10.1128/MCB.01180-12. Epub 2013 Apr 15.


Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.

Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, Rao M, Yang H, Zhou K, Wang Y, Chen Y, Chen M, Zhuang S, Chen LF, Liu R, Chen R.

Nucleic Acids Res. 2016 Aug 19;44(14):6853-67. doi: 10.1093/nar/gkw571. Epub 2016 Jun 28.


Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing.

Li J, Liu Y, Rhee HS, Ghosh SK, Bai L, Pugh BF, Gilmour DS.

Mol Cell. 2013 Jun 6;50(5):711-22. doi: 10.1016/j.molcel.2013.05.016.


Getting up to speed with transcription elongation by RNA polymerase II.

Jonkers I, Lis JT.

Nat Rev Mol Cell Biol. 2015 Mar;16(3):167-77. doi: 10.1038/nrm3953. Epub 2015 Feb 18. Review.


RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.

Yu M, Yang W, Ni T, Tang Z, Nakadai T, Zhu J, Roeder RG.

Science. 2015 Dec 11;350(6266):1383-6. doi: 10.1126/science.aad2338.


Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.

Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP.

Nat Struct Mol Biol. 2012 Nov;19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14.


NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.

Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H.

Cell. 1999 Apr 2;97(1):41-51.


NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila.

Lee C, Li X, Hechmer A, Eisen M, Biggin MD, Venters BJ, Jiang C, Li J, Pugh BF, Gilmour DS.

Mol Cell Biol. 2008 May;28(10):3290-300. doi: 10.1128/MCB.02224-07. Epub 2008 Mar 10.


Promoter-proximal pausing of RNA polymerase II: an opportunity to regulate gene transcription.

Fujita T, Schlegel W.

J Recept Signal Transduct Res. 2010 Feb;30(1):31-42. doi: 10.3109/10799890903517921.


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