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P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation.

Hung SC, Choi CH, Said-Sadier N, Johnson L, Atanasova KR, Sellami H, Yilmaz Ö, Ojcius DM.

PLoS One. 2013 Jul 25;8(7):e70210. doi: 10.1371/journal.pone.0070210. Print 2013.


ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis.

Yilmaz O, Sater AA, Yao L, Koutouzis T, Pettengill M, Ojcius DM.

Cell Microbiol. 2010 Feb;12(2):188-98. doi: 10.1111/j.1462-5822.2009.01390.x. Epub 2009 Oct 6.


Mechanisms that lead to the regulation of NLRP3 inflammasome expression and activation in human dental pulp fibroblasts.

Zhang A, Wang P, Ma X, Yin X, Li J, Wang H, Jiang W, Jia Q, Ni L.

Mol Immunol. 2015 Aug;66(2):253-62. doi: 10.1016/j.molimm.2015.03.009. Epub 2015 Apr 2.


The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.

Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA.

Brain Pathol. 2012 May;22(3):295-306. doi: 10.1111/j.1750-3639.2011.00531.x. Epub 2011 Oct 27.


The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1β production and activates the NLRP3 inflammasome in human macrophages.

Huang TT, Ojcius DM, Young JD, Wu YH, Ko YF, Wong TY, Wu CY, Lu CC, Lai HC.

PLoS One. 2012;7(7):e41383. doi: 10.1371/journal.pone.0041383. Epub 2012 Jul 23.


Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7.

Hussen J, Düvel A, Koy M, Schuberth HJ.

Dev Comp Immunol. 2012 Oct;38(2):312-20. doi: 10.1016/j.dci.2012.06.004. Epub 2012 Jun 19.


ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy.

Chen K, Zhang J, Zhang W, Zhang J, Yang J, Li K, He Y.

Int J Biochem Cell Biol. 2013 May;45(5):932-43. doi: 10.1016/j.biocel.2013.02.009. Epub 2013 Feb 19.


Activation of NLRP3 and AIM2 inflammasomes by Porphyromonas gingivalis infection.

Park E, Na HS, Song YR, Shin SY, Kim YM, Chung J.

Infect Immun. 2014 Jan;82(1):112-23. doi: 10.1128/IAI.00862-13. Epub 2013 Oct 14.


TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

He Y, Franchi L, Núñez G.

J Immunol. 2013 Jan 1;190(1):334-9. doi: 10.4049/jimmunol.1202737. Epub 2012 Dec 7.


Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.


Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation.

Qu Y, Misaghi S, Newton K, Gilmour LL, Louie S, Cupp JE, Dubyak GR, Hackos D, Dixit VM.

J Immunol. 2011 Jun 1;186(11):6553-61. doi: 10.4049/jimmunol.1100478. Epub 2011 Apr 20.


Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death.

Draganov D, Gopalakrishna-Pillai S, Chen YR, Zuckerman N, Moeller S, Wang C, Ann D, Lee PP.

Sci Rep. 2015 Nov 10;5:16222. doi: 10.1038/srep16222.


Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway.

Kankkunen P, Välimäki E, Rintahaka J, Palomäki J, Nyman T, Alenius H, Wolff H, Matikainen S.

Hum Immunol. 2014 Feb;75(2):134-40. doi: 10.1016/j.humimm.2013.11.010. Epub 2013 Nov 20.


Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway.

Niemi K, Teirilä L, Lappalainen J, Rajamäki K, Baumann MH, Öörni K, Wolff H, Kovanen PT, Matikainen S, Eklund KK.

J Immunol. 2011 Jun 1;186(11):6119-28. doi: 10.4049/jimmunol.1002843. Epub 2011 Apr 20.


Differential role of pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes.

Parzych K, Zetterqvist AV, Wright WR, Kirkby NS, Mitchell JA, Paul-Clark MJ.

FASEB J. 2017 Jun;31(6):2439-2445. doi: 10.1096/fj.201600256. Epub 2017 Feb 28.


P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3/IL-1β pathway.

Yin J, Wang Y, Hu H, Li X, Xue M, Cheng W, Wang Y, Li X, Yang N, Shi Y, Yan S.

J Cell Mol Med. 2017 Nov;21(11):2695-2710. doi: 10.1111/jcmm.13185. Epub 2017 May 4.


Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.

Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Gröne HJ, Schaefer L.

J Biol Chem. 2009 Sep 4;284(36):24035-48. doi: 10.1074/jbc.M109.014266. Epub 2009 Jul 15.


Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.

Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J.

PLoS One. 2012;7(4):e35812. doi: 10.1371/journal.pone.0035812. Epub 2012 Apr 25.


The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.

Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.

Cell Death Dis. 2015 Feb 5;6:e1629. doi: 10.1038/cddis.2014.576.


Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species.

Oh JY, Ko JH, Lee HJ, Yu JM, Choi H, Kim MK, Wee WR, Prockop DJ.

Stem Cells. 2014 Jun;32(6):1553-63. doi: 10.1002/stem.1608.

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