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The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.

Ho AW, Garg AV, Monin L, Simpson-Abelson MR, Kinner L, Gaffen SL.

PLoS One. 2013 Jul 29;8(7):e70168. doi: 10.1371/journal.pone.0070168. Print 2013.


IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail.

Ho AW, Shen F, Conti HR, Patel N, Childs EE, Peterson AC, Hernández-Santos N, Kolls JK, Kane LP, Ouyang W, Gaffen SL.

J Immunol. 2010 Jul 15;185(2):1063-70. doi: 10.4049/jimmunol.0903739. Epub 2010 Jun 16.


A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals.

da Silva CG, Studer P, Skroch M, Mahiou J, Minussi DC, Peterson CR, Wilson SW, Patel VI, Ma A, Csizmadia E, Ferran C.

Hepatology. 2013 May;57(5):2014-25. doi: 10.1002/hep.26197. Epub 2013 Apr 5.


ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW.

J Biol Chem. 2011 Oct 21;286(42):36592-602. doi: 10.1074/jbc.M111.283762. Epub 2011 Sep 1.


TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM.

Curr Biol. 2003 Sep 2;13(17):1459-68.


IL-17RC is critically required to maintain baseline A20 production to repress JNK isoform-dependent tumor-specific proliferation.

Yan C, Lei Y, Lin TJ, Hoskin DW, Ma A, Wang J.

Oncotarget. 2017 Jun 27;8(26):43153-43168. doi: 10.18632/oncotarget.17820.


The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.

Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM.

J Immunol. 2008 Aug 15;181(4):2799-805.


An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling.

Krstic J, Obradovic H, Kukolj T, Mojsilovic S, Okic-Dordevic I, Bugarski D, Santibanez JF.

Protein Pept Lett. 2015;22(7):570-8. Review.


The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW.

Nat Immunol. 2011 Jul 17;12(9):834-43. doi: 10.1038/ni.2066.


The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW.

EMBO J. 2009 Mar 4;28(5):513-22. doi: 10.1038/emboj.2008.285. Epub 2009 Jan 8.


Interleukin-17 (IL-17)-induced microRNA 873 (miR-873) contributes to the pathogenesis of experimental autoimmune encephalomyelitis by targeting A20 ubiquitin-editing enzyme.

Liu X, He F, Pang R, Zhao D, Qiu W, Shan K, Zhang J, Lu Y, Li Y, Wang Y.

J Biol Chem. 2014 Oct 17;289(42):28971-86. doi: 10.1074/jbc.M114.577429. Epub 2014 Sep 2.


The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling.

Garg AV, Ahmed M, Vallejo AN, Ma A, Gaffen SL.

Sci Signal. 2013 Jun 4;6(278):ra44. doi: 10.1126/scisignal.2003699.


Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved α-helix for Act1 binding and IL-17 signaling.

Zhang B, Liu C, Qian W, Han Y, Li X, Deng J.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1476-83. doi: 10.1107/S1399004714005227. Epub 2014 Apr 30.


Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.

Shembade N, Ma A, Harhaj EW.

Science. 2010 Feb 26;327(5969):1135-9. doi: 10.1126/science.1182364.


Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.

Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ, Levey AI, Betarbet RS.

Neurosci Lett. 2012 Jun 27;520(1):104-9. doi: 10.1016/j.neulet.2012.05.043. Epub 2012 May 23.


Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20.

Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang J, Xu T, Cao X.

Immunity. 2013 Sep 19;39(3):470-81. doi: 10.1016/j.immuni.2013.08.016. Epub 2013 Sep 5.


SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction.

Onishi RM, Park SJ, Hanel W, Ho AW, Maitra A, Gaffen SL.

J Biol Chem. 2010 Oct 22;285(43):32751-9. doi: 10.1074/jbc.M110.121418. Epub 2010 Aug 20.


Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A.

Immunity. 2013 May 23;38(5):896-905. doi: 10.1016/j.immuni.2013.03.008. Epub 2013 Apr 18.


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