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Items: 1 to 20 of 181

1.

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT.

Mol Cell. 2013 Aug 8;51(3):283-96. doi: 10.1016/j.molcel.2013.06.020. Epub 2013 Aug 1.

2.

Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Linares JF, Duran A, Reina-Campos M, Aza-Blanc P, Campos A, Moscat J, Diaz-Meco MT.

Cell Rep. 2015 Aug 25;12(8):1339-52. doi: 10.1016/j.celrep.2015.07.045. Epub 2015 Aug 13.

3.

p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Duran A, Amanchy R, Linares JF, Joshi J, Abu-Baker S, Porollo A, Hansen M, Moscat J, Diaz-Meco MT.

Mol Cell. 2011 Oct 7;44(1):134-46. doi: 10.1016/j.molcel.2011.06.038.

4.

The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.

Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, Moscat J.

J Biol Chem. 2005 Oct 21;280(42):35625-9. Epub 2005 Aug 3.

5.

TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1.

Zotti T, Scudiero I, Settembre P, Ferravante A, Mazzone P, D'Andrea L, Reale C, Vito P, Stilo R.

Mol Immunol. 2014 Mar;58(1):27-31. doi: 10.1016/j.molimm.2013.10.015. Epub 2013 Nov 20.

6.

p62 regulates CD40-mediated NFκB activation in macrophages through interaction with TRAF6.

Seibold K, Ehrenschwender M.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):330-5. doi: 10.1016/j.bbrc.2015.06.153. Epub 2015 Jun 29.

PMID:
26133577
8.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Katsuragi Y, Ichimura Y, Komatsu M.

FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16. Review.

9.

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

Stretton C, Hoffmann TM, Munson MJ, Prescott A, Taylor PM, Ganley IG, Hundal HS.

Biochem J. 2015 Sep 1;470(2):207-21. doi: 10.1042/BJ20150404. Epub 2015 Jul 9.

10.

Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway.

Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O.

Int J Oncol. 2013 Aug;43(2):447-56. doi: 10.3892/ijo.2013.1984. Epub 2013 Jun 12.

PMID:
23759924
11.

The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.

Deng L, Jiang C, Chen L, Jin J, Wei J, Zhao L, Chen M, Pan W, Xu Y, Chu H, Wang X, Ge X, Li D, Liao L, Liu M, Li L, Wang P.

Mol Cell. 2015 Jun 4;58(5):804-18. doi: 10.1016/j.molcel.2015.03.033. Epub 2015 Apr 30.

12.

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.

Schweitzer LD, Comb WC, Bar-Peled L, Sabatini DM.

Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.

13.

PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation.

Nakamura K, Kimple AJ, Siderovski DP, Johnson GL.

J Biol Chem. 2010 Jan 15;285(3):2077-89. doi: 10.1074/jbc.M109.065102. Epub 2009 Nov 10.

14.

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.

Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, Wei W.

Nature. 2017 May 18;545(7654):365-369. doi: 10.1038/nature22344. Epub 2017 May 10.

15.

p62: a versatile multitasker takes on cancer.

Moscat J, Diaz-Meco MT.

Trends Biochem Sci. 2012 Jun;37(6):230-6. doi: 10.1016/j.tibs.2012.02.008. Epub 2012 Mar 15. Review.

16.

Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62/sequestosome 1.

Huang S, Yang ZJ, Yu C, Sinicrope FA.

J Biol Chem. 2011 Nov 18;286(46):40002-12. doi: 10.1074/jbc.M111.297432. Epub 2011 Sep 23.

17.

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.

Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5.

19.

Absence of lipofuscin in motor neurons of SOD1-linked ALS mice.

Bandyopadhyay U, Nagy M, Fenton WA, Horwich AL.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11055-60. doi: 10.1073/pnas.1409314111. Epub 2014 Jul 14.

20.

TRAF6 and p62 inhibit amyloid β-induced neuronal death through p75 neurotrophin receptor.

Geetha T, Zheng C, McGregor WC, Douglas White B, Diaz-Meco MT, Moscat J, Babu JR.

Neurochem Int. 2012 Dec;61(8):1289-93. doi: 10.1016/j.neuint.2012.09.005. Epub 2012 Sep 24.

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