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Items: 1 to 20 of 102

1.

Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors.

Bum-Erdene K, Gagarinov IA, Collins PM, Winger M, Pearson AG, Wilson JC, Leffler H, Nilsson UJ, Grice ID, Blanchard H.

Chembiochem. 2013 Jul 22;14(11):1331-42. doi: 10.1002/cbic.201300245.

PMID:
23864426
2.

Taloside inhibitors of galectin-1 and galectin-3.

Collins PM, Oberg CT, Leffler H, Nilsson UJ, Blanchard H.

Chem Biol Drug Des. 2012 Mar;79(3):339-46. doi: 10.1111/j.1747-0285.2011.01283.x. Epub 2012 Jan 11.

PMID:
22136701
3.

Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.

Stannard KA, Collins PM, Ito K, Sullivan EM, Scott SA, Gabutero E, Darren Grice I, Low P, Nilsson UJ, Leffler H, Blanchard H, Ralph SJ.

Cancer Lett. 2010 Dec 28;299(2):95-110. doi: 10.1016/j.canlet.2010.08.005. Epub 2010 Sep 9.

PMID:
20826047
4.

1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors.

Salameh BA, Cumpstey I, Sundin A, Leffler H, Nilsson UJ.

Bioorg Med Chem. 2010 Jul 15;18(14):5367-78. doi: 10.1016/j.bmc.2010.05.040. Epub 2010 May 20.

PMID:
20538469
5.

Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors.

Zhang H, Laaf D, Elling L, Pieters RJ.

Bioconjug Chem. 2018 Apr 18;29(4):1266-1275. doi: 10.1021/acs.bioconjchem.8b00047. Epub 2018 Mar 7.

6.

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ.

J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11.

7.

Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3.

van Scherpenzeel M, Moret EE, Ballell L, Liskamp RM, Nilsson UJ, Leffler H, Pieters RJ.

Chembiochem. 2009 Jul 6;10(10):1724-33. doi: 10.1002/cbic.200900198.

PMID:
19492387
8.

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.

Rajput VK, MacKinnon A, Mandal S, Collins P, Blanchard H, Leffler H, Sethi T, Schambye H, Mukhopadhyay B, Nilsson UJ.

J Med Chem. 2016 Sep 8;59(17):8141-7. doi: 10.1021/acs.jmedchem.6b00957. Epub 2016 Aug 23.

PMID:
27500311
9.
10.

Binding free energy calculations of galectin-3-ligand interactions.

Mandal TK, Mukhopadhyay C.

Protein Eng. 2002 Dec;15(12):979-86.

PMID:
12601137
12.

A first QSAR model for galectin-3 glycomimetic inhibitors based on 3D docked structures.

Sirois S, Giguère D, Roy R.

Med Chem. 2006 Sep;2(5):481-9.

PMID:
17017987
13.

The water network in galectin-3 ligand binding site guides inhibitor design.

Su J, Zhang T, Wang P, Liu F, Tai G, Zhou Y.

Acta Biochim Biophys Sin (Shanghai). 2015 Mar;47(3):192-8. doi: 10.1093/abbs/gmu132. Epub 2015 Feb 5.

PMID:
25662390
14.

C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions.

Cumpstey I, Sundin A, Leffler H, Nilsson UJ.

Angew Chem Int Ed Engl. 2005 Aug 12;44(32):5110-2. No abstract available.

PMID:
16007713
15.

NMR and MD investigations of human galectin-1/oligosaccharide complexes.

Meynier C, Feracci M, Espeli M, Chaspoul F, Gallice P, Schiff C, Guerlesquin F, Roche P.

Biophys J. 2009 Dec 16;97(12):3168-77. doi: 10.1016/j.bpj.2009.09.026.

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19.

Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.

van Hattum H, Branderhorst HM, Moret EE, Nilsson UJ, Leffler H, Pieters RJ.

J Med Chem. 2013 Feb 14;56(3):1350-4. doi: 10.1021/jm301677r. Epub 2013 Jan 23.

PMID:
23281927
20.

Disaccharide binding to galectin-1: free energy calculations and molecular recognition mechanism.

Echeverria I, Amzel LM.

Biophys J. 2011 May 4;100(9):2283-92. doi: 10.1016/j.bpj.2011.03.032.

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