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Items: 1 to 20 of 341

1.

Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism.

Stout GJ, Stigter EC, Essers PB, Mulder KW, Kolkman A, Snijders DS, van den Broek NJ, Betist MC, Korswagen HC, Macinnes AW, Brenkman AB.

Mol Syst Biol. 2013 Jul 2;9:679. doi: 10.1038/msb.2013.35.

2.

Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.

Depuydt G, Xie F, Petyuk VA, Shanmugam N, Smolders A, Dhondt I, Brewer HM, Camp DG 2nd, Smith RD, Braeckman BP.

Mol Cell Proteomics. 2013 Dec;12(12):3624-39. doi: 10.1074/mcp.M113.027383. Epub 2013 Sep 3.

3.

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.

Lin K, Hsin H, Libina N, Kenyon C.

Nat Genet. 2001 Jun;28(2):139-45.

PMID:
11381260
4.

pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.

Monje JM, Brokate-Llanos AM, Pérez-Jiménez MM, Fidalgo MA, Muñoz MJ.

Aging Cell. 2011 Dec;10(6):1021-31. doi: 10.1111/j.1474-9726.2011.00747.x.

5.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.

6.

14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.

Araiz C, Château MT, Galas S.

Exp Gerontol. 2008 Jun;43(6):505-19. doi: 10.1016/j.exger.2008.03.001. Epub 2008 Mar 18.

7.

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.

Seo M, Seo K, Hwang W, Koo HJ, Hahm JH, Yang JS, Han SK, Hwang D, Kim S, Jang SK, Lee Y, Nam HG, Lee SJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4246-55. doi: 10.1073/pnas.1505451112. Epub 2015 Jul 20.

8.

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.

Libina N, Berman JR, Kenyon C.

Cell. 2003 Nov 14;115(4):489-502.

9.

Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.

Simon M, Sarkies P, Ikegami K, Doebley AL, Goldstein LD, Mitchell J, Sakaguchi A, Miska EA, Ahmed S.

Cell Rep. 2014 May 8;7(3):762-73. doi: 10.1016/j.celrep.2014.03.056. Epub 2014 Apr 24.

10.

LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.

Depuydt G, Xie F, Petyuk VA, Smolders A, Brewer HM, Camp DG 2nd, Smith RD, Braeckman BP.

J Proteome Res. 2014 Apr 4;13(4):1938-56. doi: 10.1021/pr401081b. Epub 2014 Mar 3.

11.

Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.

Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ, Zimniak P.

Aging Cell. 2005 Dec;4(6):299-307.

12.

The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans.

Mack HID, Zhang P, Fonslow BR, Yates JR.

Aging (Albany NY). 2017 May 25;9(5):1414-1432. doi: 10.18632/aging.101244.

13.

Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.

Chen D, Li PW, Goldstein BA, Cai W, Thomas EL, Chen F, Hubbard AE, Melov S, Kapahi P.

Cell Rep. 2013 Dec 26;5(6):1600-10. doi: 10.1016/j.celrep.2013.11.018. Epub 2013 Dec 12.

14.

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.

Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G.

Nature. 1997 Oct 30;389(6654):994-9.

PMID:
9353126
15.

Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.

Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, Hu PJ.

Dev Biol. 2008 Mar 15;315(2):290-302. doi: 10.1016/j.ydbio.2007.12.032. Epub 2008 Jan 3.

16.

TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.

Ferguson AA, Roy S, Kormanik KN, Kim Y, Dumas KJ, Ritov VB, Matern D, Hu PJ, Fisher AL.

PLoS Genet. 2013;9(12):e1004020. doi: 10.1371/journal.pgen.1004020. Epub 2013 Dec 19.

17.

C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.

Honnen SJ, Büchter C, Schröder V, Hoffmann M, Kohara Y, Kampkötter A, Bossinger O.

PLoS One. 2012;7(2):e32183. doi: 10.1371/journal.pone.0032183. Epub 2012 Feb 16.

19.
20.

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans.

Son HG, Seo M, Ham S, Hwang W, Lee D, An SW, Artan M, Seo K, Kaletsky R, Arey RN, Ryu Y, Ha CM, Kim YK, Murphy CT, Roh TY, Nam HG, Lee SV.

Nat Commun. 2017 Mar 9;8:14749. doi: 10.1038/ncomms14749.

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