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Items: 1 to 20 of 138

1.

Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion.

Jensen MV, Haldeman JM, Zhang H, Lu D, Huising MO, Vale WW, Hohmeier HE, Rosenberg P, Newgard CB.

J Biol Chem. 2013 Aug 9;288(32):23128-40. doi: 10.1074/jbc.M113.491654. Epub 2013 Jun 20.

2.

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.

Li XN, Herrington J, Petrov A, Ge L, Eiermann G, Xiong Y, Jensen MV, Hohmeier HE, Newgard CB, Garcia ML, Wagner M, Zhang BB, Thornberry NA, Howard AD, Kaczorowski GJ, Zhou YP.

J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. doi: 10.1124/jpet.112.199083. Epub 2012 Nov 16.

PMID:
23161216
3.

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV.

J Biol Chem. 2006 Oct 13;281(41):30593-602. Epub 2006 Aug 15.

4.

The dicarboxylate carrier plays a role in mitochondrial malate transport and in the regulation of glucose-stimulated insulin secretion from rat pancreatic beta cells.

Huypens P, Pillai R, Sheinin T, Schaefer S, Huang M, Odegaard ML, Ronnebaum SM, Wettig SD, Joseph JW.

Diabetologia. 2011 Jan;54(1):135-45. doi: 10.1007/s00125-010-1923-5. Epub 2010 Oct 15.

PMID:
20949348
5.

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Wang J, Saleh MC, Chan CB, Tsushima RG, Salapatek AM, Wheeler MB.

J Biol Chem. 2002 Nov 22;277(47):44938-45. Epub 2002 Sep 20.

6.

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion.

Patterson JN, Cousteils K, Lou JW, Manning Fox JE, MacDonald PE, Joseph JW.

J Biol Chem. 2014 May 9;289(19):13335-46. doi: 10.1074/jbc.M113.521666. Epub 2014 Mar 27.

7.

SNAP-25(1-180) enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet beta-cells.

Zhuang GQ, Wu W, Liu F, Ma JL, Luo YX, Xiao ZX, Liu Y, Wang W, He Y.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):812-6. doi: 10.1016/j.bbrc.2008.12.059. Epub 2008 Dec 25.

PMID:
19103161
8.

Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.

MacDonald PE, Ha XF, Wang J, Smukler SR, Sun AM, Gaisano HY, Salapatek AM, Backx PH, Wheeler MB.

Mol Endocrinol. 2001 Aug;15(8):1423-35.

PMID:
11463864
9.

Voltage-dependent metabolic regulation of Kv2.1 channels in pancreatic beta-cells.

Yoshida M, Nakata M, Yamato S, Dezaki K, Sugawara H, Ishikawa SE, Kawakami M, Yada T, Kakei M.

Biochem Biophys Res Commun. 2010 May 28;396(2):304-9. doi: 10.1016/j.bbrc.2010.04.088. Epub 2010 Apr 18.

PMID:
20403337
10.

Metabolic cycling in control of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1287-97. doi: 10.1152/ajpendo.90604.2008. Epub 2008 Aug 26. Review.

11.

A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.

Guay C, Joly E, Pepin E, Barbeau A, Hentsch L, Pineda M, Madiraju SR, Brunengraber H, Prentki M.

PLoS One. 2013 Oct 10;8(10):e77097. doi: 10.1371/journal.pone.0077097. eCollection 2013.

12.

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE.

Diabetologia. 2012 Jun;55(6):1709-20. doi: 10.1007/s00125-012-2512-6. Epub 2012 Mar 13.

PMID:
22411134
13.

Partial blockade of Kv2.1 channel potentiates GLP-1's insulinotropic effects in islets and reduces its dose required for improving glucose tolerance in type 2 diabetic male mice.

Sukma Rita R, Dezaki K, Kurashina T, Kakei M, Yada T.

Endocrinology. 2015 Jan;156(1):114-23. doi: 10.1210/en.2014-1728.

PMID:
25337656
14.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

15.

The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons.

Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert PP.

Physiol Rep. 2016 Mar;4(6). pii: e12731. doi: 10.14814/phy2.12731. Epub 2016 Mar 31.

16.

Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.

Archer SL, Wu XC, Thébaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED.

Circ Res. 2004 Aug 6;95(3):308-18. Epub 2004 Jun 24.

PMID:
15217912
17.

Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

Jacobson DA, Kuznetsov A, Lopez JP, Kash S, Ammälä CE, Philipson LH.

Cell Metab. 2007 Sep;6(3):229-35.

18.

SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways.

Zhou TT, Quan LL, Chen LP, Du T, Sun KX, Zhang JC, Yu L, Li Y, Wan P, Chen LL, Jiang BH, Hu LH, Chen J, Shen X.

Cell Death Dis. 2016 May 5;7:e2216. doi: 10.1038/cddis.2016.119.

19.

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion.

Guay C, Madiraju SR, Aumais A, Joly E, Prentki M.

J Biol Chem. 2007 Dec 7;282(49):35657-65. Epub 2007 Oct 10.

20.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE.

Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12.

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