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Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity.

Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL.

Dis Model Mech. 2013 Sep;6(5):1133-45. doi: 10.1242/dmm.011916. Epub 2013 May 2.


Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.

Pelling M, Anthwal N, McNay D, Gradwohl G, Leiter AB, Guillemot F, Ang SL.

Dev Biol. 2011 Jan 15;349(2):406-16. doi: 10.1016/j.ydbio.2010.11.007. Epub 2010 Nov 11.


ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice.

Huang H, Lee SH, Ye C, Lima IS, Oh BC, Lowell BB, Zabolotny JM, Kim YB.

Endocrinology. 2013 Oct;154(10):3660-70. doi: 10.1210/en.2013-1343. Epub 2013 Jul 24.


IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.

Nakata M, Yamamoto S, Okada T, Gantulga D, Okano H, Ozawa K, Yada T.

Int J Obes (Lond). 2016 Mar;40(3):425-33. doi: 10.1038/ijo.2015.201. Epub 2015 Oct 5.


Leptin Resistance Contributes to Obesity in Mice with Null Mutation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 1.

Heinrich G, Russo L, Castaneda TR, Pfeiffer V, Ghadieh HE, Ghanem SS, Wu J, Faulkner LD, Ergün S, McInerney MF, Hill JW, Najjar SM.

J Biol Chem. 2016 May 20;291(21):11124-32. doi: 10.1074/jbc.M116.716431. Epub 2016 Mar 21.


Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.

Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D.

PLoS Biol. 2011 Jul;9(7):e1001112. doi: 10.1371/journal.pbio.1001112. Epub 2011 Jul 26. Erratum in: PLoS Biol. 2016 Mar;14(3):e1002428.


Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice.

Mercer RE, Michaelson SD, Chee MJ, Atallah TA, Wevrick R, Colmers WF.

PLoS Genet. 2013;9(1):e1003207. doi: 10.1371/journal.pgen.1003207. Epub 2013 Jan 17.


Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the Magel2-null mouse model of Prader-Willi syndrome.

Pravdivyi I, Ballanyi K, Colmers WF, Wevrick R.

Hum Mol Genet. 2015 Aug 1;24(15):4276-83. doi: 10.1093/hmg/ddv159. Epub 2015 Apr 29.


Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability.

Vella KR, Burnside AS, Brennan KM, Good DJ.

J Neuroendocrinol. 2007 Jul;19(7):499-510.


Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.

Xi D, Gandhi N, Lai M, Kublaoui BM.

PLoS One. 2012;7(4):e36453. doi: 10.1371/journal.pone.0036453. Epub 2012 Apr 27.


Expression of neuropeptide Y and agouti-related peptide in the hypothalamic arcuate nucleus of newborn neurogenin3 null mutant mice.

Arai Y, Gradwohl G, Kameda Y.

Cell Tissue Res. 2010 Apr;340(1):137-45. doi: 10.1007/s00441-009-0925-4. Epub 2010 Feb 3.


Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling.

Calvino C, Império GE, Wilieman M, Costa-E-Sousa RH, Souza LL, Trevenzoli IH, Pazos-Moura CC.

Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.


Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity.

Malhotra R, Warne JP, Salas E, Xu AW, Debnath J.

Autophagy. 2015;11(1):145-54. doi: 10.1080/15548627.2014.998917.


Role of hypothalamic proopiomelanocortin neuron autophagy in the control of appetite and leptin response.

Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS.

Endocrinology. 2012 Apr;153(4):1817-26. doi: 10.1210/en.2011-1882. Epub 2012 Feb 14.


Hypothalamic CART and serum leptin levels are reduced in the anorectic (anx/anx) mouse.

Johansen JE, Broberger C, Lavebratt C, Johansson C, Kuhar MJ, Hökfelt T, Schalling M.

Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):97-105.


Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.

Nasif S, de Souza FS, González LE, Yamashita M, Orquera DP, Low MJ, Rubinstein M.

Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1861-70. doi: 10.1073/pnas.1500672112. Epub 2015 Mar 30.


VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting.

Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR.

J Neurosci. 2002 Aug 15;22(16):6929-38.


Hypothalamic bHLH transcription factors are novel candidates in the regulation of energy balance.

Nilaweera KN, Ellis C, Barrett P, Mercer JG, Morgan PJ.

Eur J Neurosci. 2002 Feb;15(4):644-50.


Inducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity.

Tolson KP, Gemelli T, Meyer D, Yazdani U, Kozlitina J, Zinn AR.

Endocrinology. 2014 Jul;155(7):2436-44. doi: 10.1210/en.2013-2125. Epub 2014 Apr 28.

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