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Antagonism of the protein kinase R pathway by the guinea pig cytomegalovirus US22-family gene gp145.

Bierle CJ, Schleiss MR, Geballe AP.

Virology. 2012 Nov 10;433(1):157-66. doi: 10.1016/j.virol.2012.08.005. Epub 2012 Aug 20.


Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143.

Budt M, Niederstadt L, Valchanova RS, Jonjić S, Brune W.

J Virol. 2009 Feb;83(3):1260-70. doi: 10.1128/JVI.01558-08. Epub 2008 Nov 19.


Variola virus E3L Zα domain, but not its Z-DNA binding activity, is required for PKR inhibition.

Thakur M, Seo EJ, Dever TE.

RNA. 2014 Feb;20(2):214-27. doi: 10.1261/rna.042341.113. Epub 2013 Dec 13.


Viral host-range factor C7 or K1 is essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit protein kinase R-mediated phosphorylation of eukaryotic translation initiation factor 2alpha.

Backes S, Sperling KM, Zwilling J, Gasteiger G, Ludwig H, Kremmer E, Schwantes A, Staib C, Sutter G.

J Gen Virol. 2010 Feb;91(Pt 2):470-82. doi: 10.1099/vir.0.015347-0. Epub 2009 Oct 21.


Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain.

Romano PR, Zhang F, Tan SL, Garcia-Barrio MT, Katze MG, Dever TE, Hinnebusch AG.

Mol Cell Biol. 1998 Dec;18(12):7304-16.


Double-stranded RNA binding by the human cytomegalovirus PKR antagonist TRS1.

Bierle CJ, Semmens KM, Geballe AP.

Virology. 2013 Jul 20;442(1):28-37. doi: 10.1016/j.virol.2013.03.024. Epub 2013 Apr 17.


Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.

He Y, Tan SL, Tareen SU, Vijaysri S, Langland JO, Jacobs BL, Katze MG.

J Virol. 2001 Jun;75(11):5090-8.


Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.

Zhang P, Langland JO, Jacobs BL, Samuel CE.

J Virol. 2009 Jun;83(11):5718-25. doi: 10.1128/JVI.00224-09. Epub 2009 Mar 25.


Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice.

Rice AD, Turner PC, Embury JE, Moldawer LL, Baker HV, Moyer RW.

J Virol. 2011 Jan;85(1):550-67. doi: 10.1128/JVI.00254-10. Epub 2010 Oct 13.


Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus.

Zhu R, Zhang YB, Zhang QY, Gui JF.

J Virol. 2008 Jul;82(14):6889-901. doi: 10.1128/JVI.02385-07. Epub 2008 Apr 30.


Formation of antiviral cytoplasmic granules during orthopoxvirus infection.

Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH.

J Virol. 2011 Feb;85(4):1581-93. doi: 10.1128/JVI.02247-10. Epub 2010 Dec 8.


Species specificity of protein kinase r antagonism by cytomegalovirus TRS1 genes.

Child SJ, Brennan G, Braggin JE, Geballe AP.

J Virol. 2012 Apr;86(7):3880-9. doi: 10.1128/JVI.06158-11. Epub 2012 Jan 25. Erratum in: J Virol. 2012 Nov;86(22):12470.


Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.

Wolferstätter M, Schweneker M, Späth M, Lukassen S, Klingenberg M, Brinkmann K, Wielert U, Lauterbach H, Hochrein H, Chaplin P, Suter M, Hausmann J.

J Virol. 2014 Dec;88(24):14396-411. doi: 10.1128/JVI.02082-14. Epub 2014 Oct 8.


Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.

Marshall EE, Bierle CJ, Brune W, Geballe AP.

J Virol. 2009 May;83(9):4112-20. doi: 10.1128/JVI.02489-08. Epub 2009 Feb 11.

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