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Items: 1 to 20 of 93


Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD.

Cell Stem Cell. 2012 Jul 6;11(1):23-35. doi: 10.1016/j.stem.2012.03.016.


An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation.

Potts MB, Lim DA.

Cell Stem Cell. 2012 Jul 6;11(1):5-6. doi: 10.1016/j.stem.2012.06.003.


Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.

Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J.

Stem Cell Reports. 2015 Dec 8;5(6):988-995. doi: 10.1016/j.stemcr.2015.10.014. Epub 2015 Nov 19.


The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner.

Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J.

Stem Cell Reports. 2016 Oct 11;7(4):719-734. doi: 10.1016/j.stemcr.2016.08.007. Epub 2016 Sep 8.


A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice.

Chatterjee S, Mizar P, Cassel R, Neidl R, Selvi BR, Mohankrishna DV, Vedamurthy BM, Schneider A, Bousiges O, Mathis C, Cassel JC, Eswaramoorthy M, Kundu TK, Boutillier AL.

J Neurosci. 2013 Jun 26;33(26):10698-712. doi: 10.1523/JNEUROSCI.5772-12.2013.


Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells.

Tischfield DJ, Kim J, Anderson SA.

Stem Cell Reports. 2017 May 9;8(5):1135-1143. doi: 10.1016/j.stemcr.2017.03.015. Epub 2017 Apr 13.


12-Deoxyphorbols Promote Adult Neurogenesis by Inducing Neural Progenitor Cell Proliferation via PKC Activation.

Geribaldi-Doldán N, Flores-Giubi E, Murillo-Carretero M, García-Bernal F, Carrasco M, Macías-Sánchez AJ, Domínguez-Riscart J, Verástegui C, Hernández-Galán R, Castro C.

Int J Neuropsychopharmacol. 2015 Jul 29;19(1). pii: pyv085. doi: 10.1093/ijnp/pyv085.


AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.

Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn R, Braun U, Leitges M, Farese RV.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E179-92. doi: 10.1152/ajpendo.00392.2009. Epub 2009 Nov 3.


Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

Pillat MM, Lameu C, Trujillo CA, Glaser T, Cappellari AR, Negraes PD, Battastini AM, Schwindt TT, Muotri AR, Ulrich H.

J Cell Sci. 2016 Sep 15;129(18):3437-48. doi: 10.1242/jcs.192534. Epub 2016 Aug 15.


PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice.

Park HR, Kim JY, Lee Y, Chun HJ, Choi YW, Shin HK, Choi BT, Kim CM, Lee J.

Neurosci Lett. 2016 Mar 23;617:254-63. doi: 10.1016/j.neulet.2016.02.036. Epub 2016 Feb 23.


Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis.

Park HR, Kong KH, Yu BP, Mattson MP, Lee J.

J Biol Chem. 2012 Dec 14;287(51):42588-600. doi: 10.1074/jbc.M112.406413. Epub 2012 Oct 26.


CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.

Wang J, Weaver IC, Gauthier-Fisher A, Wang H, He L, Yeomans J, Wondisford F, Kaplan DR, Miller FD.

Dev Cell. 2010 Jan 19;18(1):114-25. doi: 10.1016/j.devcel.2009.10.023.


Recombinant human thioredoxin-1 promotes neurogenesis and facilitates cognitive recovery following cerebral ischemia in mice.

Tian L, Nie H, Zhang Y, Chen Y, Peng Z, Cai M, Wei H, Qin P, Dong H, Xiong L.

Neuropharmacology. 2014 Feb;77:453-64. doi: 10.1016/j.neuropharm.2013.10.027. Epub 2013 Nov 7.


Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory.

Wang J, Song L, Zhang Q, Zhang W, An L, Zhang Y, Tong D, Zhao B, Chen S, Zhao S.

Toxicol Lett. 2015 Jan 5;232(1):263-70. doi: 10.1016/j.toxlet.2014.11.017. Epub 2014 Nov 18.


Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain.

Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA.

Exp Neurol. 2014 Jun;256:93-104. doi: 10.1016/j.expneurol.2014.04.001. Epub 2014 Apr 12.


High glucose suppresses embryonic stem cell differentiation into neural lineage cells.

Yang P, Shen WB, Reece EA, Chen X, Yang P.

Biochem Biophys Res Commun. 2016 Apr 1;472(2):306-12. doi: 10.1016/j.bbrc.2016.02.117. Epub 2016 Mar 3.


Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule.

Petrik D, Jiang Y, Birnbaum SG, Powell CM, Kim MS, Hsieh J, Eisch AJ.

FASEB J. 2012 Aug;26(8):3148-62. doi: 10.1096/fj.11-201426. Epub 2012 Apr 27.


Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury.

Dadwal P, Mahmud N, Sinai L, Azimi A, Fatt M, Wondisford FE, Miller FD, Morshead CM.

Stem Cell Reports. 2015 Aug 11;5(2):166-73. doi: 10.1016/j.stemcr.2015.06.011. Epub 2015 Jul 30.

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