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Items: 1 to 20 of 201

1.

Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.

Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM.

Neuroimage. 2012 Jan 2;59(1):193-201. doi: 10.1016/j.neuroimage.2011.07.034. Epub 2011 Jul 23.

2.

Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy.

Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM.

Cancer Res. 2010 Feb 15;70(4):1296-305. doi: 10.1158/0008-5472.CAN-09-2251. Epub 2010 Feb 9.

3.

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM.

Mol Cancer Ther. 2016 May;15(5):1113-22. doi: 10.1158/1535-7163.MCT-15-0769. Epub 2016 Feb 16.

4.

Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma.

Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM.

Neuro Oncol. 2012 Mar;14(3):315-25. doi: 10.1093/neuonc/nor209. Epub 2011 Dec 12.

5.

Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM.

Neuroimage Clin. 2016 Jun 23;12:180-9. doi: 10.1016/j.nicl.2016.06.018. eCollection 2016.

6.

HDAC inhibition in glioblastoma monitored by hyperpolarized 13 C MRSI.

Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM.

NMR Biomed. 2019 Feb;32(2):e4044. doi: 10.1002/nbm.4044. Epub 2018 Dec 18.

PMID:
30561869
7.

Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging.

Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ.

J Magn Reson Imaging. 2011 Jun;33(6):1284-90. doi: 10.1002/jmri.22563.

8.

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors.

Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ.

Neuro Oncol. 2010 Feb;12(2):133-44. doi: 10.1093/neuonc/nop043. Epub 2010 Jan 25.

9.

PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel.

Yang L, Clarke MJ, Carlson BL, Mladek AC, Schroeder MA, Decker P, Wu W, Kitange GJ, Grogan PT, Goble JM, Uhm J, Galanis E, Giannini C, Lane HA, James CD, Sarkaria JN.

Clin Cancer Res. 2008 Jun 15;14(12):3993-4001. doi: 10.1158/1078-0432.CCR-07-4152.

10.

Multimodal assessment of in vivo metabolism with hyperpolarized [1-13C]MR spectroscopy and 18F-FDG PET imaging in hepatocellular carcinoma tumor-bearing rats.

Menzel MI, Farrell EV, Janich MA, Khegai O, Wiesinger F, Nekolla S, Otto AM, Haase A, Schulte RF, Schwaiger M.

J Nucl Med. 2013 Jul;54(7):1113-9. doi: 10.2967/jnumed.112.110825. Epub 2013 Apr 17.

11.

Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.

Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6982-E6991. doi: 10.1073/pnas.1613345114. Epub 2017 Jul 31.

12.

Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.

Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO.

Cancer Res. 2014 Dec 1;74(23):7115-24. doi: 10.1158/0008-5472.CAN-14-0849. Epub 2014 Oct 15.

13.

Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging.

Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ.

Magn Reson Med. 2013 Jul;70(1):33-9. doi: 10.1002/mrm.24434. Epub 2012 Jul 31.

14.

Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.

Park I, Lupo JM, Nelson SJ.

Mol Imaging Biol. 2018 Sep 17. doi: 10.1007/s11307-018-1275-y. [Epub ahead of print]

PMID:
30225760
15.

13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.

Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Clin Cancer Res. 2015 Nov 15;21(22):5073-81. doi: 10.1158/1078-0432.CCR-14-1717. Epub 2015 Feb 11.

16.

Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor.

Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J.

NMR Biomed. 2015 Sep;28(9):1141-9. doi: 10.1002/nbm.3354. Epub 2015 Jul 23.

17.

Detection of inflammatory arthritis by using hyperpolarized 13C-pyruvate with MR imaging and spectroscopy.

MacKenzie JD, Yen YF, Mayer D, Tropp JS, Hurd RE, Spielman DM.

Radiology. 2011 May;259(2):414-20. doi: 10.1148/radiol.10101921. Epub 2011 Mar 15.

18.

A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.

El Meskini R, Iacovelli AJ, Kulaga A, Gumprecht M, Martin PL, Baran M, Householder DB, Van Dyke T, Weaver Ohler Z.

Dis Model Mech. 2015 Jan;8(1):45-56. doi: 10.1242/dmm.018168. Epub 2014 Nov 27.

19.

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth.

Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM.

Clin Cancer Res. 2010 Jan 1;16(1):154-63. doi: 10.1158/1078-0432.CCR-09-2850.

20.

Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study.

Colen CB, Shen Y, Ghoddoussi F, Yu P, Francis TB, Koch BJ, Monterey MD, Galloway MP, Sloan AE, Mathupala SP.

Neoplasia. 2011 Jul;13(7):620-32.

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