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Items: 1 to 20 of 81

1.

Long-range effects of a peripheral mutation on the enzymatic activity of cytochrome P450 1A2.

Zhang T, Liu LA, Lewis DF, Wei DQ.

J Chem Inf Model. 2011 Jun 27;51(6):1336-46. doi: 10.1021/ci200112b. Epub 2011 May 20.

PMID:
21598960
2.

Prediction of three-dimensional structures and structural flexibilities of wild-type and mutant cytochrome P450 1A2 using molecular dynamics simulations.

Watanabe Y, Fukuyoshi S, Hiratsuka M, Yamaotsu N, Hirono S, Takahashi O, Oda A.

J Mol Graph Model. 2016 Jul;68:48-56. doi: 10.1016/j.jmgm.2016.06.006. Epub 2016 Jun 16.

PMID:
27371932
3.

A theoretical study on the mechanism of a superficial mutation inhibiting the enzymatic activity of CYP1A2.

Ma LN, Du ZZ, Lian P, Wei DQ.

Interdiscip Sci. 2014 Mar;6(1):25-31. doi: 10.1007/s12539-014-0184-2. Epub 2014 Jan 28.

PMID:
24464701
5.

The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism.

Liu J, Ericksen SS, Sivaneri M, Besspiata D, Fisher CW, Szklarz GD.

Arch Biochem Biophys. 2004 Apr 1;424(1):33-43.

PMID:
15019834
6.

Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.

Narimatsu S, Oda M, Hichiya H, Isobe T, Asaoka K, Hanioka N, Yamano S, Shinoda S, Yamamoto S.

Chem Biol Interact. 2005 Feb 28;152(1):1-12.

PMID:
15766918
8.

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.

Yun CH, Miller GP, Guengerich FP.

Biochemistry. 2000 Sep 19;39(37):11319-29.

PMID:
10985777
9.

Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands.

Vasanthanathan P, Hritz J, Taboureau O, Olsen L, Jørgensen FS, Vermeulen NP, Oostenbrink C.

J Chem Inf Model. 2009 Jan;49(1):43-52. doi: 10.1021/ci800371f.

PMID:
19099399
10.

Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations.

He L, He F, Bi H, Li J, Zeng S, Luo HB, Huang M.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6008-12. doi: 10.1016/j.bmcl.2010.08.072. Epub 2010 Aug 20.

PMID:
20832301
11.
12.

Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.

Murayama N, Soyama A, Saito Y, Nakajima Y, Komamura K, Ueno K, Kamakura S, Kitakaze M, Kimura H, Goto Y, Saitoh O, Katoh M, Ohnuma T, Kawai M, Sugai K, Ohtsuki T, Suzuki C, Minami N, Ozawa S, Sawada J.

J Pharmacol Exp Ther. 2004 Jan;308(1):300-6. Epub 2003 Oct 16. Erratum in: J Pharmacol Exp Ther. 2004 Mar;308(3):1219.

PMID:
14563787
13.

Application of molecular modeling for prediction of substrate specificity in cytochrome P450 1A2 mutants.

Tu Y, Deshmukh R, Sivaneri M, Szklarz GD.

Drug Metab Dispos. 2008 Nov;36(11):2371-80. doi: 10.1124/dmd.108.022640. Epub 2008 Aug 14.

14.

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli.

Kim DH, Kim KH, Isin EM, Guengerich FP, Chae HZ, Ahn T, Yun CH.

Protein Expr Purif. 2008 Feb;57(2):188-200. Epub 2007 Oct 22.

PMID:
18032064
15.

Conformational change of cytochrome P450 1A2 induced by phospholipids and detergents.

Yun CH, Song M, Kim H.

J Biol Chem. 1997 Aug 8;272(32):19725-30.

16.

Molecular basis of proton uptake in single and double mutants of cytochrome c oxidase.

Henry RM, Caplan D, Fadda E, Pomès R.

J Phys Condens Matter. 2011 Jun 15;23(23):234102. doi: 10.1088/0953-8984/23/23/234102. Epub 2011 May 25.

PMID:
21613706
17.

Distal site and surface mutations of cytochrome P450 1A2 markedly enhance dehalogenation of chlorinated hydrocarbons.

Yanagita K, Sagami I, Shimizu T.

Arch Biochem Biophys. 1997 Oct 15;346(2):269-76.

PMID:
9343374
18.

Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties.

Parikh A, Josephy PD, Guengerich FP.

Biochemistry. 1999 Apr 27;38(17):5283-9.

PMID:
10220313
19.

Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues.

Guengerich FP, Humphreys WG, Yun CH, Hammons GJ, Kadlubar FF, Seto Y, Okazaki O, Martin MV.

Princess Takamatsu Symp. 1995;23:78-84. Review.

PMID:
8844798
20.

7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes.

Yamazaki H, Inoue K, Mimura M, Oda Y, Guengerich FP, Shimada T.

Biochem Pharmacol. 1996 Feb 9;51(3):313-9.

PMID:
8573198

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