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Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.

Stevenson WS, Hyland CD, Zhang JG, Morgan PO, Willson TA, Gill A, Hilton AA, Viney EM, Bahlo M, Masters SL, Hennebry S, Richardson SJ, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS.

Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16625-30. doi: 10.1073/pnas.1010390107. Epub 2010 Sep 7.


Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.

Ramazzina I, Folli C, Secchi A, Berni R, Percudani R.

Nat Chem Biol. 2006 Mar;2(3):144-8. Epub 2006 Feb 5.


Mouse transthyretin-related protein is a hydrolase which degrades 5-hydroxyisourate, the end product of the uricase reaction.

Lee Y, Park BC, Lee DH, Bae KH, Cho S, Lee CH, Lee JS, Myung PK, Park SG.

Mol Cells. 2006 Oct 31;22(2):141-5.


Absolute stereochemistry and preferred conformations of urate degradation intermediates from computed and experimental circular dichroism spectra.

Pipolo S, Percudani R, Cammi R.

Org Biomol Chem. 2011 Jul 21;9(14):5149-55. doi: 10.1039/c1ob05433c. Epub 2011 Jun 7. Erratum in: Org Biomol Chem. 2016 Apr 14;14(14):3654.


A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase.

Raychaudhuri A, Tipton PA.

Biochemistry. 2003 Jun 10;42(22):6848-52.


The crystal structure of the transthyretin-like protein from Salmonella dublin, a prokaryote 5-hydroxyisourate hydrolase.

Hennebry SC, Law RH, Richardson SJ, Buckle AM, Whisstock JC.

J Mol Biol. 2006 Jun 23;359(5):1389-99. Epub 2006 May 11.


Recapture of [S]-allantoin, the product of the two-step degradation of uric acid, by urate oxidase.

Gabison L, Chiadmi M, Colloc'h N, Castro B, El Hajji M, Prangé T.

FEBS Lett. 2006 Apr 3;580(8):2087-91. Epub 2006 Mar 10.


Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses.

Kasai K, Nishiyama N, Yamauchi K.

Gene. 2013 Dec 1;531(2):326-36. doi: 10.1016/j.gene.2013.08.071. Epub 2013 Aug 30.


Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.

Wu X, Wakamiya M, Vaishnav S, Geske R, Montgomery C Jr, Jones P, Bradley A, Caskey CT.

Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):742-6.


Transformation of epithelial cells stably transfected with H2O2-generating peroxisomal urate oxidase.

Chu R, Lin Y, Reddy KC, Pan J, Rao MS, Reddy JK, Yeldandi AV.

Cancer Res. 1996 Nov 1;56(21):4846-52.


Arxula adeninivorans recombinant urate oxidase and its application in the production of food with low uric acid content.

Trautwein-Schult A, Jankowska D, Cordes A, Hoferichter P, Klein C, Matros A, Mock HP, Baronian K, Bode R, Kunze G.

J Mol Microbiol Biotechnol. 2013;23(6):418-30. doi: 10.1159/000353847. Epub 2013 Sep 6.


Cloning and expression of a urate oxidase and creatinine hydrolase fusion gene in Escherichia coli.

Cheng X, Liu F, Zhang Y, Jiang Y.

Ren Fail. 2013;35(2):275-8. doi: 10.3109/0886022X.2012.745787. Epub 2013 Jan 9.


Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.

Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, Taketo MM.

Cancer Res. 2002 Apr 1;62(7):1971-7.


Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction.

Lee Y, Lee DH, Kho CW, Lee AY, Jang M, Cho S, Lee CH, Lee JS, Myung PK, Park BC, Park SG.

FEBS Lett. 2005 Aug 29;579(21):4769-74.


Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.

Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, Isomura Y, Seto M, Nakagawa H, Asaoka Y, Tada M, Ohta M, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Maeda S, Shiina S, Yoshida H, Nakajima O, Kanai F, Omata M, Koike K.

J Hepatol. 2011 Dec;55(6):1400-8. doi: 10.1016/j.jhep.2011.03.025. Epub 2011 May 19.


Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism.

Mohanty SK, Yu CL, Das S, Louie TM, Gakhar L, Subramanian M.

J Bacteriol. 2012 Aug;194(15):3872-82. doi: 10.1128/JB.00597-12. Epub 2012 May 18.


Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis.

Okumura I, Kondo K, Miyake Y, Itaya K, Yamamoto T.

J Biochem. 1976 May;79(5):1013-9.


Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae.

French JB, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):671-7. doi: 10.1107/S090744491101746X. Epub 2011 Jul 12.


Intrinsic reactivity of uric acid with dioxygen: Towards the elucidation of the catalytic mechanism of urate oxidase.

Altarsha M, Castro B, Monard G.

Bioorg Chem. 2009 Aug;37(4):111-25. doi: 10.1016/j.bioorg.2009.05.004. Epub 2009 May 29.


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