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Items: 1 to 20 of 131

1.

Synthesis and biological activity of 7-deaza-7-ethynyl-2'-deoxy-2'-fluoro-2'-C-methyladenosine and its 2'-C-methyl-ribo analogue.

Prhavc M, Dyatkina N, Keicher J, Liehr S, Koo-McCoy S, Latour D, Fung K, Dunlop K, Pouliot J, Wang T, Li W, Lou L, Roberts C, Griffith R.

Nucleic Acids Symp Ser (Oxf). 2008;(52):643-4. doi: 10.1093/nass/nrn325.

PMID:
18776544
2.

Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.

Hu W, Wang P, Song C, Pan Z, Wang Q, Guo X, Yu X, Shen Z, Wang S, Chang J.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7297-8. doi: 10.1016/j.bmcl.2010.10.076. Epub 2010 Nov 4.

PMID:
21106452
3.

A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.

Liu J, Du J, Wang P, Nagarathnam D, Espiritu CL, Bao H, Murakami E, Furman PA, Sofia MJ.

Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):277-85. doi: 10.1080/15257770.2012.658131.

PMID:
22444190
4.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA.

J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x.

PMID:
20845908
5.

Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus.

Koh YH, Shim JH, Wu JZ, Zhong W, Hong Z, Girardet JL.

J Med Chem. 2005 Apr 21;48(8):2867-75.

PMID:
15828825
6.

Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.

Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2007 Feb;51(2):503-9. Epub 2006 Nov 13.

7.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

Reddy PG, Bao D, Chang W, Chun BK, Du J, Nagarathnam D, Rachakonda S, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7376-80. doi: 10.1016/j.bmcl.2010.10.035. Epub 2010 Oct 15.

PMID:
21050754
8.

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

Jonckers TH, Lin TI, Buyck C, Lachau-Durand S, Vandyck K, Van Hoof S, Vandekerckhove LA, Hu L, Berke JM, Vijgen L, Dillen LL, Cummings MD, de Kock H, Nilsson M, Sund C, Rydegård C, Samuelsson B, Rosenquist A, Fanning G, Van Emelen K, Simmen K, Raboisson P.

J Med Chem. 2010 Nov 25;53(22):8150-60. doi: 10.1021/jm101050a. Epub 2010 Oct 29.

PMID:
21033671
9.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.

de Vicente J, Hendricks RT, Smith DB, Fell JB, Fischer J, Spencer SR, Stengel PJ, Mohr P, Robinson JE, Blake JF, Hilgenkamp RK, Yee C, Adjabeng G, Elworthy TR, Li J, Wang B, Bamberg JT, Harris SF, Wong A, Leveque VJ, Najera I, Le Pogam S, Rajyaguru S, Ao-Ieong G, Alexandrova L, Larrabee S, Brandl M, Briggs A, Sukhtankar S, Farrell R.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5652-6. doi: 10.1016/j.bmcl.2009.08.022. Epub 2009 Aug 8.

PMID:
19709881
10.

Stereoselective synthesis and biological evaluations of novel 3'-deoxy-4'-azaribonucleosides as inhibitors of hepatitis C virus RNA replication.

Chiacchio U, Borrello L, Crispino L, Rescifina A, Merino P, Macchi B, Balestrieri E, Mastino A, Piperno A, Romeo G.

J Med Chem. 2009 Jul 9;52(13):4054-7. doi: 10.1021/jm900197j.

PMID:
19419173
11.

Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Beaulieu PL, Bousquet Y, Gauthier J, Gillard J, Marquis M, McKercher G, Pellerin C, Valois S, Kukolj G.

J Med Chem. 2004 Dec 30;47(27):6884-92.

PMID:
15615537
12.

Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.

Di Francesco ME, Avolio S, Pompei M, Pesci S, Monteagudo E, Pucci V, Giuliano C, Fiore F, Rowley M, Summa V.

Bioorg Med Chem. 2012 Aug 1;20(15):4801-11. doi: 10.1016/j.bmc.2012.05.067. Epub 2012 Jun 6.

PMID:
22770556
13.

Evaluation of inhibitory effects of thiobarbituric acid derivatives targeting HCV NS5B polymerase.

Lee JH, Lee S, Park MY, Ha HJ, Myung H.

J Microbiol Biotechnol. 2010 Mar;20(3):510-2.

14.

Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.

Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J.

J Med Chem. 2007 May 3;50(9):2108-16. Epub 2007 Apr 3. Erratum in: J Med Chem. 2007 Nov 29;50(24):6290.

PMID:
17402724
15.

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Tharnish PM, McBrayer TR, Stuyver LJ, Otto MJ, Chu CK, Schinazi RF, Watanabe KA.

Bioorg Med Chem. 2005 Mar 1;13(5):1641-52.

PMID:
15698782
16.

Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.

Reddy PG, Chun BK, Zhang HR, Rachakonda S, Ross BS, Sofia MJ.

J Org Chem. 2011 May 20;76(10):3782-90. doi: 10.1021/jo200060f. Epub 2011 Apr 19.

PMID:
21469736
17.

6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors.

Gunic E, Chow S, Rong F, Ramasamy K, Raney A, Li DY, Huang J, Hamatake RK, Hong Z, Girardet JL.

Bioorg Med Chem Lett. 2007 May 1;17(9):2456-8. Epub 2007 Feb 14.

PMID:
17331718
18.

Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.

Leroy F, Chaves D, Dukhan D, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):595-6. doi: 10.1093/nass/nrn301.

PMID:
18776520
19.

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.

Cho A, Saunders OL, Butler T, Zhang L, Xu J, Vela JE, Feng JY, Ray AS, Kim CU.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. doi: 10.1016/j.bmcl.2012.02.105. Epub 2012 Mar 8.

PMID:
22446091
20.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149

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