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Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors.

Perrin MH, Grace CR, Digruccio MR, Fischer WH, Maji SK, Cantle JP, Smith S, Manning G, Vale WW, Riek R.

J Biol Chem. 2007 Dec 28;282(52):37529-36. Epub 2007 Oct 16.


Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand.

Grace CR, Perrin MH, Gulyas J, Digruccio MR, Cantle JP, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4858-63. Epub 2007 Mar 12.


NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.

Grace CR, Perrin MH, Gulyas J, Rivier JE, Vale WW, Riek R.

J Biol Chem. 2010 Dec 3;285(49):38580-9. doi: 10.1074/jbc.M110.121897. Epub 2010 Sep 15.


A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity.

Perrin MH, DiGruccio MR, Koerber SC, Rivier JE, Kunitake KS, Bain DL, Fischer WH, Vale WW.

J Biol Chem. 2003 May 2;278(18):15595-600. Epub 2003 Feb 28.


NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.

Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R.

Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12836-41. Epub 2004 Aug 23.


A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.

Cook JV, McGregor A, Lee T, Milligan G, Eidne KA.

Endocrinology. 1996 Jul;137(7):2851-8.


Common and divergent structural features of a series of corticotropin releasing factor-related peptides.

Grace CR, Perrin MH, Cantle JP, Vale WW, Rivier JE, Riek R.

J Am Chem Soc. 2007 Dec 26;129(51):16102-14. Epub 2007 Dec 6.


Extracellular cysteines of the corticotropin-releasing factor receptor are critical for ligand interaction.

Qi LJ, Leung AT, Xiong Y, Marx KA, Abou-Samra AB.

Biochemistry. 1997 Oct 14;36(41):12442-8.


Impact of N-terminal domains for corticotropin-releasing factor (CRF) receptor-ligand interactions.

Klose J, Fechner K, Beyermann M, Krause E, Wendt N, Bienert M, Rudolph R, Rothemund S.

Biochemistry. 2005 Feb 8;44(5):1614-23.


Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding.

Gkountelias K, Tselios T, Venihaki M, Deraos G, Lazaridis I, Rassouli O, Gravanis A, Liapakis G.

Mol Pharmacol. 2009 Apr;75(4):793-800. doi: 10.1124/mol.108.052423. Epub 2009 Jan 5.


Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling.

Tan YV, Couvineau A, Murail S, Ceraudo E, Neumann JM, Lacapère JJ, Laburthe M.

J Biol Chem. 2006 May 5;281(18):12792-8. Epub 2006 Mar 6.


Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation.

Janovick JA, Pogozheva ID, Mosberg HI, Conn PM.

J Pharmacol Exp Ther. 2011 Aug;338(2):430-42. doi: 10.1124/jpet.111.180869. Epub 2011 Apr 28.


Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1.

Huising MO, Vaughan JM, Shah SH, Grillot KL, Donaldson CJ, Rivier J, Flik G, Vale WW.

J Biol Chem. 2008 Apr 4;283(14):8902-12. doi: 10.1074/jbc.M709904200. Epub 2008 Jan 29.


Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant.

Myers DA, Trinh JV, Myers TR.

Mol Cell Endocrinol. 1998 Sep 25;144(1-2):21-35.


Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide.

Rathmann D, Lindner D, DeLuca SH, Kaufmann KW, Meiler J, Beck-Sickinger AG.

J Biol Chem. 2012 Sep 14;287(38):32181-94. doi: 10.1074/jbc.M112.349852. Epub 2012 Jul 9.


Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.

Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

FASEB J. 2012 Dec;26(12):5092-105. doi: 10.1096/fj.12-212399. Epub 2012 Sep 10.


Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor.

Perrin MH, Fischer WH, Kunitake KS, Craig AG, Koerber SC, Cervini LA, Rivier JE, Groppe JC, Greenwald J, Møller Nielsen S, Vale WW.

J Biol Chem. 2001 Aug 24;276(34):31528-34. Epub 2001 Jun 25.

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