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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice.

Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J.

Mol Cell Biol. 2005 Nov;25(22):10079-86.


53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3310-5. Epub 2006 Feb 21.


PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.

Rybanska I, Ishaq O, Chou J, Prakash M, Bakhsheshian J, Huso DL, Franco S.

Oncogene. 2013 Apr 4;32(14):1761-71. doi: 10.1038/onc.2012.199. Epub 2012 May 21.


Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.

Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW.

Cell. 2003 Aug 8;114(3):359-70.


p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks.

Schultz LB, Chehab NH, Malikzay A, Halazonetis TD.

J Cell Biol. 2000 Dec 25;151(7):1381-90.


Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.

Takeyama K, Monti S, Manis JP, Dal Cin P, Getz G, Beroukhim R, Dutt S, Aster JC, Alt FW, Golub TR, Shipp MA.

Oncogene. 2008 Jan 10;27(3):318-22. Epub 2007 Jul 16.


Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.

Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG.

DNA Repair (Amst). 2007 Sep 1;6(9):1243-54. Epub 2007 Mar 21.


Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.

Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW.

Blood. 2008 Feb 15;111(4):2163-9. Epub 2007 Sep 13.


Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2011 May 6;42(3):319-29. doi: 10.1016/j.molcel.2011.03.019.


H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.


53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation.

Rybanska-Spaeder I, Reynolds TL, Chou J, Prakash M, Jefferson T, Huso DL, Desiderio S, Franco S.

Mol Cancer Res. 2013 Oct;11(10):1223-34. doi: 10.1158/1541-7786.MCR-13-0252-T. Epub 2013 Jul 15.


Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R.

Mol Cell. 2007 Dec 28;28(6):1045-57.


53BP1, an activator of ATM in response to DNA damage.

Mochan TA, Venere M, DiTullio RA Jr, Halazonetis TD.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):945-52.


Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA.

Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, Cao Y, Hamada T, Imamura K, Jeggo PA, Date T, Doherty AJ.

J Biol Chem. 2003 Sep 19;278(38):36487-95. Epub 2003 Jun 24.


53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A.

Nature. 2008 Nov 27;456(7221):529-33. doi: 10.1038/nature07476. Epub 2008 Oct 19.


Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways.

Rappold I, Iwabuchi K, Date T, Chen J.

J Cell Biol. 2001 Apr 30;153(3):613-20. Erratum in: J Cell Biol 2001 Jul 23;154(2):469.


Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1.

Bekker-Jensen S, Lukas C, Melander F, Bartek J, Lukas J.

J Cell Biol. 2005 Jul 18;170(2):201-11. Epub 2005 Jul 11.


53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

Pryde F, Khalili S, Robertson K, Selfridge J, Ritchie AM, Melton DW, Jullien D, Adachi Y.

J Cell Sci. 2005 May 1;118(Pt 9):2043-55. Epub 2005 Apr 19.


H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.

Cell. 2003 Aug 8;114(3):371-383.


Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model.

Liang Y, Gao H, Lin SY, Goss JA, Du C, Li K.

Oncogene. 2015 Aug 13;34(33):4368-78. doi: 10.1038/onc.2014.367. Epub 2014 Nov 3.

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