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Items: 1 to 20 of 174

1.

New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives.

Bradbury RH, Allott CP, Dennis M, Fisher E, Major JS, Masek BB, Oldham AA, Pearce RJ, Rankine N, Revill JM, et al.

J Med Chem. 1992 Oct 30;35(22):4027-38.

PMID:
1433210
2.

New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives.

Bradbury RH, Allott CP, Dennis M, Girdwood JA, Kenny PW, Major JS, Oldham AA, Ratcliffe AH, Rivett JE, Roberts DA, et al.

J Med Chem. 1993 Apr 30;36(9):1245-54.

PMID:
8487261
4.

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles.

Kubo K, Inada Y, Kohara Y, Sugiura Y, Ojima M, Itoh K, Furukawa Y, Nishikawa K, Naka T.

J Med Chem. 1993 Jun 11;36(12):1772-84.

PMID:
8510105
5.

New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives.

Thomas AP, Allott CP, Gibson KH, Major JS, Masek BB, Oldham AA, Ratcliffe AH, Roberts DA, Russell ST, Thomason DA.

J Med Chem. 1992 Mar 6;35(5):877-85.

PMID:
1548677
6.

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.

Kubo K, Kohara Y, Imamiya E, Sugiura Y, Inada Y, Furukawa Y, Nishikawa K, Naka T.

J Med Chem. 1993 Jul 23;36(15):2182-95.

PMID:
8340921
7.

Nonpeptide angiotensin II receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.

Yanagisawa H, Amemiya Y, Kanazaki T, Shimoji Y, Fujimoto K, Kitahara Y, Sada T, Mizuno M, Ikeda M, Miyamoto S, Furukawa Y, Koike H.

J Med Chem. 1996 Jan 5;39(1):323-38.

PMID:
8568823
8.

Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (imidazolylbiphenylyl)sulfonylurea (HR 720).

Deprez P, Guillaume J, Becker R, Corbier A, Didierlaurent S, Fortin M, Frechet D, Hamon G, Heckmann B, Heitsch H, et al.

J Med Chem. 1995 Jun 23;38(13):2357-77.

PMID:
7608902
9.

Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles.

Almansa C, Gómez LA, Cavalcanti FL, de Arriba AF, García-Rafanell J, Forn J.

J Med Chem. 1997 Feb 14;40(4):547-58.

PMID:
9046346
10.

Dihydropyrimidine angiotensin II receptor antagonists.

Atwal KS, Ahmed SZ, Bird JE, Delaney CL, Dickinson KE, Ferrara FN, Hedberg A, Miller AV, Moreland S, O'Reilly BC, et al.

J Med Chem. 1992 Dec 11;35(25):4751-63.

PMID:
1469703
11.

Synthesis and angiotensin II receptor antagonist activity of C-linked pyrazole derivatives.

Nicolaï E, Curé G, Goyard J, Kirchner M, Teulon JM, Versigny A, Cazes M, Virone-Oddos A, Caussade F, Cloarec A.

Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1617-30.

PMID:
7954914
12.

Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.

Almansa C, Gómez LA, Cavalcanti FL, de Arriba AF, Rodríguez R, Carceller E, García-Rafanell J, Forn J.

J Med Chem. 1996 May 24;39(11):2197-206.

PMID:
8667363
13.

Pharmacologic profiles of KRH-594, a novel nonpeptide angiotensin II-receptor antagonist.

Tamura K, Okuhira M, Amano H, Inokuma K, Hirata T, Mikoshiba I, Hashimoto K.

J Cardiovasc Pharmacol. 1997 Nov;30(5):607-15.

PMID:
9388043
14.

Studies on nonpeptide angiotensin II receptor antagonists. I. Synthesis and biological evaluation of pyrazolo[1,5-b][1,2,4]triazole derivatives with alkyl substituents.

Okazaki T, Suga A, Watanabe T, Kikuchi K, Kurihara H, Shibasaki M, Fujimori A, Inagaki O, Yanagisawa U.

Chem Pharm Bull (Tokyo). 1998 Jan;46(1):69-78.

PMID:
9468638
15.

Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.

Ashton WT, Cantone CL, Chang LL, Hutchins SM, Strelitz RA, MacCoss M, Chang RS, Lotti VJ, Faust KA, Chen TB, et al.

J Med Chem. 1993 Mar 5;36(5):591-609.

PMID:
8496939
16.

Pharmacological properties of KT3-671, a novel nonpeptide angiotensin II receptor antagonist.

Mochizuki S, Sato T, Furuta K, Hase K, Ohkura Y, Fukai C, Kosakai K, Wakabayashi S, Tomiyama A.

J Cardiovasc Pharmacol. 1995 Jan;25(1):22-9.

PMID:
7723348
17.

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.

Criscione L, de Gasparo M, Bühlmayer P, Whitebread S, Ramjoué HP, Wood J.

Br J Pharmacol. 1993 Oct;110(2):761-71.

18.

Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure.

Cappelli A, Pericot Mohr Gl Gl, Gallelli A, Rizzo M, Anzini M, Vomero S, Mennuni L, Ferrari F, Makovec F, Menziani MC, De Benedetti PG, Giorgi G.

J Med Chem. 2004 May 6;47(10):2574-86.

PMID:
15115399
19.

The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.

Duncia JV, Chiu AT, Carini DJ, Gregory GB, Johnson AL, Price WA, Wells GJ, Wong PC, Calabrese JC, Timmermans PB.

J Med Chem. 1990 May;33(5):1312-29.

PMID:
2329553
20.

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al.

J Med Chem. 1995 Sep 15;38(19):3759-71.

PMID:
7562906

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