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hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

Billecke SS, Bender AT, Kanelakis KC, Murphy PJ, Lowe ER, Kamada Y, Pratt WB, Osawa Y.

J Biol Chem. 2002 Jun 7;277(23):20504-9. Epub 2002 Mar 28.


Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo.

Bender AT, Silverstein AM, Demady DR, Kanelakis KC, Noguchi S, Pratt WB, Osawa Y.

J Biol Chem. 1999 Jan 15;274(3):1472-8.


The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.

Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y.

J Biol Chem. 2004 Jul 16;279(29):30252-8. Epub 2004 May 19.


Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy.

Song Y, Zweier JL, Xia Y.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C1819-24.


Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin.

Schulte TW, Akinaga S, Soga S, Sullivan W, Stensgard B, Toft D, Neckers LM.

Cell Stress Chaperones. 1998 Jun;3(2):100-8.


Functional interdependence and colocalization of endothelial nitric oxide synthase and heat shock protein 90 in cerebral arteries.

Khurana VG, Feterik K, Springett MJ, Eguchi D, Shah V, Katusic ZS.

J Cereb Blood Flow Metab. 2000 Nov;20(11):1563-70.


Hsp90 chaperones wild-type p53 tumor suppressor protein.

Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M.

J Biol Chem. 2004 Nov 19;279(47):48836-45. Epub 2004 Sep 9.


Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.

Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y.

Biochemistry. 2011 Aug 23;50(33):7146-56. doi: 10.1021/bi200751t. Epub 2011 Jul 21.


Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.

Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR.

Anesthesiology. 2009 Feb;110(2):317-25. doi: 10.1097/ALN.0b013e3181942cb4. Erratum in: Anesthesiology. 2009 Jun;110(6):1435.


Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle.

Han G, Ma H, Chintala R, Fulton DJ, Barman SA, White RE.

J Pharmacol Exp Ther. 2009 Jun;329(3):850-5. doi: 10.1124/jpet.108.149112. Epub 2009 Mar 17.


Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation.

Song Y, Cardounel AJ, Zweier JL, Xia Y.

Biochemistry. 2002 Aug 27;41(34):10616-22.


Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH.

J Med Chem. 1999 Jan 28;42(2):260-6.


Role of heat shock protein 90 in bradykinin-stimulated endothelial nitric oxide release.

Harris MB, Ju H, Venema VJ, Blackstone M, Venema RC.

Gen Pharmacol. 2000 Sep;35(3):165-70.


Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.

Peng HM, Morishima Y, Pratt WB, Osawa Y.

J Biol Chem. 2012 Jan 6;287(2):1556-65. doi: 10.1074/jbc.M111.323295. Epub 2011 Nov 28.


Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

Brouet A, Sonveaux P, Dessy C, Moniotte S, Balligand JL, Feron O.

Circ Res. 2001 Nov 9;89(10):866-73.


Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.

Peng HM, Morishima Y, Clapp KM, Lau M, Pratt WB, Osawa Y.

Biochemistry. 2009 Sep 8;48(35):8483-90. doi: 10.1021/bi901058g.


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