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Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex.

Grenon M, Gilbert C, Lowndes NF.

Nat Cell Biol. 2001 Sep;3(9):844-7.


Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation.

Grenon M, Magill CP, Lowndes NF, Jackson SP.

FEMS Yeast Res. 2006 Aug;6(5):836-47.


Arsenic-induced Mre11 phosphorylation is cell cycle-dependent and defective in NBS cells.

Yuan SS, Su JH, Hou MF, Yang FW, Zhao S, Lee EY.

DNA Repair (Amst). 2002 Feb 28;1(2):137-42.


Complex formation and functional versatility of Mre11 of budding yeast in recombination.

Usui T, Ohta T, Oshiumi H, Tomizawa J, Ogawa H, Ogawa T.

Cell. 1998 Nov 25;95(5):705-16.


Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT.

J Biol Chem. 2003 Nov 14;278(46):45171-81. Epub 2003 Sep 8.


The fission yeast Rad32 (Mre11)-Rad50-Nbs1 complex is required for the S-phase DNA damage checkpoint.

Chahwan C, Nakamura TM, Sivakumar S, Russell P, Rhind N.

Mol Cell Biol. 2003 Sep;23(18):6564-73.


Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.

Trujillo KM, Roh DH, Chen L, Van Komen S, Tomkinson A, Sung P.

J Biol Chem. 2003 Dec 5;278(49):48957-64. Epub 2003 Sep 30.


Mre11 mediates gene regulation in yeast spore development.

Kugou K, Sasanuma H, Matsumoto K, Shirahige K, Ohta K.

Genes Genet Syst. 2007 Feb;82(1):21-33.


Mutations in the MRE11, RAD50, XRS2, and MRE2 genes alter chromatin configuration at meiotic DNA double-stranded break sites in premeiotic and meiotic cells.

Ohta K, Nicolas A, Furuse M, Nabetani A, Ogawa H, Shibata T.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):646-51.


Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

Lisby M, Barlow JH, Burgess RC, Rothstein R.

Cell. 2004 Sep 17;118(6):699-713.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy.

Anderson DE, Trujillo KM, Sung P, Erickson HP.

J Biol Chem. 2001 Oct 5;276(40):37027-33. Epub 2001 Jul 24.


DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.

Trujillo KM, Sung P.

J Biol Chem. 2001 Sep 21;276(38):35458-64. Epub 2001 Jul 13.


Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection.

Yu TY, Kimble MT, Symington LS.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11961-E11969. doi: 10.1073/pnas.1816539115. Epub 2018 Dec 3.


Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway.

Nakada D, Hirano Y, Sugimoto K.

Mol Cell Biol. 2004 Nov;24(22):10016-25.

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