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Items: 1 to 20 of 358

1.

SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.

Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Decobert M, Françon D, Avenet P, Depoortere H, Tan S, Oblin A, Schoemaker H, Evanno Y, Sevrin M, George P, Scatton B.

J Pharmacol Exp Ther. 2001 Aug;298(2):753-68.

PMID:
11454940
2.

SL651498, a GABAA receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms.

Griebel G, Perrault G, Simiand J, Cohen C, Granger P, Depoortere H, Françon D, Avenet P, Schoemaker H, Evanno Y, Sevrin M, George P, Scatton B.

CNS Drug Rev. 2003 Spring;9(1):3-20. Review.

4.

Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.

Atack JR.

Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):213-32. Review.

PMID:
12871032
5.

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.

J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. Epub 2006 Sep 13.

PMID:
16971504
7.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM.

J Pharmacol Exp Ther. 2006 Jan;316(1):410-22. Epub 2005 Sep 23.

PMID:
16183706
8.

5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.

Dubinsky B, Vaidya AH, Rosenthal DI, Hochman C, Crooke JJ, DeLuca S, DeVine A, Cheo-Isaacs CT, Carter AR, Jordan AD, Reitz AB, Shank RP.

J Pharmacol Exp Ther. 2002 Nov;303(2):777-90.

PMID:
12388665
9.

GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin.

Wang F, Xu Z, Ren L, Tsang SY, Xue H.

Neuropharmacology. 2008 Dec;55(7):1231-7. doi: 10.1016/j.neuropharm.2008.07.040. Epub 2008 Aug 5.

PMID:
18723037
11.

Comparison of the pharmacological properties of classical and novel BZ-omega receptor ligands.

Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ.

Behav Pharmacol. 1999 Sep;10(5):483-95.

PMID:
10780255
12.

RP 59037 and RP 60503: anxiolytic cyclopyrrolone derivatives with low sedative potential. interaction with the gamma-aminobutyric acidA/benzodiazepine receptor complex and behavioral effects in the rodent.

Doble A, Canton T, Dreisler S, Piot O, Boireau A, Stutzmann JM, Bardone MC, Rataud J, Roux M, Roussel G, et al.

J Pharmacol Exp Ther. 1993 Sep;266(3):1213-26.

PMID:
8103792
13.

Pharmacological studies on synthetic flavonoids: comparison with diazepam.

Griebel G, Perrault G, Tan S, Schoemaker H, Sanger DJ.

Neuropharmacology. 1999 Jul;38(7):965-77.

PMID:
10428415
14.
15.

The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone.

Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM, Dawson GR, Wafford KA, Reynolds DS.

Neuropharmacology. 2006 May;50(6):677-89. Epub 2006 Jan 20.

PMID:
16430927
16.

Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.

Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU.

Pain. 2009 Feb;141(3):233-8. doi: 10.1016/j.pain.2008.10.015. Epub 2008 Dec 16.

PMID:
19091469
17.

6,3'-Dinitroflavone is a low efficacy modulator of GABA(A) receptors.

Furtmueller R, Furtmueller B, Ramerstorfer J, Paladini AC, Wasowski C, Marder M, Huck S, Sieghart W.

Eur J Pharmacol. 2008 Sep 4;591(1-3):142-6. doi: 10.1016/j.ejphar.2008.06.093. Epub 2008 Jul 2.

PMID:
18639544
18.

3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes.

Karim N, Gavande N, Wellendorph P, Johnston GA, Hanrahan JR, Chebib M.

Biochem Pharmacol. 2011 Dec 15;82(12):1971-83. doi: 10.1016/j.bcp.2011.09.002. Epub 2011 Sep 8.

PMID:
21924247
19.

Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives.

Auta J, Kadriu B, Giusti P, Costa E, Guidotti A.

Pharmacol Biochem Behav. 2010 Jun;95(4):383-9. doi: 10.1016/j.pbb.2010.02.016. Epub 2010 Mar 19.

PMID:
20227434
20.

The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics.

Atack JR.

Expert Opin Investig Drugs. 2005 May;14(5):601-18. Review.

PMID:
15926867

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