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Items: 1 to 20 of 1444

1.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968
2.

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain.

Sznejder-Pachołek A, Joniec-Maciejak I, Wawer A, Ciesielska A, Mirowska-Guzel D.

Pharmacol Rep. 2017 Apr;69(2):242-251. doi: 10.1016/j.pharep.2016.11.003. Epub 2016 Nov 9.

PMID:
28126640
3.

[Neuropathology and pathophysiology of Parkinson's disease: Focus on α-synuclein].

Prigent A, Lionnet A, Corbillé AG, Derkinderen P.

Presse Med. 2017 Mar;46(2 Pt 1):182-186. doi: 10.1016/j.lpm.2016.11.010. Epub 2016 Dec 28. French.

PMID:
28040347
4.

α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects.

Kim JS, Park IS, Park HE, Kim SY, Yun JA, Jung CK, Sung HY, Lee JK, Kang WK.

Neurol Sci. 2017 Jan;38(1):171-179. doi: 10.1007/s10072-016-2745-0. Epub 2016 Nov 1.

PMID:
27803984
5.

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.

Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, Andrabi SA, Kang SU, Gonçalves RA, Liang Y, Zhang S, Qi C, Lam S, Keiler JA, Tyson J, Kim D, Panicker N, Yun SP, Workman CJ, Vignali DA, Dawson VL, Ko HS, Dawson TM.

Science. 2016 Sep 30;353(6307). pii: aah3374.

PMID:
27708076
6.

DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies.

Funahashi Y, Yoshino Y, Yamazaki K, Mori Y, Mori T, Ozaki Y, Sao T, Ochi S, Iga JI, Ueno SI.

Psychiatry Clin Neurosci. 2017 Jan;71(1):28-35. doi: 10.1111/pcn.12462. Epub 2016 Nov 3.

PMID:
27685250
7.

Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice.

Wu Q, Yang X, Zhang Y, Zhang L, Feng L.

Exp Neurol. 2016 Nov;285(Pt A):61-71. doi: 10.1016/j.expneurol.2016.09.004. Epub 2016 Sep 13.

PMID:
27637804
8.

The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease.

Pavlou MAS, Pinho R, Paiva I, Outeiro TF.

Brain. 2017 Apr 1;140(4):878-886. doi: 10.1093/brain/aww227.

PMID:
27585855
9.

SNCA rs356182 variant increases risk of sporadic Parkinson's disease in ethnic Chinese.

Cheng L, Wang L, Li NN, Yu WJ, Sun XY, Li JY, Zhou D, Peng R.

J Neurol Sci. 2016 Sep 15;368:231-4. doi: 10.1016/j.jns.2016.07.032. Epub 2016 Jul 14.

PMID:
27538639
10.

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure.

Iyer A, Roeters SJ, Schilderink N, Hommersom B, Heeren RM, Woutersen S, Claessens MM, Subramaniam V.

J Biol Chem. 2016 Sep 30;291(40):21110-21122. Epub 2016 Aug 16.

11.

Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.

Mason RJ, Paskins AR, Dalton CF, Smith DP.

Biochemistry. 2016 Aug 30;55(34):4737-41. doi: 10.1021/acs.biochem.6b00708. Epub 2016 Aug 18.

PMID:
27517125
12.

Role of Genomic Instability in Immunotherapy with Checkpoint Inhibitors.

Yaghmour G, Pandey M, Ireland C, Patel K, Nunnery S, Powell D, Baum S, Wiedower E, Schwartzberg LS, Martin MG.

Anticancer Res. 2016 Aug;36(8):4033-8.

PMID:
27466509
13.

Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Alexopoulou Z, Lang J, Perrett RM, Elschami M, Hurry ME, Kim HT, Mazaraki D, Szabo A, Kessler BM, Goldberg AL, Ansorge O, Fulga TA, Tofaris GK.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4688-97. doi: 10.1073/pnas.1523597113. Epub 2016 Jul 21.

14.

The rs3756063 polymorphism is associated with SNCA methylation in the Chinese Han population.

Wei Y, Yang N, Xu Q, Sun Q, Guo J, Li K, Liu Z, Yan X, Zhu X, Tang B.

J Neurol Sci. 2016 Aug 15;367:11-4. doi: 10.1016/j.jns.2016.05.037. Epub 2016 May 19.

PMID:
27423554
15.

The heterozygous A53T mutation in the alpha-synuclein gene in a Chinese Han patient with Parkinson disease: case report and literature review.

Xiong WX, Sun YM, Guan RY, Luo SS, Chen C, An Y, Wang J, Wu JJ.

J Neurol. 2016 Oct;263(10):1984-92. doi: 10.1007/s00415-016-8213-1. Epub 2016 Jul 8. Review.

PMID:
27393118
16.

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation.

Follett J, Bugarcic A, Yang Z, Ariotti N, Norwood SJ, Collins BM, Parton RG, Teasdale RD.

J Biol Chem. 2016 Aug 26;291(35):18283-98. doi: 10.1074/jbc.M115.703157. Epub 2016 Jul 6.

PMID:
27385586
17.

The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation.

Tarutani A, Suzuki G, Shimozawa A, Nonaka T, Akiyama H, Hisanaga S, Hasegawa M.

J Biol Chem. 2016 Sep 2;291(36):18675-88. doi: 10.1074/jbc.M116.734707. Epub 2016 Jul 5.

PMID:
27382062
18.

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway.

Szargel R, Shani V, Abd Elghani F, Mekies LN, Liani E, Rott R, Engelender S.

Hum Mol Genet. 2016 Aug 15;25(16):3476-3490. doi: 10.1093/hmg/ddw189. Epub 2016 Jun 22.

PMID:
27334109
19.

How strong is the evidence that Parkinson's disease is a prion disorder?

Brundin P, Ma J, Kordower JH.

Curr Opin Neurol. 2016 Aug;29(4):459-66. doi: 10.1097/WCO.0000000000000349. Review.

PMID:
27257944
20.

Constitutive translation of human α-synuclein is mediated by the 5'-untranslated region.

Koukouraki P, Doxakis E.

Open Biol. 2016 Apr;6(4):160022. doi: 10.1098/rsob.160022. Epub 2016 Apr 20.

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