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Redox exchange of the disulfides of human two-domain CD4 regulates the conformational dynamics of each domain, providing insight into its mechanisms of control.

Owen GR, Le D, Stoychev S, Cerutti NM, Papathanasopoulos M.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):811-817. doi: 10.1016/j.bbrc.2018.02.161. Epub 2018 Feb 20.


Spontaneous CD4+ and CD8+ T-cell responses directed against cancer testis antigens are present in the peripheral blood of testicular cancer patients.

Pearce H, Hutton P, Chaudhri S, Porfiri E, Patel P, Viney R, Moss P.

Eur J Immunol. 2017 Jul;47(7):1232-1242. doi: 10.1002/eji.201646898. Epub 2017 Jun 26.


Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2.

Owen GR, Channell JA, Forsyth VT, Haertlein M, Mitchell EP, Capovilla A, Papathanasopoulos M, Cerutti NM.

Biochemistry. 2016 Apr 19;55(15):2227-37. doi: 10.1021/acs.biochem.6b00154. Epub 2016 Apr 6.


Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry.

Pham S, Tabarin T, Garvey M, Pade C, Rossy J, Monaghan P, Hyatt A, Böcking T, Leis A, Gaus K, Mak J.

Virology. 2015 Dec;486:121-33. doi: 10.1016/j.virol.2015.09.006. Epub 2015 Sep 30.


The role of CD4 on mechanical properties of live cell membrane.

Bui VC, Nguyen TH.

J Biomed Mater Res A. 2016 Jan;104(1):239-44. doi: 10.1002/jbm.a.35559. Epub 2015 Sep 22.


Phenotypic Correlates of HIV-1 Macrophage Tropism.

Arrildt KT, LaBranche CC, Joseph SB, Dukhovlinova EN, Graham WD, Ping LH, Schnell G, Sturdevant CB, Kincer LP, Mallewa M, Heyderman RS, Rie AV, Cohen MS, Spudich S, Price RW, Montefiori DC, Swanstrom R.

J Virol. 2015 Nov;89(22):11294-311. doi: 10.1128/JVI.00946-15. Epub 2015 Sep 2.


The CD4 C868T Polymorphism and Its Correlation with HIV-1 Infection in a Chinese Population.

Lu Y, Wu J, Qin X, Xie L, Ma L, Huang X, Zhao J, Liu Y, Chen X, Li S.

AIDS Res Hum Retroviruses. 2015 May;31(5):525-30. doi: 10.1089/AID.2014.0303. Epub 2015 Mar 6.


Enhancing the benefits of antiretroviral therapy in Vietnam: towards ending AIDS.

Kato M, Long NH, Duong BD, Nhan do T, Nguyen TT, Hai NH, Giang le M, Hoa do M, Van NT, Suthar AB, Fontaine C, Nadol P, Lo YR, McConnell MS.

Curr HIV/AIDS Rep. 2014 Dec;11(4):487-95. doi: 10.1007/s11904-014-0235-7. Review.


Optimizing ART adherence: update for HIV treatment and prevention.

Robbins RN, Spector AY, Mellins CA, Remien RH.

Curr HIV/AIDS Rep. 2014 Dec;11(4):423-33. doi: 10.1007/s11904-014-0229-5. Review.


Realizing the potential of treatment as prevention: global ART policy and treatment coverage.

Gupta S, Williams B, Montaner J.

Curr HIV/AIDS Rep. 2014 Dec;11(4):479-86. doi: 10.1007/s11904-014-0230-z. Review.


Modeling the implementation of universal coverage for HIV treatment as prevention and its impact on the HIV epidemic.

Ying R, Barnabas RV, Williams BG.

Curr HIV/AIDS Rep. 2014 Dec;11(4):459-67. doi: 10.1007/s11904-014-0232-x. Review.


Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women.

Hirbod T, Kimani J, Tjernlund A, Cheruiyot J, Petrova A, Ball TB, Mugo N, Jaoko W, Plummer FA, Kaul R, Broliden K.

J Immunol. 2013 Oct 1;191(7):3948-54. doi: 10.4049/jimmunol.1301220. Epub 2013 Sep 4.


Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.

Zhang ZR, Bonifacino JS, Hegde RS.

Cell. 2013 Aug 1;154(3):609-22. doi: 10.1016/j.cell.2013.06.038. Epub 2013 Jul 25.


Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases.

Tseng WY, Huang YS, Chiang NY, Chou YP, Wu YJ, Luo SF, Kuo CF, Lin KM, Lin HH.

PLoS One. 2013 May 21;8(5):e63963. doi: 10.1371/journal.pone.0063963. Print 2013.


Control of inflammatory heart disease by CD4+ T cells.

Barin JG, Čiháková D.

Ann N Y Acad Sci. 2013 May;1285:80-96. doi: 10.1111/nyas.12134. Review.


Intrinsic impairment of CD4(+)CD25(+) regulatory T cells in acquired aplastic anemia.

Shi J, Ge M, Lu S, Li X, Shao Y, Huang J, Huang Z, Zhang J, Nie N, Zheng Y.

Blood. 2012 Aug 23;120(8):1624-32. doi: 10.1182/blood-2011-11-390708. Epub 2012 Jul 13.


Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis.

Adekambi T, Ibegbu CC, Kalokhe AS, Yu T, Ray SM, Rengarajan J.

PLoS One. 2012;7(4):e36046. doi: 10.1371/journal.pone.0036046. Epub 2012 Apr 24.


HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome.

Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, Ranasinghe S, Lindqvist M, Davis I, Lane K, Rychert J, Rosenberg ES, Piechocka-Trocha A, Brass AL, Brenchley JM, Walker BD, Streeck H.

Sci Transl Med. 2012 Feb 29;4(123):123ra25. doi: 10.1126/scitranslmed.3003165.


The impact of early CD4+ lymphocyte recovery on the outcome of patients who undergo allogeneic bone marrow or peripheral blood stem cell transplantation.

Fedele R, Martino M, Garreffa C, Messina G, Console G, Princi D, Dattola A, Moscato T, Massara E, Spiniello E, Irrera G, Iacopino P.

Blood Transfus. 2012 Apr;10(2):174-80. doi: 10.2450/2012.0034-11. Epub 2012 Jan 24.


Incidence of tuberculosis in HIV-infected patients receiving HAART: interaction between TST and CD4 count.

Martín-Echevarria E, Rodríguez-Zapata M, Torralba M, Fernández JM, Moreno A, Casado JL, Dronda F, Pérez-Elías MJ, Navas E, Moreno S.

Int J Tuberc Lung Dis. 2011 Oct;15(10):1347-52. doi: 10.5588/ijtld.10.0686.


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