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Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.

Robertson N, Rappas M, Doré AS, Brown J, Bottegoni G, Koglin M, Cansfield J, Jazayeri A, Cooke RM, Marshall FH.

Nature. 2018 Jan 3;553(7686):111-114. doi: 10.1038/nature25025.


C5aR contributes to the weak Th1 profile induced by an outbreak strain of Mycobacterium tuberculosis.

Sabio Y García CA, Yokobori N, Basile JI, Balboa L, González A, López B, Ritacco V, Barrera S, Sasiain MD.

Tuberculosis (Edinb). 2017 Mar;103:16-23. doi: 10.1016/ Epub 2016 Dec 21.


Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton-Valentine Leucocidin and γ-Hemolysin.

Zimmermann-Meisse G, Prévost G, Jover E.

Toxins (Basel). 2017 Jan 20;9(1). pii: E41. doi: 10.3390/toxins9010041.


Expression of the anaphylatoxin C5a receptor in gastric cancer: implications for vascular invasion and patient outcomes.

Nitta H, Shimose T, Emi Y, Imamura T, Ohnishi K, Kusumoto T, Yamamoto M, Fukuzawa K, Takahashi I, Higashi H, Tsuji A, Akagi Y, Oki E, Maehara Y, Baba H; Kyushu Study Group of Clinical Cancer (KSCC) ancillary study.

Med Oncol. 2016 Nov;33(11):118. doi: 10.1007/s12032-016-0834-9. Epub 2016 Sep 29.


Nerve Growth Factor Secretion From Pulp Fibroblasts is Modulated by Complement C5a Receptor and Implied in Neurite Outgrowth.

Chmilewsky F, Ayaz W, Appiah J, About I, Chung SH.

Sci Rep. 2016 Aug 19;6:31799. doi: 10.1038/srep31799.


Influence of the C5a-C5a receptor system on breast cancer progression and patient prognosis.

Imamura T, Yamamoto-Ibusuki M, Sueta A, Kubo T, Irie A, Kikuchi K, Kariu T, Iwase H.

Breast Cancer. 2016 Nov;23(6):876-885. Epub 2015 Oct 22.


C5a receptor enhances hepatocellular carcinoma cell invasiveness via activating ERK1/2-mediated epithelial-mesenchymal transition.

Hu WH, Hu Z, Shen X, Dong LY, Zhou WZ, Yu XX.

Exp Mol Pathol. 2016 Feb;100(1):101-8. doi: 10.1016/j.yexmp.2015.10.001. Epub 2015 Oct 22.


Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development.

Quadrini KJ, Hegelund AC, Cortes KE, Xue C, Kennelly SM, Ji H, Högerkorp CM, Mc Closkey TW.

Cytometry B Clin Cytom. 2016 Mar;90(2):177-90. doi: 10.1002/cyto.b.21260. Epub 2015 Sep 17.


C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus.

Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon T, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ.

Immunology. 2015 Sep;146(1):130-43. doi: 10.1111/imm.12489. Epub 2015 Jul 15.


Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.

Zheng YY, Xie X, Ma YT, Yang YN, Fu ZY, Li XM, Pan S, Adi D, Chen BD, Liu F.

Diagn Pathol. 2015 Apr 18;10:33. doi: 10.1186/s13000-015-0261-9.


C5aR is frequently expressed in metastatic renal cell carcinoma and plays a crucial role in cell invasion via the ERK and PI3 kinase pathways.

Maeda Y, Kawano Y, Wada Y, Yatsuda J, Motoshima T, Murakami Y, Kikuchi K, Imamura T, Eto M.

Oncol Rep. 2015 Apr;33(4):1844-50. doi: 10.3892/or.2015.3800. Epub 2015 Feb 13.


Complement C5a receptor gene 450 C/T polymorphism in renal transplant recipients: association of the CT genotype with graft outcome.

Günesacar R, Opelz G, Erken E, Döhler B, Ruhenstroth A, Süsal C.

Tissue Antigens. 2015 Feb;85(2):104-7. doi: 10.1111/tan.12495. Epub 2015 Jan 13.


Influence of component 5a receptor 1 (C5AR1) -1330T/G polymorphism on nonsedating H1-antihistamines therapy in Chinese patients with chronic spontaneous urticaria.

Yan S, Chen W, Wen S, Zhu W, Guo A, Chen X, Zhang C, Chen M, Zhang J, Su J, Zhao Y, He Y, Liu Z, Zhou H, Zeng W, Li J, Chen X.

J Dermatol Sci. 2014 Dec;76(3):240-5. doi: 10.1016/j.jdermsci.2014.09.012. Epub 2014 Oct 8.


Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor.

van den Berg CW, Tambourgi DV, Clark HW, Hoong SJ, Spiller OB, McGreal EP.

J Immunol. 2014 Feb 15;192(4):1787-95. doi: 10.4049/jimmunol.1301920. Epub 2014 Jan 20.


Modulation of retinal Müller cells by complement receptor C5aR.

Cheng L, Bu H, Portillo JA, Li Y, Subauste CS, Huang SS, Kern TS, Lin F.

Invest Ophthalmol Vis Sci. 2013 Dec 17;54(13):8191-8. doi: 10.1167/iovs.13-12428.


Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

Seow V, Lim J, Iyer A, Suen JY, Ariffin JK, Hohenhaus DM, Sweet MJ, Fairlie DP.

J Immunol. 2013 Oct 15;191(8):4308-16. doi: 10.4049/jimmunol.1301355. Epub 2013 Sep 16.


Overexpression of CD88 predicts poor prognosis in non-small-cell lung cancer.

Gu J, Ding JY, Lu CL, Lin ZW, Chu YW, Zhao GY, Guo J, Ge D.

Lung Cancer. 2013 Aug;81(2):259-65. doi: 10.1016/j.lungcan.2013.04.020. Epub 2013 May 23.


The staphylococcal toxin Panton-Valentine Leukocidin targets human C5a receptors.

Spaan AN, Henry T, van Rooijen WJM, Perret M, Badiou C, Aerts PC, Kemmink J, de Haas CJC, van Kessel KPM, Vandenesch F, Lina G, van Strijp JAG.

Cell Host Microbe. 2013 May 15;13(5):584-594. doi: 10.1016/j.chom.2013.04.006.


Changes and regulation of the C5a receptor on neutrophils during septic shock in humans.

Unnewehr H, Rittirsch D, Sarma JV, Zetoune F, Flierl MA, Perl M, Denk S, Weiss M, Schneider ME, Monk PN, Neff T, Mihlan M, Barth H, Gebhard F, Ward PA, Huber-Lang M.

J Immunol. 2013 Apr 15;190(8):4215-25. doi: 10.4049/jimmunol.1200534. Epub 2013 Mar 11.


The alternative C5a receptor function.

Nishiura H.

Adv Exp Med Biol. 2013;735:111-21. Review.


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