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Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model.

Hou JX, Cheng SS, Chen L, Wang QH, Shi Y, Xu Y, Yin ZY, Chen GQ.

CNS Neurosci Ther. 2016 Mar;22(3):244-7. doi: 10.1111/cns.12509. Epub 2016 Jan 25. No abstract available.


Synaptic function of nicastrin in hippocampal neurons.

Lee SH, Sharma M, Südhof TC, Shen J.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8973-8. doi: 10.1073/pnas.1408554111. Epub 2014 Jun 2.


Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.

Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.

Neurobiol Dis. 2007 Feb;25(2):291-6. Epub 2006 Oct 27.


Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.

Nguyen V, Hawkins C, Bergeron C, Supala A, Huang J, Westaway D, St George-Hyslop P, Rozmahel R.

Brain Res. 2006 May 1;1086(1):76-84. Epub 2006 Apr 13.


Nicastrin functions as a gamma-secretase-substrate receptor.

Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Südhof T, Yu G.

Cell. 2005 Aug 12;122(3):435-47.


gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.

Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B.

J Cell Sci. 2003 Mar 15;116(Pt 6):1127-36.


Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.

Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME.

Sci Rep. 2015 Nov 26;5:17042. doi: 10.1038/srep17042.


A new tumor suppressor role for the Notch pathway in bladder cancer.

Rampias T, Vgenopoulou P, Avgeris M, Polyzos A, Stravodimos K, Valavanis C, Scorilas A, Klinakis A.

Nat Med. 2014 Oct;20(10):1199-205. doi: 10.1038/nm.3678. Epub 2014 Sep 7.


Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.

Sesele K, Thanopoulou K, Paouri E, Tsefou E, Klinakis A, Georgopoulos S.

Aging Cell. 2013 Dec;12(6):1032-40. doi: 10.1111/acel.12131. Epub 2013 Aug 11.


Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.

Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H.

J Biol Chem. 2011 Sep 9;286(36):31153-8. doi: 10.1074/jbc.C111.235267. Epub 2011 Jul 18.


Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B.

J Biol Chem. 2008 Jul 18;283(29):20096-105. doi: 10.1074/jbc.M803040200. Epub 2008 May 23.


Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.

Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB.

Neurosci Lett. 2007 Dec 18;429(2-3):95-100. Epub 2007 Oct 13.


Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase.

Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC.

J Biol Chem. 2007 Nov 2;282(44):32264-73. Epub 2007 Sep 7.


Neprilysin activity and expression are controlled by nicastrin.

Pardossi-Piquard R, Dunys J, Yu G, St George-Hyslop P, Alves da Costa C, Checler F.

J Neurochem. 2006 May;97(4):1052-6. Epub 2006 Apr 5.


Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.

Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.

Biochemistry. 2004 Mar 30;43(12):3555-63.


The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.

Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG.

Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12.


Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment.

Mao G, Cui MZ, Li T, Jin Y, Xu X.

J Neurochem. 2012 Dec;123(5):837-44. doi: 10.1111/jnc.12016. Epub 2012 Oct 11.

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