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Items: 1 to 20 of 1097


RAC1 expression and role in IL-1β production and oxidative stress generation in familial Mediterranean fever (FMF) patients.

Ibrahim JN, Jounblat R, Jalkh N, Abou Ghoch J, Al Hageh C, Chouery E, Mégarbané A, Lecron JC, Medlej-Hashim M.

Eur Cytokine Netw. 2018 Nov 1;29(4):127-135. doi: 10.1684/ecn.2018.0416.


Downregulated Rac1 promotes apoptosis and inhibits the clearance of apoptotic cells in airway epithelial cells, which may be associated with airway hyper-responsiveness in asthma.

Wan J, Cao Y, Abdelaziz MH, Huang L, Kesavan DK, Su Z, Wang S, Xu H.

Scand J Immunol. 2019 May;89(5):e12752. doi: 10.1111/sji.12752. Epub 2019 Mar 5.


High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture.

Marston DJ, Anderson KL, Swift MF, Rougie M, Page C, Hahn KM, Volkmann N, Hanein D.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1267-1272. doi: 10.1073/pnas.1808830116. Epub 2019 Jan 10.


Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation.

Ye YP, Jiao HL, Wang SY, Xiao ZY, Zhang D, Qiu JF, Zhang LJ, Zhao YL, Li TT, Li-Liang, Liao WT, Ding YQ.

J Exp Clin Cancer Res. 2018 Dec 4;37(1):299. doi: 10.1186/s13046-018-0958-1.


Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.

Cardama GA, Alonso DF, Gonzalez N, Maggio J, Gomez DE, Rolfo C, Menna PL.

Crit Rev Oncol Hematol. 2018 Apr;124:29-36. doi: 10.1016/j.critrevonc.2018.01.012. Epub 2018 Feb 4. Review.


Rac1 is a novel therapeutic target in mantle cell lymphoma.

Tian T, Bi C, Hein AL, Zhang X, Wang C, Shen S, Yuan J, Greiner TC, Enke C, Vose J, Yan Y, Fu K.

Blood Cancer J. 2018 Feb 12;8(2):17. doi: 10.1038/s41408-018-0052-0. No abstract available.


Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role.

Kovacs-Kasa A, Kim KM, Cherian-Shaw M, Black SM, Fulton DJ, Verin AD.

J Cell Physiol. 2018 Aug;233(8):5736-5746. doi: 10.1002/jcp.26281. Epub 2018 Mar 7.


High expression of Rac1 is correlated with partial reversed cell polarity and poor prognosis in invasive ductal carcinoma of the breast.

Liu B, Xiong J, Liu G, Wu J, Wen L, Zhang Q, Zhang C.

Tumour Biol. 2017 Jul;39(7):1010428317710908. doi: 10.1177/1010428317710908.


Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.

Yoon C, Cho SJ, Chang KK, Park DJ, Ryeom SW, Yoon SS.

Mol Cancer Res. 2017 Aug;15(8):1106-1116. doi: 10.1158/1541-7786.MCR-17-0053. Epub 2017 May 1.


Association analysis of RAC1 single nucleotide polymorphisms with ulcerative colitis.

Taher M, Ebrahimi Daryani N, Hedayat M, Eslamian M, Farhadi E, Mahmoudi M, Shirzad S, Nouri Taromlou MK, Chaharmahali M, Nicknam MH, Bashashati M, Rezaei N.

Clin Res Hepatol Gastroenterol. 2017 Sep;41(4):487-489. doi: 10.1016/j.clinre.2017.03.002. Epub 2017 Apr 12. No abstract available.


Emerging roles of RAC1 in treating lung cancer patients.

Zou T, Mao X, Yin J, Li X, Chen J, Zhu T, Li Q, Zhou H, Liu Z.

Clin Genet. 2017 Apr;91(4):520-528. doi: 10.1111/cge.12908. Epub 2016 Nov 24. Review.


Impact of point mutation P29S in RAC1 on tumorigenesis.

Rajendran V, Gopalakrishnan C, Purohit R.

Tumour Biol. 2016 Nov;37(11):15293-15304. Epub 2016 Oct 3.


Rac-ing from Epithelial Secretor to Eater.

Naylor MJ.

Dev Cell. 2016 Sep 12;38(5):450-1. doi: 10.1016/j.devcel.2016.08.016.


Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.

Marei H, Malliri A.

Small GTPases. 2017 Jul 3;8(3):139-163. doi: 10.1080/21541248.2016.1211398. Epub 2016 Jul 21. Review.


Growth arrest of lung carcinoma cells (A549) by polyacrylate-anchored peroxovanadate by activating Rac1-NADPH oxidase signalling axis.

Chatterjee N, Anwar T, Islam NS, Ramasarma T, Ramakrishna G.

Mol Cell Biochem. 2016 Sep;420(1-2):9-20. doi: 10.1007/s11010-016-2761-7. Epub 2016 Jul 19. Erratum in: Mol Cell Biochem. 2016 Oct 28;:.


Quantification of Rac1 and Rac1b in serum of non small cell lung cancer by label free real time assay.

Sahu V, Gupta A, Kumar R, Gupta T, Mohan A, Dey S.

Clin Chim Acta. 2016 Sep 1;460:231-5. doi: 10.1016/j.cca.2016.07.009. Epub 2016 Jul 15.


Rho GTPases: RAC1 polymorphisms affected platinum-based chemotherapy toxicity in lung cancer patients.

Zou T, Yin J, Zheng W, Xiao L, Tan L, Chen J, Wang Y, Li X, Qian C, Cui J, Zhang W, Zhou H, Liu Z.

Cancer Chemother Pharmacol. 2016 Aug;78(2):249-58. doi: 10.1007/s00280-016-3072-0. Epub 2016 Jun 14.


RAC1 activation drives pathologic interactions between the epidermis and immune cells.

Winge MC, Ohyama B, Dey CN, Boxer LM, Li W, Ehsani-Chimeh N, Truong AK, Wu D, Armstrong AW, Makino T, Davidson M, Starcevic D, Kislat A, Nguyen NT, Hashimoto T, Homey B, Khavari PA, Bradley M, Waterman EA, Marinkovich MP.

J Clin Invest. 2016 Jul 1;126(7):2661-77. doi: 10.1172/JCI85738. Epub 2016 Jun 13.


Thiopurine Prodrugs Mediate Immunosuppressive Effects by Interfering with Rac1 Protein Function.

Shin JY, Wey M, Umutesi HG, Sun X, Simecka J, Heo J.

J Biol Chem. 2016 Jun 24;291(26):13699-714. doi: 10.1074/jbc.M115.694422. Epub 2016 May 9.

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