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MicroRNA-526a targets p21-activated kinase 7 to inhibit tumorigenesis in hepatocellular carcinoma.

Zhan L, Pan Y, Chen L, Chen Z, Zhang H, Sun C.

Mol Med Rep. 2017 Jul;16(1):837-844. doi: 10.3892/mmr.2017.6658. Epub 2017 May 31.


High-level expression of P21-Cdc/Rac-activated kinase 7 is closely related to metastatic potential and poor prognosis of colon carcinoma.

Li C, Chen J, Wang Y, Song G, Xiao C, Yan D, Zhong L, Sun X, Wang X, Yu F, Yu Y, Tang H, Peng Z.

Oncotarget. 2016 Jul 19;7(29):46042-46055. doi: 10.18632/oncotarget.10017. Erratum in: Oncotarget. 2017 Jul 4;8(27):45031.


PAK5 is auto-activated by a central domain that promotes kinase oligomerization.

Tabanifar B, Zhao Z, Manser E.

Biochem J. 2016 Jun 15;473(12):1777-89. doi: 10.1042/BCJ20160132. Epub 2016 Apr 19.


Over expression of p21-activated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers.

He S, Liu M, Zhang W, Xu N, Zhu H.

Cancer Biomark. 2016;16(2):203-9. doi: 10.3233/CBM-150557.


Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5.

Gu X, Wang C, Wang X, Ma G, Li Y, Cui L, Chen Y, Zhao B, Li K.

Int J Biol Sci. 2015 Jan 12;11(2):230-7. doi: 10.7150/ijbs.9193. eCollection 2015.


p21-activated kinase 7 is an oncogene in human osteosarcoma.

Han K, Zhou Y, Gan ZH, Qi WX, Zhang JJ, Fen T, Meng W, Jiang L, Shen Z, Min DL.

Cell Biol Int. 2014 Dec;38(12):1394-402. doi: 10.1002/cbin.10351. Epub 2014 Aug 6.


An oncogenic kinase: putting PAK5 forward.

Wen YY, Zheng JN, Pei DS.

Expert Opin Ther Targets. 2014 Jul;18(7):807-15. doi: 10.1517/14728222.2014.918103. Epub 2014 May 29. Review.


Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway.

Han ZX, Wang XX, Zhang SN, Wu JX, Qian HY, Wen YY, Tian H, Pei DS, Zheng JN.

Brain Tumor Pathol. 2014 Oct;31(4):234-41. doi: 10.1007/s10014-013-0161-1. Epub 2013 Sep 6.


The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer.

Li D, Yao X, Zhang P.

Mol Cell Biochem. 2013 Nov;383(1-2):191-9. doi: 10.1007/s11010-013-1767-7. Epub 2013 Jul 23.


A role for p21-activated kinase 7 in the development of gastric cancer.

Gu J, Li K, Li M, Wu X, Zhang L, Ding Q, Wu W, Yang J, Mu J, Wen H, Ding Q, Lu J, Hao Y, Chen L, Zhang W, Li S, Liu Y.

FEBS J. 2013 Jan;280(1):46-55. doi: 10.1111/febs.12048. Epub 2012 Nov 23.


P21-activated kinase 5 is overexpressed during colorectal cancer progression and regulates colorectal carcinoma cell adhesion and migration.

Gong W, An Z, Wang Y, Pan X, Fang W, Jiang B, Zhang H.

Int J Cancer. 2009 Aug 1;125(3):548-55. doi: 10.1002/ijc.24428.


Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties.

Cotteret S, Chernoff J.

Mol Cell Biol. 2006 Apr;26(8):3215-30.


PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.

Matenia D, Griesshaber B, Li XY, Thiessen A, Johne C, Jiao J, Mandelkow E, Mandelkow EM.

Mol Biol Cell. 2005 Sep;16(9):4410-22. Epub 2005 Jul 12.


A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization.

Cau J, Faure S, Comps M, Delsert C, Morin N.

J Cell Biol. 2001 Dec 10;155(6):1029-42.


MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5.

Pan YJ, Wei LL, Wu XJ, Huo FC, Mou J, Pei DS.

Cell Death Dis. 2017 Oct 26;8(10):e3155. doi: 10.1038/cddis.2017.561.


PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo.

Zhang YC, Huo FC, Wei LL, Gong CC, Pan YJ, Mou J, Pei DS.

J Exp Clin Cancer Res. 2017 Oct 17;36(1):146. doi: 10.1186/s13046-017-0610-5.


MicroRNA-492 overexpression exerts suppressive effects on the progression of osteosarcoma by targeting PAK7.

Song X, Xie Y, Liu Y, Shao M, Yang W.

Int J Mol Med. 2017 Sep;40(3):891-897. doi: 10.3892/ijmm.2017.3046. Epub 2017 Jun 29.


PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells.

Ismail AF, Oskay Halacli S, Babteen N, De Piano M, Martin TA, Jiang WG, Khan MS, Dasgupta P, Wells CM.

Biochem J. 2017 Mar 24;474(8):1333-1346. doi: 10.1042/BCJ20160875.


miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma.

Zhai J, Qu S, Li X, Zhong J, Chen X, Qu Z, Wu D.

Biochem Biophys Res Commun. 2015 Aug 14;464(1):161-7. doi: 10.1016/j.bbrc.2015.06.108. Epub 2015 Jun 23.


P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression.

He S, Feng M, Liu M, Yang S, Yan S, Zhang W, Wang Z, Hu C, Xu Q, Chen L, Zhu H, Xu N.

PLoS One. 2014 Dec 1;9(12):e113989. doi: 10.1371/journal.pone.0113989. eCollection 2014.

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