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L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells.

Wang R, Jiao H, Zhao J, Wang X, Lin H.

Oxid Med Cell Longev. 2018 Apr 26;2018:7569127. doi: 10.1155/2018/7569127. eCollection 2018.


Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.

Guo J, Zhang T, Guo Y, Sun T, Li H, Zhang X, Yin H, Cao G, Yin Y, Wang H, Shi L, Guo X, Sha J, Eppig JJ, Su YQ.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5326-E5333. doi: 10.1073/pnas.1800352115. Epub 2018 May 21.


Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease.

Caccamo A, Belfiore R, Oddo S.

Neurobiol Aging. 2018 Aug;68:59-67. doi: 10.1016/j.neurobiolaging.2018.03.032. Epub 2018 Apr 5.


Locally translated mTOR controls axonal local translation in nerve injury.

Terenzio M, Koley S, Samra N, Rishal I, Zhao Q, Sahoo PK, Urisman A, Marvaldi L, Oses-Prieto JA, Forester C, Gomes C, Kalinski AL, Di Pizio A, Doron-Mandel E, Perry RB, Koppel I, Twiss JL, Burlingame AL, Fainzilber M.

Science. 2018 Mar 23;359(6382):1416-1421. doi: 10.1126/science.aan1053.


High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress.

Lei J, Zhao L, Zhang Y, Wu Y, Liu Y.

Cell Physiol Biochem. 2018;45(6):2431-2443. doi: 10.1159/000488231. Epub 2018 Mar 15.


Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation.

Tsuji-Tamura K, Ogawa M.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):326-331. doi: 10.1016/j.bbrc.2018.02.080. Epub 2018 Feb 8.


Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells.

Cong XX, Rao XS, Lin JX, Liu XC, Zhang GA, Gao XK, He MY, Shen WL, Fan W, Pioletti D, Zheng LL, Liu HH, Yin Z, Low BC, Schweitzer R, Ouyang H, Chen X, Zhou YT.

Stem Cells. 2018 Apr;36(4):527-539. doi: 10.1002/stem.2765. Epub 2018 Jan 5.


mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein.

Nofal M, Zhang K, Han S, Rabinowitz JD.

Mol Cell. 2017 Sep 21;67(6):936-946.e5. doi: 10.1016/j.molcel.2017.08.011. Epub 2017 Sep 14.


The endotoxemia cardiac dysfunction is attenuated by AMPK/mTOR signaling pathway regulating autophagy.

Zhang J, Zhao P, Quan N, Wang L, Chen X, Cates C, Rousselle T, Li J.

Biochem Biophys Res Commun. 2017 Oct 21;492(3):520-527. doi: 10.1016/j.bbrc.2017.08.034. Epub 2017 Aug 12.


Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

Karmaus PWF, Herrada AA, Guy C, Neale G, Dhungana Y, Long L, Vogel P, Avila J, Clish CB, Chi H.

J Exp Med. 2017 Sep 4;214(9):2629-2647. doi: 10.1084/jem.20161855. Epub 2017 Aug 7.


Ginkgo biloba exocarp extracts induces autophagy in Lewis lung cancer cells involving AMPK / mTOR / p70S6k signaling pathway.

Cao C, Han D, Su Y, Ge Y, Chen H, Xu A.

Biomed Pharmacother. 2017 Sep;93:1128-1135. doi: 10.1016/j.biopha.2017.07.036. Epub 2017 Jul 19.


mTOR signaling pathway differently regulates central and peripheral axon regeneration.

Huang Z, Wang W, Ma J, Li B, Chen J, Yang H, Saijilafu.

Acta Biochim Biophys Sin (Shanghai). 2017 Aug 1;49(8):689-695. doi: 10.1093/abbs/gmx068.


MTOR controls genesis and autophagy of GABAergic interneurons during brain development.

Ka M, Smith AL, Kim WY.

Autophagy. 2017 Aug 3;13(8):1348-1363. doi: 10.1080/15548627.2017.1327927. Epub 2017 Jun 9.


Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels.

Takahashi K, Yanai S, Shimokado K, Ishigami A.

Nutrition. 2017 Jun;38:1-8. doi: 10.1016/j.nut.2016.12.021. Epub 2017 Jan 7.


Endothelial deletion of mTORC1 protects against hindlimb ischemia in diabetic mice via activation of autophagy, attenuation of oxidative stress and alleviation of inflammation.

Fan W, Han D, Sun Z, Ma S, Gao L, Chen J, Li X, Li X, Fan M, Li C, Hu D, Wang Y, Cao F.

Free Radic Biol Med. 2017 Jul;108:725-740. doi: 10.1016/j.freeradbiomed.2017.05.001. Epub 2017 May 1.


Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling.

Wallin DJ, Zamora TG, Alexander M, Ennis KM, Tran PV, Georgieff MK.

Pediatr Res. 2017 Sep;82(3):501-508. doi: 10.1038/pr.2017.88. Epub 2017 May 31.


Cell-autonomous requirement for mammalian target of rapamycin (Mtor) in spermatogonial proliferation and differentiation in the mouseā€ .

Serra ND, Velte EK, Niedenberger BA, Kirsanov O, Geyer CB.

Biol Reprod. 2017 Apr 1;96(4):816-828. doi: 10.1093/biolre/iox022.


The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury.

Zhang C, Wang S, Li J, Zhang W, Zheng L, Yang C, Zhu T, Rong R.

Cell Death Dis. 2017 Mar 23;8(3):e2695. doi: 10.1038/cddis.2017.86.


Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.

Li G, Qin L, Wang L, Li X, Caulk AW, Zhang J, Chen PY, Xin S.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1110-H1119. doi: 10.1152/ajpheart.00677.2016. Epub 2017 Feb 17.


mTOR/autophagy pathway in the hippocampus of rats suffering intermittent hypoxia preconditioning and global cerebral ischemia-reperfusion.

Zhao YN, Guo XF, Li JM, Chen CX, Li SX, Xu CJ.

Oncotarget. 2017 Apr 4;8(14):23353-23359. doi: 10.18632/oncotarget.15058.

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