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Urinary bladder hypertrophy characteristic of male ROMK Bartter's mice does not occur in female mice.

Kim JM, Xu S, Guo X, Hu H, Dong K, Wang T.

Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R334-R341. doi: 10.1152/ajpregu.00315.2017. Epub 2017 Nov 1.


Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.

Dong K, Yan Q, Lu M, Wan L, Hu H, Guo J, Boulpaep E, Wang W, Giebisch G, Hebert SC, Wang T.

J Biol Chem. 2016 Mar 4;291(10):5259-69. doi: 10.1074/jbc.M115.707877. Epub 2016 Jan 4.


Lovastatin-Induced Phosphatidylinositol-4-Phosphate 5-Kinase Diffusion from Microvilli Stimulates ROMK Channels.

Liu BC, Yang LL, Lu XY, Song X, Li XC, Chen G, Li Y, Yao X, Humphrey DR, Eaton DC, Shen BZ, Ma HP.

J Am Soc Nephrol. 2015 Jul;26(7):1576-87. doi: 10.1681/ASN.2013121326. Epub 2014 Oct 27.


Differential regulation of ROMK (Kir1.1) in distal nephron segments by dietary potassium.

Wade JB, Fang L, Coleman RA, Liu J, Grimm PR, Wang T, Welling PA.

Am J Physiol Renal Physiol. 2011 Jun;300(6):F1385-93. doi: 10.1152/ajprenal.00592.2010. Epub 2011 Mar 30.


Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.

Fang L, Li D, Welling PA.

Am J Physiol Renal Physiol. 2010 Dec;299(6):F1359-64. doi: 10.1152/ajprenal.00257.2010. Epub 2010 Oct 6.


Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds.

Dvoryanchikov G, Sinclair MS, Perea-Martinez I, Wang T, Chaudhari N.

J Comp Neurol. 2009 Nov 1;517(1):1-14. doi: 10.1002/cne.22152.


Effects of mineralocorticoid and K+ concentration on K+ secretion and ROMK channel expression in a mouse cortical collecting duct cell line.

Fodstad H, Gonzalez-Rodriguez E, Bron S, Gaeggeler H, Guisan B, Rossier BC, Horisberger JD.

Am J Physiol Renal Physiol. 2009 May;296(5):F966-75. doi: 10.1152/ajprenal.90475.2008. Epub 2009 Mar 18.


Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production.

Yan Q, Yang X, Cantone A, Giebisch G, Hebert S, Wang T.

Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R997-R1004. doi: 10.1152/ajpregu.00051.2007. Epub 2008 Jun 25.


Mouse model of type II Bartter's syndrome. I. Upregulation of thiazide-sensitive Na-Cl cotransport activity.

Cantone A, Yang X, Yan Q, Giebisch G, Hebert SC, Wang T.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1366-72. doi: 10.1152/ajprenal.00608.2007. Epub 2008 Apr 2.


Mouse model of type II Bartter's syndrome. II. Altered expression of renal sodium- and water-transporting proteins.

Wagner CA, Loffing-Cueni D, Yan Q, Schulz N, Fakitsas P, Carrel M, Wang T, Verrey F, Geibel JP, Giebisch G, Hebert SC, Loffing J.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1373-80. doi: 10.1152/ajprenal.00613.2007. Epub 2008 Mar 5.


Maxi-K channels contribute to urinary potassium excretion in the ROMK-deficient mouse model of Type II Bartter's syndrome and in adaptation to a high-K diet.

Bailey MA, Cantone A, Yan Q, MacGregor GG, Leng Q, Amorim JB, Wang T, Hebert SC, Giebisch G, Malnic G.

Kidney Int. 2006 Jul;70(1):51-9. Epub 2006 May 17.


Regulation of ROMK (Kir1.1) channels: new mechanisms and aspects.

Wang WH.

Am J Physiol Renal Physiol. 2006 Jan;290(1):F14-9. Review.


ROMK is required for expression of the 70-pS K channel in the thick ascending limb.

Lu M, Wang T, Yan Q, Wang W, Giebisch G, Hebert SC.

Am J Physiol Renal Physiol. 2004 Mar;286(3):F490-5. Epub 2003 Nov 4.


Na+/H+ exchange regulatory factor 1 is required for ROMK1 K+ channel expression in the surface membrane of cultured M-1 cortical collecting duct cells.

Suzuki T, Nakamura K, Mayanagi T, Sobue K, Kubokawa M.

Biochem Biophys Res Commun. 2017 Jul 22;489(2):116-122. doi: 10.1016/j.bbrc.2017.05.104. Epub 2017 May 19.


ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.

Murthy M, Kurz T, O'Shaughnessy KM.

Physiol Rep. 2016 Jul;4(13). pii: e12850. doi: 10.14814/phy2.12850.


K restriction inhibits protein phosphatase 2B (PP2B) and suppression of PP2B decreases ROMK channel activity in the CCD.

Zhang Y, Lin DH, Wang ZJ, Jin Y, Yang B, Wang WH.

Am J Physiol Cell Physiol. 2008 Mar;294(3):C765-73. doi: 10.1152/ajpcell.00528.2007. Epub 2008 Jan 9.


Regulation of ROMK (Kir 1.1) channel expression in kidney thick ascending limb by hypertonicity: role of TonEBP and MAPK pathways.

Gallazzini M, Karim Z, Bichara M.

Nephron Physiol. 2006;104(4):126-35. Epub 2006 Sep 22.


Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.

Yamauchi K, Yang SS, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2005 Jul 8;332(3):750-5.


Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice.

Lu M, Wang T, Yan Q, Yang X, Dong K, Knepper MA, Wang W, Giebisch G, Shull GE, Hebert SC.

J Biol Chem. 2002 Oct 4;277(40):37881-7. Epub 2002 Jul 18.


Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.

Lorenz JN, Baird NR, Judd LM, Noonan WT, Andringa A, Doetschman T, Manning PA, Liu LH, Miller ML, Shull GE.

J Biol Chem. 2002 Oct 4;277(40):37871-80. Epub 2002 Jul 16.

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