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Items: 1 to 20 of 23

1.

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ.

J Gen Physiol. 2016 Jun;147(6):497-505. doi: 10.1085/jgp.201611601.

2.

The isoforms generated by alternative translation initiation adopt similar conformation in the selectivity filter in TREK-2.

Zhuo RG, Peng P, Liu XY, Zhang SZ, Xu JP, Zheng JQ, Wei XL, Ma XY.

J Physiol Biochem. 2015 Dec;71(4):601-10. doi: 10.1007/s13105-015-0422-z. Epub 2015 Aug 14.

PMID:
26271386
3.

Insights into the stimulatory mechanism of 2-aminoethoxydiphenyl borate on TREK-2 potassium channel.

Zhuo RG, Liu XY, Zhang SZ, Wei XL, Zheng JQ, Xu JP, Ma XY.

Neuroscience. 2015 Aug 6;300:85-93. doi: 10.1016/j.neuroscience.2015.05.012. Epub 2015 May 14.

PMID:
25982558
4.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP.

Science. 2015 Mar 13;347(6227):1256-9. doi: 10.1126/science.1261512.

5.

Alternative splicing determines mRNA translation initiation and function of human K(2P)10.1 K+ channels.

Staudacher K, Baldea I, Kisselbach J, Staudacher I, Rahm AK, Schweizer PA, Becker R, Katus HA, Thomas D.

J Physiol. 2011 Aug 1;589(Pt 15):3709-20. doi: 10.1113/jphysiol.2011.210666. Epub 2011 Jun 13.

6.
8.

The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels.

Zhuo RG, Peng P, Zheng JQ, Zhang YL, Wen L, Wei XL, Ma XY.

Biochem Biophys Res Commun. 2017 Aug 26;490(3):1125-1131. doi: 10.1016/j.bbrc.2017.06.200. Epub 2017 Jul 1.

PMID:
28676394
9.

Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

Kisselbach J, Seyler C, Schweizer PA, Gerstberger R, Becker R, Katus HA, Thomas D.

Br J Pharmacol. 2014 Dec;171(23):5182-94. doi: 10.1111/bph.12596. Epub 2014 Aug 28.

10.

Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.

Innamaa A, Jackson L, Asher V, van Schalkwyk G, Warren A, Keightley A, Hay D, Bali A, Sowter H, Khan R.

Clin Transl Oncol. 2013 Nov;15(11):910-8. doi: 10.1007/s12094-013-1022-4. Epub 2013 Mar 12.

PMID:
23479219
11.

TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.

Bang H, Kim Y, Kim D.

J Biol Chem. 2000 Jun 9;275(23):17412-9.

12.

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.

Brohawn SG.

Ann N Y Acad Sci. 2015 Sep;1352:20-32. doi: 10.1111/nyas.12874. Epub 2015 Aug 31. Review.

PMID:
26332952
13.

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13547-52. doi: 10.1073/pnas.1407160111. Epub 2014 Sep 2.

14.

Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2.

Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J.

J Physiol. 2002 Mar 15;539(Pt 3):657-68.

15.

The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.

Liu J, Siyahhan Julnes P, Chen J, Ehrlich S, Walton E, Calhoun VD.

Schizophr Res. 2015 Dec;169(1-3):447-452. doi: 10.1016/j.schres.2015.08.035. Epub 2015 Sep 14.

16.

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.

Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D.

Br J Pharmacol. 2008 Aug;154(8):1680-90. doi: 10.1038/bjp.2008.213. Epub 2008 Jun 2.

17.

Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.

Rubicz R, Yolken R, Alaedini A, Drigalenko E, Charlesworth JC, Carless MA, Severance EG, Krivogorsky B, Dyer TD, Kent JW Jr, Curran JE, Johnson MP, Cole SA, Almasy L, Moses EK, Blangero J, Göring HH.

Genet Epidemiol. 2014 Jul;38(5):439-46. doi: 10.1002/gepi.21817.

18.

Potassium leak channels and the KCNK family of two-P-domain subunits.

Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N.

Nat Rev Neurosci. 2001 Mar;2(3):175-84. Review.

PMID:
11256078
19.

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.

Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S.

Pharmacol Rev. 2005 Dec;57(4):527-40. Review. No abstract available.

20.

Docking motif-guided mapping of the interactome of protein phosphatase-1.

Hendrickx A, Beullens M, Ceulemans H, Den Abt T, Van Eynde A, Nicolaescu E, Lesage B, Bollen M.

Chem Biol. 2009 Apr 24;16(4):365-71. doi: 10.1016/j.chembiol.2009.02.012.

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