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Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.

Xia W, Yin J, Zhang S, Guo C, Li Y, Zhang Y, Zhang A, Jia Z, Chen H.

Cell Physiol Biochem. 2018;49(5):2022-2034. doi: 10.1159/000493713. Epub 2018 Sep 21.


De novo tetrahydrobiopterin biosynthesis is impaired in the inflammed striatum of parkin(-/-) mice.

de Paula Martins R, Glaser V, Aguiar AS Jr, de Paula Ferreira PM, Ghisoni K, da Luz Scheffer D, Lanfumey L, Raisman-Vozari R, Corti O, De Paul AL, da Silva RA, Latini A.

Cell Biol Int. 2018 Jun;42(6):725-733. doi: 10.1002/cbin.10969. Epub 2018 Apr 26.


Loss of Parkin impairs mitochondrial function and leads to muscle atrophy.

Peker N, Donipadi V, Sharma M, McFarlane C, Kambadur R.

Am J Physiol Cell Physiol. 2018 Aug 1;315(2):C164-C185. doi: 10.1152/ajpcell.00064.2017. Epub 2018 Mar 21.


Parkin absence accelerates microtubule aging in dopaminergic neurons.

Cartelli D, Amadeo A, Calogero AM, Casagrande FVM, De Gregorio C, Gioria M, Kuzumaki N, Costa I, Sassone J, Ciammola A, Hattori N, Okano H, Goldwurm S, Roybon L, Pezzoli G, Cappelletti G.

Neurobiol Aging. 2018 Jan;61:66-74. doi: 10.1016/j.neurobiolaging.2017.09.010. Epub 2017 Sep 20.


PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window.

Shen Z, Zheng Y, Wu J, Chen Y, Wu X, Zhou Y, Yuan Y, Lu S, Jiang L, Qin Z, Chen Z, Hu W, Zhang X.

Autophagy. 2017 Mar 4;13(3):473-485. doi: 10.1080/15548627.2016.1274596. Epub 2017 Jan 19.


Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism.

Song L, McMackin M, Nguyen A, Cortopassi G.

Neurobiol Dis. 2017 Apr;100:30-38. doi: 10.1016/j.nbd.2016.12.024. Epub 2016 Dec 29.


Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.

Khan SH, Zhao D, Shah SZ, Hassan MF, Zhu T, Song Z, Zhou X, Yang L.

Cell Mol Neurobiol. 2017 May;37(4):717-728. doi: 10.1007/s10571-016-0407-7. Epub 2016 Jul 18.


Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

Costa DK, Huckestein BR, Edmunds LR, Petersen MC, Nasiri A, Butrico GM, Abulizi A, Harmon DB, Lu C, Mantell BS, Hartman DJ, Camporez JP, O'Doherty RM, Cline GW, Shulman GI, Jurczak MJ.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E105-16. doi: 10.1152/ajpendo.00042.2016. Epub 2016 May 10.


Central Parkin: The evolving role of Parkin in the heart.

Dorn GW 2nd.

Biochim Biophys Acta. 2016 Aug;1857(8):1307-1312. doi: 10.1016/j.bbabio.2016.03.014. Epub 2016 Mar 16. Review.


Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance.

Yung C, Sha D, Li L, Chin LS.

Mol Neurobiol. 2016 Nov;53(9):6270-6287. doi: 10.1007/s12035-015-9537-z. Epub 2015 Nov 13.


Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice.

Williams JA, Ni HM, Ding Y, Ding WX.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1;309(5):G324-40. doi: 10.1152/ajpgi.00108.2015. Epub 2015 Jul 9. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G142.


Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.

Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd.

Circ Res. 2015 Jul 31;117(4):346-51. doi: 10.1161/CIRCRESAHA.117.306859. Epub 2015 Jun 2.


Mitochondrial alterations by PARKIN in dopaminergic neurons using PARK2 patient-specific and PARK2 knockout isogenic iPSC lines.

Shaltouki A, Sivapatham R, Pei Y, Gerencser AA, Momčilović O, Rao MS, Zeng X.

Stem Cell Reports. 2015 May 12;4(5):847-59. doi: 10.1016/j.stemcr.2015.02.019. Epub 2015 Apr 2.


Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.

Williams JA, Ni HM, Haynes A, Manley S, Li Y, Jaeschke H, Ding WX.

J Biol Chem. 2015 Apr 24;290(17):10934-46. doi: 10.1074/jbc.M114.602284. Epub 2015 Mar 9.


Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical features of Parkinson's disease.

Rial D, Castro AA, Machado N, Garção P, Gonçalves FQ, Silva HB, Tomé AR, Köfalvi A, Corti O, Raisman-Vozari R, Cunha RA, Prediger RD.

PLoS One. 2014 Dec 8;9(12):e114216. doi: 10.1371/journal.pone.0114216. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0118526.


The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure.

Benskey MJ, Manfredsson FP, Lookingland KJ, Goudreau JL.

Neurotoxicology. 2015 Jan;46:1-11. doi: 10.1016/j.neuro.2014.11.004. Epub 2014 Nov 20.


Tissue- and cell-specific mitochondrial defect in Parkin-deficient mice.

Damiano M, Gautier CA, Bulteau AL, Ferrando-Miguel R, Gouarne C, Paoli MG, Pruss R, Auchère F, L'Hermitte-Stead C, Bouillaud F, Brice A, Corti O, Lombès A.

PLoS One. 2014 Jun 24;9(6):e99898. doi: 10.1371/journal.pone.0099898. eCollection 2014.


Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice.

Wenqiang C, Lonskaya I, Hebron ML, Ibrahim Z, Olszewski RT, Neale JH, Moussa CE.

Hum Mol Genet. 2014 Sep 15;23(18):4960-9. doi: 10.1093/hmg/ddu211. Epub 2014 May 8.


Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance.

Lonskaya I, Hebron ML, Desforges NM, Schachter JB, Moussa CE.

J Mol Med (Berl). 2014 Apr;92(4):373-86. doi: 10.1007/s00109-013-1112-3. Epub 2013 Dec 13.


Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.

Fournier M, Roux A, Garrigue J, Muriel MP, Blanche P, Lashuel HA, Anderson JP, Barbour R, Huang J, du Montcel ST, Brice A, Corti O.

BMC Neurosci. 2013 Nov 5;14:135. doi: 10.1186/1471-2202-14-135.

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