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Items: 1 to 20 of 78

1.

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E.

J Med Chem. 2017 Apr 13;60(7):2963-2972. doi: 10.1021/acs.jmedchem.6b01890. Epub 2017 Apr 3.

PMID:
28328206
2.

Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia.

Bernstein HG, Müller S, Dobrowolny H, Wolke C, Lendeckel U, Bukowska A, Keilhoff G, Becker A, Trübner K, Steiner J, Bogerts B.

Eur Arch Psychiatry Clin Neurosci. 2017 Aug;267(5):427-443. doi: 10.1007/s00406-016-0757-7. Epub 2016 Dec 29.

PMID:
28035472
3.

A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism.

RamIrez-Expósito MJ, MartInez-Martos JM, Palomeque T, Lorite P.

Indian J Med Res. 2016 Jul;144(1):120-123. doi: 10.4103/0971-5916.193298.

4.

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.

Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Khan YS, Gutiérrez-de-Terán H, Sävmarker J, Ng L, Pham V, Lundbäck T, Jenmalm-Jensen A, Svensson R, Artursson P, Zelleroth S, Engen K, Rosenström U, Larhed M, Åqvist J, Chai SY, Hallberg M.

ACS Chem Neurosci. 2016 Oct 19;7(10):1383-1392. Epub 2016 Aug 8.

PMID:
27501164
5.

Vasopressinase Activity: A Potential Early Biomarker for Detecting Cardiopulmonary Bypass-Associated Acute Kidney Injury?

Kim N, Dai SY, Pang V, Mazer CD.

Thorac Cardiovasc Surg. 2016 Oct;64(7):555-560. Epub 2015 Sep 14.

PMID:
26366890
6.

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.

Hermans SJ, Ascher DB, Hancock NC, Holien JK, Michell BJ, Chai SY, Morton CJ, Parker MW.

Protein Sci. 2015 Feb;24(2):190-9. doi: 10.1002/pro.2604. Epub 2014 Dec 26.

7.

Identification of a missense variant in LNPEP that confers psoriasis risk.

Cheng H, Li Y, Zuo XB, Tang HY, Tang XF, Gao JP, Sheng YJ, Yin XY, Zhou FS, Zhang C, Chen G, Zhu J, Pan Q, Liang B, Zheng XD, Li P, Ding YT, Cheng F, Luo J, Chang RX, Pan GB, Fan X, Wang ZX, Zhang AP, Liu JJ, Yang S, Sun LD, Zhang XJ.

J Invest Dermatol. 2014 Feb;134(2):359-365. doi: 10.1038/jid.2013.317. Epub 2013 Jul 29.

8.

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.

Ascher DB, Cromer BA, Morton CJ, Volitakis I, Cherny RA, Albiston AL, Chai SY, Parker MW.

Biochemistry. 2011 Apr 5;50(13):2611-22. doi: 10.1021/bi101893w. Epub 2011 Mar 9.

PMID:
21348480
9.

Leucyl/cystinyl aminopeptidase gene variants in septic shock.

Nakada TA, Russell JA, Wellman H, Boyd JH, Nakada E, Thain KR, Thair SA, Hirasawa H, Oda S, Walley KR.

Chest. 2011 May;139(5):1042-1049. doi: 10.1378/chest.10-2517. Epub 2011 Feb 17.

PMID:
21330387
10.

Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia.

Landau R, Laverrière A, Bischof P, Irion O, Morales M, Cohen M.

Neuro Endocrinol Lett. 2010;31(1):63-6.

PMID:
20150869
11.

Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women.

Kawai M, Araragi K, Shimizu Y, Hara Y.

Clin Chim Acta. 2009 Feb;400(1-2):37-41. doi: 10.1016/j.cca.2008.10.008. Epub 2008 Oct 26.

PMID:
18996364
12.

Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain.

Ye S, Chai SY, Lew RA, Albiston AL.

Biol Chem. 2007 Apr;388(4):399-403.

PMID:
17391061
13.

Essential role of placental leucine aminopeptidase in gynecologic malignancy.

Mizutani S, Shibata K, Kikkawa F, Hattori A, Tsujimoto M, Ishii M, Kobayashi H.

Expert Opin Ther Targets. 2007 Apr;11(4):453-61. Review.

PMID:
17373876
14.

Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy.

Nomura S, Ito T, Yamamoto E, Sumigama S, Iwase A, Okada M, Shibata K, Ando H, Ino K, Kikkawa F, Mizutani S.

Biochim Biophys Acta. 2005 Aug 1;1751(1):19-25. Review.

PMID:
15894523
15.
16.

Placental leucine aminopeptidase/oxytocinase gene regulation by activator protein-2 in BeWo cell model of human trophoblast differentiation.

Iwanaga K, Nomura S, Ito T, Ikoma Y, Yamamoto E, Okada M, Itakura A, Kikkawa F, Tsujimoto M, Mizutani S.

FEBS Lett. 2003 Sep 25;552(2-3):120-4.

17.

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP).

Lew RA, Mustafa T, Ye S, McDowall SG, Chai SY, Albiston AL.

J Neurochem. 2003 Jul;86(2):344-50.

18.

Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells.

Ikoma Y, Nomura S, Ito T, Katsumata Y, Nakata M, Iwanaga K, Okada M, Kikkawa F, Tamakoshi K, Nagasaka T, Tsujimoto M, Mizutani S.

Mol Hum Reprod. 2003 Feb;9(2):103-10.

PMID:
12569180
19.

Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.

Kikkawa F, Kajiyama H, Ino K, Watanabe Y, Ito M, Nomura S, Itakura A, Tsujimoto M, Mizutani S.

Placenta. 2002 Jul;23(6):483-9.

PMID:
12137746
20.

Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase.

Albiston AL, McDowall SG, Matsacos D, Sim P, Clune E, Mustafa T, Lee J, Mendelsohn FA, Simpson RJ, Connolly LM, Chai SY.

J Biol Chem. 2001 Dec 28;276(52):48623-6. Epub 2001 Nov 13.

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