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Items: 1 to 20 of 622

1.

The Biased G-Protein-Coupled Receptor Agonism Bridges the Gap between the Insulin Receptor and the Metabolic Syndrome.

Liauchonak I, Dawoud F, Riat Y, Qorri B, Sambi M, Jain J, Kalaydina RV, Mendonza N, Bajwa K, Szewczuk MR.

Int J Mol Sci. 2018 Feb 17;19(2). pii: E575. doi: 10.3390/ijms19020575. Review.

2.

INSR-Related Severe Syndromic Insulin Resistance.

Ben Harouch S, Klar A, Falik Zaccai TC.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018.
2018 Jan 25.

3.

Insulin-induced translocation of IR to the nucleus in insulin responsive cells requires a nuclear translocation sequence.

Kesten D, Horovitz-Fried M, Brutman-Barazani T, Sampson SR.

Biochim Biophys Acta Mol Cell Res. 2018 Apr;1865(4):551-559. doi: 10.1016/j.bbamcr.2018.01.004. Epub 2018 Jan 6.

PMID:
29317261
4.

Rapid Non-Enzymatic Glycation of the Insulin Receptor under Hyperglycemic Conditions Inhibits Insulin Binding In Vitro: Implications for Insulin Resistance.

Rhinesmith T, Turkette T, Root-Bernstein R.

Int J Mol Sci. 2017 Dec 2;18(12). pii: E2602. doi: 10.3390/ijms18122602.

5.

Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle.

Renna LV, Bosè F, Iachettini S, Fossati B, Saraceno L, Milani V, Colombo R, Meola G, Cardani R.

PLoS One. 2017 Sep 15;12(9):e0184987. doi: 10.1371/journal.pone.0184987. eCollection 2017.

6.

INSR gene polymorphisms correlate with sensitivity to platinum-based chemotherapy and prognosis in patients with epithelial ovarian cancer.

Hu JL, Hu XL, Han Q, Guo AY, Wang CJ, Wen YY, Cang SD.

Gene Ther. 2017 Jul;24(7):392-398. doi: 10.1038/gt.2017.26. Epub 2017 Apr 24.

PMID:
28436941
7.

Inverse relationship between insulin receptor expression and progression in renal cell carcinoma.

Takahashi M, Inoue T, Huang M, Numakura K, Tsuruta H, Saito M, Maeno A, Nakamura E, Narita S, Tsuchiya N, Habuchi T.

Oncol Rep. 2017 May;37(5):2929-2941. doi: 10.3892/or.2017.5552. Epub 2017 Apr 5.

PMID:
28393204
8.

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein.

Boado RJ, Pardridge WM.

Mol Pharm. 2017 Apr 3;14(4):1271-1277. doi: 10.1021/acs.molpharmaceut.6b01166. Epub 2017 Mar 16.

PMID:
28279069
9.

The INSR rs2059806 single nucleotide polymorphism, a genetic risk factor for vascular and metabolic disease, associates with pre-eclampsia.

Andraweera PH, Gatford KL, Dekker GA, Leemaqz S, Jayasekara RW, Dissanayake VHW, McCowan L, Roberts CT.

Reprod Biomed Online. 2017 Apr;34(4):392-398. doi: 10.1016/j.rbmo.2017.01.001. Epub 2017 Jan 11.

PMID:
28117222
10.
11.

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.

PMID:
27617429
12.

A novel insulin receptor mutation in an adolescent with acanthosis nigricans and hyperandrogenism.

Krishnamurthy M, Pingul MM.

J Pediatr Endocrinol Metab. 2016 Oct 1;29(10):1201-1205. doi: 10.1515/jpem-2015-0384.

PMID:
27505086
13.

Identification of a Novel Homozygous INSR Variant in a Patient with Rabson-Mendenhall Syndrome from the United Arab Emirates.

Bastaki F, Nair P, Mohamed M, Khadora MM, Saif F, Tawfiq N, Al-Ali MT, Hamzeh AR.

Horm Res Paediatr. 2017;87(1):64-68. doi: 10.1159/000447090. Epub 2016 Jun 22.

PMID:
27326825
14.

Reduced Insulin Receptor Expression Enhances Proximal Tubule Gluconeogenesis.

Pandey G, Shankar K, Makhija E, Gaikwad A, Ecelbarger C, Mandhani A, Srivastava A, Tiwari S.

J Cell Biochem. 2017 Feb;118(2):276-285. doi: 10.1002/jcb.25632. Epub 2016 Jun 27.

PMID:
27322100
15.

Novel method demonstrates differential ligand activation and phosphatase-mediated deactivation of insulin receptor tyrosine-specific phosphorylation.

Cieniewicz AM, Cooper PR, McGehee J, Lingham RB, Kihm AJ.

Cell Signal. 2016 Aug;28(8):1037-47. doi: 10.1016/j.cellsig.2016.05.001. Epub 2016 May 4.

PMID:
27155325
16.

Inhibition of D4 Dopamine Receptors on Insulin Receptor Expression and Effect in Renal Proximal Tubule Cells.

Zhang Y, Ren H, Lu X, He D, Han Y, Wang H, Zeng C, Shi W.

J Am Heart Assoc. 2016 Apr 22;5(4). pii: e002448. doi: 10.1161/JAHA.115.002448.

17.

Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein.

Hossain MU, Khan MA, Rakib-Uz-Zaman SM, Ali MT, Islam MS, Keya CA, Salimullah M.

Biomed Res Int. 2016;2016:3187647. doi: 10.1155/2016/3187647. Epub 2016 Feb 28.

18.

Disruption of insulin receptor function inhibits proliferation in endocrine-resistant breast cancer cells.

Chan JY, LaPara K, Yee D.

Oncogene. 2016 Aug 11;35(32):4235-43. doi: 10.1038/onc.2015.488. Epub 2016 Feb 15.

19.

First molecular diagnosis of Donohue syndrome in Africa: novel unusual insertion/deletion mutation in the INSR gene.

Siala-Sahnoun O, Dhieb D, Ben Thabet A, Hmida N, Belguith N, Fakhfakh F.

Mol Biol Rep. 2016 Mar;43(3):165-73. doi: 10.1007/s11033-016-3951-9. Epub 2016 Feb 13.

PMID:
26874853
20.

Single-Nucleotide Polymorphism on Exon 17 of Insulin Receptor Gene Influences Insulin Resistance in PCOS: A Pilot Study on North Indian Women.

Gangopadhyay S, Agrawal N, Batra A, Kabi BC, Gupta A.

Biochem Genet. 2016 Apr;54(2):158-68. doi: 10.1007/s10528-015-9708-7. Epub 2015 Dec 31.

PMID:
26721804

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