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GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis.

Sanderlin EJ, Leffler NR, Lertpiriyapong K, Cai Q, Hong H, Bakthavatchalu V, Fox JG, Oswald JZ, Justus CR, Krewson EA, O'Rourke D, Yang LV.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):569-584. doi: 10.1016/j.bbadis.2016.12.005. Epub 2016 Dec 7.


Deletion of proton-sensing receptor GPR4 associates with lower blood pressure and lower binding of angiotensin II receptor in SFO.

Sun X, Tommasi E, Molina D, Sah R, Brosnihan KB, Diz D, Petrovic S.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1260-F1266. doi: 10.1152/ajprenal.00410.2016. Epub 2016 Sep 28.


GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway.

Justus CR, Yang LV.

Exp Cell Res. 2015 May 15;334(1):100-13. doi: 10.1016/j.yexcr.2015.03.022. Epub 2015 Apr 4.


The proton-activated receptor GPR4 modulates glucose homeostasis by increasing insulin sensitivity.

Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA.

Cell Physiol Biochem. 2013;32(5):1403-16.


Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor.

Wyder L, Suply T, Ricoux B, Billy E, Schnell C, Baumgarten BU, Maira SM, Koelbing C, Ferretti M, Kinzel B, Müller M, Seuwen K, Ludwig MG.

Angiogenesis. 2011 Dec;14(4):533-44. doi: 10.1007/s10456-011-9238-9. Epub 2011 Nov 2.


Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor.

Castellone RD, Leffler NR, Dong L, Yang LV.

Cancer Lett. 2011 Dec 22;312(2):197-208. doi: 10.1016/j.canlet.2011.08.013. Epub 2011 Aug 22.


Deletion of the pH sensor GPR4 decreases renal acid excretion.

Sun X, Yang LV, Tiegs BC, Arend LJ, McGraw DW, Penn RB, Petrovic S.

J Am Soc Nephrol. 2010 Oct;21(10):1745-55. doi: 10.1681/ASN.2009050477. Epub 2010 Aug 26.


Involvement of the G-protein-coupled receptor 4 in RANKL expression by osteoblasts in an acidic environment.

Okito A, Nakahama K, Akiyama M, Ono T, Morita I.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):435-40. doi: 10.1016/j.bbrc.2015.01.142. Epub 2015 Feb 7.


Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.

Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON.

Mol Cell Biol. 2007 Feb;27(4):1334-47. Epub 2006 Dec 4.


CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, Abdala AP, Liu BH, Gourine AV, Teschemacher AG, Kasparov S.

Neuropharmacology. 2018 Aug;138:381-392. doi: 10.1016/j.neuropharm.2018.06.007. Epub 2018 Jun 9.


Adaptation by the collecting duct to an exogenous acid load is blunted by deletion of the proton-sensing receptor GPR4.

Sun X, Stephens L, DuBose TD Jr, Petrovic S.

Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F120-36. doi: 10.1152/ajprenal.00507.2014. Epub 2015 May 13.


Ischemia/reperfusion-induced CHOP expression promotes apoptosis and impairs renal function recovery: the role of acidosis and GPR4.

Dong B, Zhou H, Han C, Yao J, Xu L, Zhang M, Fu Y, Xia Q.

PLoS One. 2014 Oct 24;9(10):e110944. doi: 10.1371/journal.pone.0110944. eCollection 2014.


GPR4 knockout improves renal ischemia-reperfusion injury and inhibits apoptosis via suppressing the expression of CHOP.

Dong B, Zhang X, Fan Y, Cao S, Zhang X.

Biochem J. 2017 Dec 1;474(24):4065-4074. doi: 10.1042/BCJ20170676.


PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA.

Science. 2015 Jun 12;348(6240):1255-60. doi: 10.1126/science.aaa0922. Epub 2015 Jun 11.


Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells.

Kamide Y, Ishizuka T, Tobo M, Tsurumaki H, Aoki H, Mogi C, Nakakura T, Yatomi M, Ono A, Koga Y, Sato K, Hisada T, Dobashi K, Yamada M, Okajima F.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):949-55. doi: 10.1016/j.bbrc.2015.07.077. Epub 2015 Jul 18.


Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.

Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M.

J Biol Chem. 2005 Jul 29;280(30):28044-52. Epub 2005 May 31.


The G protein-coupled receptor repertoires of human and mouse.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8. Epub 2003 Apr 4.

18. an atlas of gene expression patterns in the mouse embryo.

Visel A, Thaller C, Eichele G.

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6.


BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.

Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T.

PLoS Biol. 2006 Apr;4(4):e86. Epub 2006 Mar 28. No abstract available.


Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.

Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A.

Genome Res. 2008 Oct;18(10):1670-9. doi: 10.1101/gr.078352.108. Epub 2008 Sep 17.

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