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Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel.

Tipton AR, Nyabuto GO, Trendel JA, Mazur TM, Wilson JP, Wadi S, Justinger JS, Moore GL, Nguyen PT, Vestal DJ.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1617-23. doi: 10.1016/j.bbrc.2016.08.169. Epub 2016 Aug 31.


Tetrameric assembly of hGBP1 is crucial for both stimulated GMP formation and antiviral activity.

Pandita E, Rajan S, Rahman S, Mullick R, Das S, Sau AK.

Biochem J. 2016 Jun 15;473(12):1745-57. doi: 10.1042/BCJ20160220. Epub 2016 Apr 12.


Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii.

Johnston AC, Piro A, Clough B, Siew M, Virreira Winter S, Coers J, Frickel EM.

Cell Microbiol. 2016 Aug;18(8):1056-64. doi: 10.1111/cmi.12579. Epub 2016 Mar 10.


Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.

Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M.

Cancer Sci. 2014 Oct;105(10):1351-9. doi: 10.1111/cas.12489. Epub 2014 Sep 29.


Triphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-terminal helices: a joint double electron-electron resonance and FRET study.

Vöpel T, Hengstenberg CS, Peulen TO, Ajaj Y, Seidel CA, Herrmann C, Klare JP.

Biochemistry. 2014 Jul 22;53(28):4590-600. doi: 10.1021/bi500524u. Epub 2014 Jul 14.


Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor.

Ostler N, Britzen-Laurent N, Liebl A, Naschberger E, Lochnit G, Ostler M, Forster F, Kunzelmann P, Ince S, Supper V, Praefcke GJ, Schubert DW, Stockinger H, Herrmann C, Stürzl M.

Mol Cell Biol. 2014 Jan;34(2):196-209. doi: 10.1128/MCB.00664-13. Epub 2013 Nov 4.


GBP-1 acts as a tumor suppressor in colorectal cancer cells.

Britzen-Laurent N, Lipnik K, Ocker M, Naschberger E, Schellerer VS, Croner RS, Vieth M, Waldner M, Steinberg P, Hohenadl C, Stürzl M.

Carcinogenesis. 2013 Jan;34(1):153-62. doi: 10.1093/carcin/bgs310. Epub 2012 Oct 6.


Insight into temperature dependence of GTPase activity in human guanylate binding protein-1.

Rani A, Pandita E, Rahman S, Deep S, Sau AK.

PLoS One. 2012;7(7):e40487. doi: 10.1371/journal.pone.0040487. Epub 2012 Jul 11.


Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis.

Yu CJ, Chang KP, Chang YJ, Hsu CW, Liang Y, Yu JS, Chi LM, Chang YS, Wu CC.

J Proteome Res. 2011 Aug 5;10(8):3778-88. doi: 10.1021/pr2004133. Epub 2011 Jul 19.


Role of guanylate binding protein-1 in vascular defects associated with chronic inflammatory diseases.

Hammon M, Herrmann M, Bleiziffer O, Pryymachuk G, Andreoli L, Munoz LE, Amann KU, Mondini M, Gariglio M, Airó P, Schellerer VS, Hatzopoulos AK, Horch RE, Kneser U, Stürzl M, Naschberger E.

J Cell Mol Med. 2011 Jul;15(7):1582-92. doi: 10.1111/j.1582-4934.2010.01146.x.


Interferon gamma-induced human guanylate binding protein 1 inhibits mammary tumor growth in mice.

Lipnik K, Naschberger E, Gonin-Laurent N, Kodajova P, Petznek H, Rungaldier S, Astigiano S, Ferrini S, Stürzl M, Hohenadl C.

Mol Med. 2010 May-Jun;16(5-6):177-87. doi: 10.2119/molmed.2009.00172. Epub 2010 Feb 5.


Mechanism of GTPase-activity-induced self-assembly of human guanylate binding protein 1.

Vöpel T, Syguda A, Britzen-Laurent N, Kunzelmann S, Lüdemann MB, Dovengerds C, Stürzl M, Herrmann C.

J Mol Biol. 2010 Jul 2;400(1):63-70. doi: 10.1016/j.jmb.2010.04.053. Epub 2010 May 5.


Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis.

Vöpel T, Kunzelmann S, Herrmann C.

FEBS Lett. 2009 Jun 18;583(12):1923-7. doi: 10.1016/j.febslet.2009.05.027. Epub 2009 May 20.


Role of individual domains and identification of internal gap in human guanylate binding protein-1.

Abdullah N, Srinivasan B, Modiano N, Cresswell P, Sau AK.

J Mol Biol. 2009 Feb 27;386(3):690-703. doi: 10.1016/j.jmb.2008.12.060. Epub 2009 Jan 3.


Angiostatic immune reaction in colorectal carcinoma: Impact on survival and perspectives for antiangiogenic therapy.

Naschberger E, Croner RS, Merkel S, Dimmler A, Tripal P, Amann KU, Kremmer E, Brueckl WM, Papadopoulos T, Hohenadl C, Hohenberger W, Stürzl M.

Int J Cancer. 2008 Nov 1;123(9):2120-9. doi: 10.1002/ijc.23764.


Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.

Naschberger E, Lubeseder-Martellato C, Meyer N, Gessner R, Kremmer E, Gessner A, Stürzl M.

Am J Pathol. 2006 Sep;169(3):1088-99.


Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor.

Modiano N, Lu YE, Cresswell P.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8680-5. Epub 2005 Jun 3.

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