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Upregulation of Tyrosine Kinase FYN in Human Thyroid Carcinoma: Role in Modulating Tumor Cell Proliferation, Invasion, and Migration.

Zheng J, Li H, Xu D, Zhu H.

Cancer Biother Radiopharm. 2017 Nov;32(9):320-326. doi: 10.1089/cbr.2017.2218.


Regulatory region genetic variation is associated with FYN expression in Alzheimer's disease.

Zahratka JA, Shao Y, Shaw M, Todd K, Formica SV, Khrestian M, Montine T, Leverenz JB, Bekris LM.

Neurobiol Aging. 2017 Mar;51:43-53. doi: 10.1016/j.neurobiolaging.2016.11.001. Epub 2016 Nov 15.


Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.

Huculeci R, Cilia E, Lyczek A, Buts L, Houben K, Seeliger MA, van Nuland N, Lenaerts T.

Structure. 2016 Nov 1;24(11):1947-1959. doi: 10.1016/j.str.2016.08.016. Epub 2016 Sep 29.


FYN promotes breast cancer progression through epithelial-mesenchymal transition.

Xie YG, Yu Y, Hou LK, Wang X, Zhang B, Cao XC.

Oncol Rep. 2016 Aug;36(2):1000-6. doi: 10.3892/or.2016.4894. Epub 2016 Jun 22.


SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer.

Gururajan M, Cavassani KA, Sievert M, Duan P, Lichterman J, Huang JM, Smith B, You S, Nandana S, Chu GC, Mink S, Josson S, Liu C, Morello M, Jones LW, Kim J, Freeman MR, Bhowmick N, Zhau HE, Chung LW, Posadas EM.

Oncotarget. 2015 Dec 29;6(42):44072-83. doi: 10.18632/oncotarget.6398.


An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease.

Lee C, Low CY, Francis PT, Attems J, Wong PT, Lai MK, Tan MG.

J Neurochem. 2016 Feb;136(3):637-50. doi: 10.1111/jnc.13429. Epub 2015 Dec 10.


Role of the Fyn -93A>G polymorphism (rs706895) in acute rejection after liver transplantation.

Thude H, Kramer K, Peine S, Sterneck M, Nashan B, Koch M.

Hum Immunol. 2015 Sep;76(9):657-62. doi: 10.1016/j.humimm.2015.09.013. Epub 2015 Sep 25.


Structural insights into the intertwined dimer of fyn SH2.

Huculeci R, Garcia-Pino A, Buts L, Lenaerts T, van Nuland N.

Protein Sci. 2015 Dec;24(12):1964-78. doi: 10.1002/pro.2806. Epub 2015 Oct 7.


Association between FYN polymorphisms and defense mechanisms in healthy Chinese-Han subjects.

Jin Q, Huang Y, Li X, Cong Z, Zhu G, Jiang W, Gao S, Ma H.

Psychiatry Res. 2014 Dec 15;220(1-2):723-4. doi: 10.1016/j.psychres.2014.07.068. Epub 2014 Aug 1. No abstract available.


Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion.

Fenton SE, Hutchens KA, Denning MF.

Mol Carcinog. 2015 Oct;54(10):1181-93. doi: 10.1002/mc.22190. Epub 2014 Jun 29.


The association of single nucleotide polymorphism of the Fyn gene with sporadic Alzheimer's disease in the Chinese Han population.

Li J, Zhou HD, Deng J, Zhu J, Li L, Zhang M, Zeng F, Wang YJ; Chongqing Aging Study Group.

Neurosci Lett. 2014 Jul 11;575:80-4. doi: 10.1016/j.neulet.2014.05.020. Epub 2014 May 20.


Immunoglobulin E induces VEGF production in mast cells and potentiates their pro-tumorigenic actions through a Fyn kinase-dependent mechanism.

Jiménez-Andrade GY, Ibarra-Sánchez A, González D, Lamas M, González-Espinosa C.

J Hematol Oncol. 2013 Aug 2;6:56. doi: 10.1186/1756-8722-6-56.


Genetic variation of FYN contributes to the molecular mechanisms of coping styles in healthy Chinese-Han participants.

Zhao X, Li J, Huang Y, Jin Q, Ma H, Wang Y, Wu L, Li J, Zhu G.

Psychiatr Genet. 2013 Oct;23(5):214-6. doi: 10.1097/YPG.0b013e328364365d.


Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells.

Thompson WR, Guilluy C, Xie Z, Sen B, Brobst KE, Yen SS, Uzer G, Styner M, Case N, Burridge K, Rubin J.

Stem Cells. 2013 Nov;31(11):2528-37. doi: 10.1002/stem.1476.


Association study of the Fyn gene with schizophrenia in the Chinese-Han population.

Wu L, Huang Y, Li J, Zhao H, Du H, Jin Q, Zhao X, Ma H, Zhu G.

Psychiatr Genet. 2013 Feb;23(1):39-40. doi: 10.1097/YPG.0b013e328358640b. No abstract available.


HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.

Nakashima K, Takeuchi K, Chihara K, Horiguchi T, Sun X, Deng L, Shoji I, Hotta H, Sada K.

PLoS One. 2012;7(10):e46634. doi: 10.1371/journal.pone.0046634. Epub 2012 Oct 16.


In silico study of Alzheimer's disease in relation to FYN gene.

Anbarasu A, Kundu A.

Interdiscip Sci. 2012 Jun;4(2):153-60. doi: 10.1007/s12539-012-0123-z. Epub 2012 Jul 29.


Fyn inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury.

Koo JH, Lee WH, Lee CG, Kim SG.

Mol Pharmacol. 2012 Jul;82(1):27-36. doi: 10.1124/mol.111.077149. Epub 2012 Apr 2.


Purification, crystallization and preliminary X-ray diffraction analysis of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.

Huculeci R, Buts L, Lenaerts T, van Nuland NA, Garcia-Pino A.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Mar 1;68(Pt 3):359-64. doi: 10.1107/S1744309112004186. Epub 2012 Feb 29.


Kinetic consequences of native state optimization of surface-exposed electrostatic interactions in the Fyn SH3 domain.

Zarrine-Afsar A, Zhang Z, Schweiker KL, Makhatadze GI, Davidson AR, Chan HS.

Proteins. 2012 Mar;80(3):858-70. doi: 10.1002/prot.23243. Epub 2011 Dec 13.


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