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β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.

Hartmann S, Zheng F, Kyncl MC, Karch S, Voelkl K, Zott B, D'Avanzo C, Lomoio S, Tesco G, Kim DY, Alzheimer C, Huth T.

J Neurosci. 2018 Apr 4;38(14):3480-3494. doi: 10.1523/JNEUROSCI.2643-17.2018. Epub 2018 Mar 5.


BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.

Hou H, Fan Q, He W, Suh H, Hu X, Yan R.

Stem Cell Reports. 2017 Jul 11;9(1):217-230. doi: 10.1016/j.stemcr.2017.05.030. Epub 2017 Jun 29.


BACE1 regulates the proliferation and cellular functions of Schwann cells.

Hu X, Hou H, Bastian C, He W, Qiu S, Ge Y, Yin X, Kidd GJ, Brunet S, Trapp BD, Baltan S, Yan R.

Glia. 2017 May;65(5):712-726. doi: 10.1002/glia.23122. Epub 2017 Feb 13.


Effects of chronic variable stress on cognition and Bace1 expression among wild-type mice.

Cordner ZA, Tamashiro KL.

Transl Psychiatry. 2016 Jul 12;6(7):e854. doi: 10.1038/tp.2016.127.


Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse.

He XL, Yan N, Chen XS, Qi YW, Yan Y, Cai Z.

Pharmacol Rep. 2016 Oct;68(5):975-82. doi: 10.1016/j.pharep.2016.05.006. Epub 2016 Jun 30.


Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice.

Luo G, Xu H, Huang Y, Mo D, Song L, Jia B, Wang B, Jin Z, Miao Z.

Biomed Res Int. 2016;2016:8380618. doi: 10.1155/2016/8380618. Epub 2016 May 18.


Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.

Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R.

Acta Neuropathol. 2016 Aug;132(2):235-56. doi: 10.1007/s00401-016-1558-9. Epub 2016 Mar 18.


Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer's disease.

Zhang JS, Zhou SF, Wang Q, Guo JN, Liang HM, Deng JB, He WY.

Neuroscience. 2016 Jun 14;325:1-9. doi: 10.1016/j.neuroscience.2016.03.024. Epub 2016 Mar 14.


Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

Jiang Y, Rigoglioso A, Peterhoff CM, Pawlik M, Sato Y, Bleiwas C, Stavrides P, Smiley JF, Ginsberg SD, Mathews PM, Levy E, Nixon RA.

Neurobiol Aging. 2016 Mar;39:90-8. doi: 10.1016/j.neurobiolaging.2015.11.013. Epub 2015 Dec 2.


BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.

Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S.

J Cereb Blood Flow Metab. 2016 Jul;36(7):1281-94. doi: 10.1177/0271678X15606463. Epub 2015 Oct 13.


Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice.

MacPherson RE, Baumeister P, Peppler WT, Wright DC, Little JP.

J Appl Physiol (1985). 2015 Nov 15;119(10):1097-104. doi: 10.1152/japplphysiol.00299.2015. Epub 2015 Sep 24.


1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.

Rombouts FJ, Tresadern G, Delgado O, Martínez-Lamenca C, Van Gool M, García-Molina A, Alonso de Diego SA, Oehlrich D, Prokopcova H, Alonso JM, Austin N, Borghys H, Van Brandt S, Surkyn M, De Cleyn M, Vos A, Alexander R, Macdonald G, Moechars D, Gijsen H, Trabanco AA.

J Med Chem. 2015 Oct 22;58(20):8216-35. doi: 10.1021/acs.jmedchem.5b01101. Epub 2015 Oct 10.


A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.

Neumann U, Rueeger H, Machauer R, Veenstra SJ, Lueoend RM, Tintelnot-Blomley M, Laue G, Beltz K, Vogg B, Schmid P, Frieauff W, Shimshek DR, Staufenbiel M, Jacobson LH.

Mol Neurodegener. 2015 Sep 3;10:44. doi: 10.1186/s13024-015-0033-8.


Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.

Devi L, Ohno M.

Neuroscience. 2015 Oct 29;307:128-37. doi: 10.1016/j.neuroscience.2015.08.037. Epub 2015 Aug 24.


Electroacupuncture Reduces Aβ Production and BACE1 Expression in SAMP8 Mice.

Dong WG, Wang F, Chen Y, Zheng XH, Xie YC, Guo WQ, Shi H.

Front Aging Neurosci. 2015 Jul 29;7:148. doi: 10.3389/fnagi.2015.00148. eCollection 2015.


All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling.

Wang R, Chen S, Liu Y, Diao S, Xue Y, You X, Park EA, Liao FF.

J Biol Chem. 2015 Sep 11;290(37):22532-42. doi: 10.1074/jbc.M115.662908. Epub 2015 Aug 3.


Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Dislich B, Wohlrab F, Bachhuber T, Müller SA, Kuhn PH, Hogl S, Meyer-Luehmann M, Lichtenthaler SF.

Mol Cell Proteomics. 2015 Oct;14(10):2550-63. doi: 10.1074/mcp.M114.041533. Epub 2015 Jul 2.


Loss of Bace1 in mice does not alter the severity of caerulein induced pancreatitis.

Heindl M, Tuennemann J, Sommerer I, Mössner J, Hoffmeister A.

PLoS One. 2015 May 11;10(5):e0125556. doi: 10.1371/journal.pone.0125556. eCollection 2015.


Physiological and behavioral effects of amphetamine in BACE1(-/-) mice.

Paredes RM, Piccart E, Navaira E, Cruz D, Javors MA, Koek W, Beckstead MJ, Walss-Bass C.

Genes Brain Behav. 2015 Jun;14(5):411-8. doi: 10.1111/gbb.12222. Epub 2015 May 21.


Axonal and Schwann cell BACE1 is equally required for remyelination of peripheral nerves.

Hu X, Hu J, Dai L, Trapp B, Yan R.

J Neurosci. 2015 Mar 4;35(9):3806-14. doi: 10.1523/JNEUROSCI.5207-14.2015.

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