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Items: 1 to 20 of 35

1.

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM.

Cancer Res. 2017 Mar 15;77(6):1427-1438. doi: 10.1158/0008-5472.CAN-16-0852. Epub 2017 Jan 20.

2.

Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.

Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J.

J Biol Chem. 2015 Feb 6;290(6):3377-89. doi: 10.1074/jbc.M114.608471. Epub 2014 Dec 5.

3.

Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.

Zhang ZH, Lu YY, Yue J.

PLoS One. 2013 Jun 12;8(6):e66077. doi: 10.1371/journal.pone.0066077. Print 2013.

4.

Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis.

Notomi T, Ezura Y, Noda M.

J Biol Chem. 2012 Oct 12;287(42):35057-64. doi: 10.1074/jbc.M111.328930. Epub 2012 Jul 25.

5.

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.

Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA.

Cell Calcium. 2016 Jan;59(1):32-40. doi: 10.1016/j.ceca.2015.12.004. Epub 2015 Dec 23.

6.

Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.

García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.

J Physiol. 2016 Jun 1;594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4.

7.

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel RA, Bolton EL, Lin WK, Aston D, Wang Y, Liu W, Wang X, Burton RA, Bloor-Young D, Shade KT, Ruas M, Parrington J, Churchill GC, Lei M, Galione A, Terrar DA.

J Biol Chem. 2015 Dec 11;290(50):30087-98. doi: 10.1074/jbc.M115.684076. Epub 2015 Oct 5.

8.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A, Ruas M, Collins SC, Parkesh R, Clough F, Pillinger T, Coltart G, Rietdorf K, Royle A, Johnson P, Braun M, Zhang Q, Sones W, Shimomura K, Morgan AJ, Lewis AM, Chuang KT, Tunn R, Gadea J, Teboul L, Heister PM, Tynan PW, Bellomo EA, Rutter GA, Rorsman P, Churchill GC, Parrington J, Galione A.

J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.

9.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A.

EMBO J. 2015 Jul 2;34(13):1743-58. doi: 10.15252/embj.201490009. Epub 2015 Apr 14.

10.

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

Lear PV, González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C.

Endocrinology. 2015 Mar;156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29.

11.

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.

PMID:
25144390
12.

TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.

Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.

Mol Cell Biol. 2014 Nov;34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18.

13.

TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle.

Tugba Durlu-Kandilci N, Ruas M, Chuang KT, Brading A, Parrington J, Galione A.

J Biol Chem. 2010 Aug 6;285(32):24925-32. doi: 10.1074/jbc.M110.129833. Epub 2010 Jun 14.

14.

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H.

Cell. 2012 Oct 12;151(2):372-83. doi: 10.1016/j.cell.2012.08.036.

15.

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

Schieder M, Rötzer K, Brüggemann A, Biel M, Wahl-Schott CA.

J Biol Chem. 2010 Jul 9;285(28):21219-22. doi: 10.1074/jbc.C110.143123. Epub 2010 May 21.

16.

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.

Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.

Pflugers Arch. 2009 Sep;458(5):891-9. doi: 10.1007/s00424-009-0690-y. Epub 2009 Jun 26.

17.

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: implications for lysosomal function.

Neely Kayala KM, Dickinson GD, Minassian A, Walls KC, Green KN, Laferla FM.

Brain Res. 2012 Dec 13;1489:8-16. doi: 10.1016/j.brainres.2012.10.036. Epub 2012 Oct 24.

18.

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.

Favia A, Desideri M, Gambara G, D'Alessio A, Ruas M, Esposito B, Del Bufalo D, Parrington J, Ziparo E, Palombi F, Galione A, Filippini A.

Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4706-15. doi: 10.1073/pnas.1406029111. Epub 2014 Oct 20.

19.

Identification of a novel gene for diabetic traits in rats, mice, and humans.

Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J; Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC.

Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.

20.

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D.

Cell. 2013 Feb 14;152(4):778-790. doi: 10.1016/j.cell.2013.01.023. Epub 2013 Feb 7.

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