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Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice.

Chen E, Kwon YT, Lim MS, Dubé ID, Hough MR.

Oncogene. 2006 Sep 21;25(42):5752-63. Epub 2006 Jul 24.


Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

An JY, Seo JW, Tasaki T, Lee MJ, Varshavsky A, Kwon YT.

Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6212-7. Epub 2006 Apr 10.


Behavioral characterization of mice lacking the ubiquitin ligase UBR1 of the N-end rule pathway.

Balogh SA, McDowell CS, Denenberg VH.

Genes Brain Behav. 2002 Nov;1(4):223-9.


Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway.

Lee MJ, Pal K, Tasaki T, Roy S, Jiang Y, An JY, Banerjee R, Kwon YT.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):100-5. Epub 2007 Dec 27.


The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.

Piatkov KI, Brower CS, Varshavsky A.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1839-47. doi: 10.1073/pnas.1207786109. Epub 2012 Jun 5.


Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.

Ozawa Y, Nakao K, Kurihara T, Shimazaki T, Shimmura S, Ishida S, Yoshimura A, Tsubota K, Okano H.

J Biol Chem. 2008 Sep 5;283(36):24561-70. doi: 10.1074/jbc.M802238200. Epub 2008 Jul 9.


Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.

Kwak KS, Zhou X, Solomon V, Baracos VE, Davis J, Bannon AW, Boyle WJ, Lacey DL, Han HQ.

Cancer Res. 2004 Nov 15;64(22):8193-8.


An essential role of N-terminal arginylation in cardiovascular development.

Kwon YT, Kashina AS, Davydov IV, Hu RG, An JY, Seo JW, Du F, Varshavsky A.

Science. 2002 Jul 5;297(5578):96-9.


The substrate recognition domains of the N-end rule pathway.

Tasaki T, Zakrzewska A, Dudgeon DD, Jiang Y, Lazo JS, Kwon YT.

J Biol Chem. 2009 Jan 16;284(3):1884-95. doi: 10.1074/jbc.M803641200. Epub 2008 Nov 13.


Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain.

Du F, Navarro-Garcia F, Xia Z, Tasaki T, Varshavsky A.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14110-5. Epub 2002 Oct 21.


The mouse and human genes encoding the recognition component of the N-end rule pathway.

Kwon YT, Reiss Y, Fried VA, Hershko A, Yoon JK, Gonda DK, Sangan P, Copeland NG, Jenkins NA, Varshavsky A.

Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898-903.


Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).

Zenker M, Mayerle J, Lerch MM, Tagariello A, Zerres K, Durie PR, Beier M, Hülskamp G, Guzman C, Rehder H, Beemer FA, Hamel B, Vanlieferinghen P, Gershoni-Baruch R, Vieira MW, Dumic M, Auslender R, Gil-da-Silva-Lopes VL, Steinlicht S, Rauh M, Shalev SA, Thiel C, Ekici AB, Winterpacht A, Kwon YT, Varshavsky A, Reis A.

Nat Genet. 2005 Dec;37(12):1345-50. Epub 2005 Nov 20. Erratum in: Nat Genet. 2006 Feb;38(2):265. Ekici, Arif B [added].


Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.

Kwon YT, Xia Z, Davydov IV, Lecker SH, Varshavsky A.

Mol Cell Biol. 2001 Dec;21(23):8007-21.


Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway.

Kwon YT, Balogh SA, Davydov IV, Kashina AS, Yoon JK, Xie Y, Gaur A, Hyde L, Denenberg VH, Varshavsky A.

Mol Cell Biol. 2000 Jun;20(11):4135-48.


Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

Lee PC, Sowa ME, Gygi SP, Harper JW.

Mol Cell. 2011 Aug 5;43(3):392-405. doi: 10.1016/j.molcel.2011.05.034.


Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.

Kwon YT, Xia Z, An JY, Tasaki T, Davydov IV, Seo JW, Sheng J, Xie Y, Varshavsky A.

Mol Cell Biol. 2003 Nov;23(22):8255-71.


Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

Tasaki T, Sohr R, Xia Z, Hellweg R, Hörtnagl H, Varshavsky A, Kwon YT.

J Biol Chem. 2007 Jun 22;282(25):18510-20. Epub 2007 Apr 26.


Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line.

Yu X, Bauer K, Wernhoff P, Koczan D, Möller S, Thiesen HJ, Ibrahim SM.

J Immunol. 2006 Nov 15;177(10):7042-9.


Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.

Farber CR, Corva PM, Medrano JF.

BMC Genomics. 2006 May 2;7:102.

20. an atlas of gene expression patterns in the mouse embryo.

Visel A, Thaller C, Eichele G.

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6.

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