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Items: 1 to 20 of 137


The giant protein titin regulates the length of the striated muscle thick filament.

Tonino P, Kiss B, Strom J, Methawasin M, Smith JE 3rd, Kolb J, Labeit S, Granzier H.

Nat Commun. 2017 Oct 19;8(1):1041. doi: 10.1038/s41467-017-01144-9.


Effect of exercise on passive myocardial stiffness in mice with diastolic dysfunction.

Slater RE, Strom JG, Granzier H.

J Mol Cell Cardiol. 2017 Jul;108:24-33. doi: 10.1016/j.yjmcc.2017.04.006. Epub 2017 May 3.


Effects of activation on the elastic properties of intact soleus muscles with a deletion in titin.

Monroy JA, Powers KL, Pace CM, Uyeno T, Nishikawa KC.

J Exp Biol. 2017 Mar 1;220(Pt 5):828-836. doi: 10.1242/jeb.139717. Epub 2016 Dec 19.


Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin.

Powers K, Nishikawa K, Joumaa V, Herzog W.

J Exp Biol. 2016 May 1;219(Pt 9):1311-6. doi: 10.1242/jeb.132027. Epub 2016 Mar 4.


Antisense-mediated exon skipping: a therapeutic strategy for titin-based dilated cardiomyopathy.

Gramlich M, Pane LS, Zhou Q, Chen Z, Murgia M, Schötterl S, Goedel A, Metzger K, Brade T, Parrotta E, Schaller M, Gerull B, Thierfelder L, Aartsma-Rus A, Labeit S, Atherton JJ, McGaughran J, Harvey RP, Sinnecker D, Mann M, Laugwitz KL, Gawaz MP, Moretti A.

EMBO Mol Med. 2015 May;7(5):562-76. doi: 10.15252/emmm.201505047.


Shiver me titin! Elucidating titin's role in shivering thermogenesis.

Taylor-Burt KR, Monroy J, Pace C, Lindstedt S, Nishikawa KC.

J Exp Biol. 2015 Mar;218(Pt 5):694-702. doi: 10.1242/jeb.111849. Epub 2015 Jan 8.


Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling.

Hutchinson KR, Saripalli C, Chung CS, Granzier H.

J Mol Cell Cardiol. 2015 Feb;79:104-14. doi: 10.1016/j.yjmcc.2014.10.020. Epub 2014 Nov 8.


Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics.

Elhamine F, Radke MH, Pfitzer G, Granzier H, Gotthardt M, Stehle R.

J Cell Sci. 2014 Sep 1;127(Pt 17):3666-74. doi: 10.1242/jcs.141796. Epub 2014 Jun 30.


Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation.

Chen MP, Li SN, Lam WW, Ho YC, Ha SY, Chan GC, Cheung YF.

BMC Cardiovasc Disord. 2014 Apr 12;14:49. doi: 10.1186/1471-2261-14-49.


Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice.

Hidalgo C, Saripalli C, Granzier HL.

Arch Biochem Biophys. 2014 Jun 15;552-553:100-7. doi: 10.1016/ Epub 2014 Mar 3.


Of cilia, titin, and neurosteroids.

Adler EM.

J Gen Physiol. 2014 Feb;143(2):137-8. doi: 10.1085/jgp.201411161. Review. No abstract available.


Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL.

Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24.


Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

Anderson BR, Bogomolovas J, Labeit S, Granzier H.

J Biol Chem. 2013 Feb 22;288(8):5303-15. doi: 10.1074/jbc.M112.401372. Epub 2013 Jan 6.


Calcium sensitivity and myofilament lattice structure in titin N2B KO mice.

Lee EJ, Nedrud J, Schemmel P, Gotthardt M, Irving TC, Granzier HL.

Arch Biochem Biophys. 2013 Jul 1;535(1):76-83. doi: 10.1016/ Epub 2012 Dec 14.


Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.

Nedrud J, Labeit S, Gotthardt M, Granzier H.

Biophys J. 2011 Sep 21;101(6):1385-92. doi: 10.1016/j.bpj.2011.06.054. Epub 2011 Sep 20.


Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction.

Hudson B, Hidalgo C, Saripalli C, Granzier H.

Circ Res. 2011 Sep 30;109(8):858-66. doi: 10.1161/CIRCRESAHA.111.246819. Epub 2011 Aug 11.


Titin based viscosity in ventricular physiology: an integrative investigation of PEVK-actin interactions.

Chung CS, Methawasin M, Nelson OL, Radke MH, Hidalgo CG, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2011 Sep;51(3):428-34. doi: 10.1016/j.yjmcc.2011.06.006. Epub 2011 Jun 16.


Titin visualization in real time reveals an unexpected level of mobility within and between sarcomeres.

da Silva Lopes K, Pietas A, Radke MH, Gotthardt M.

J Cell Biol. 2011 May 16;193(4):785-98. doi: 10.1083/jcb.201010099. Epub 2011 May 9.


Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.

Chung CS, Granzier HL.

J Mol Cell Cardiol. 2011 Apr;50(4):731-9. doi: 10.1016/j.yjmcc.2011.01.005. Epub 2011 Jan 19.


Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.

Lee EJ, Peng J, Radke M, Gotthardt M, Granzier HL.

J Mol Cell Cardiol. 2010 Sep;49(3):449-58. doi: 10.1016/j.yjmcc.2010.05.006. Epub 2010 May 23.

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