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Items: 1 to 20 of 289

1.

SYK protects cardiocytes against anoxia and hypoglycemia-induced injury in ischemic heart failure.

Yin G, Yang X, Li Q, Guo Z.

Mol Immunol. 2017 Nov;91:35-41. doi: 10.1016/j.molimm.2017.08.018. Epub 2017 Sep 1.

PMID:
28869869
2.

Syk-Mediated Suppression of Inflammatory Responses by Cordyceps bassiana.

Yang WS, Nam GS, Kim MY, Cho JY.

Am J Chin Med. 2017;45(6):1217-1232. doi: 10.1142/S0192415X17500677. Epub 2017 Aug 22.

PMID:
28830213
3.

Syk Regulates Neutrophilic Airway Hyper-Responsiveness in a Chronic Mouse Model of Allergic Airways Inflammation.

Salehi S, Wang X, Juvet S, Scott JA, Chow CW.

PLoS One. 2017 Jan 20;12(1):e0163614. doi: 10.1371/journal.pone.0163614. eCollection 2017.

4.

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.

Hang L, Blum AM, Kumar S, Urban JF Jr, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV.

J Immunol. 2016 Oct 1;197(7):2948-57. doi: 10.4049/jimmunol.1600063. Epub 2016 Aug 24.

5.

Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury.

Ryan J, Kanellis J, Blease K, Ma FY, Nikolic-Paterson DJ.

Am J Pathol. 2016 Aug;186(8):2032-2042. doi: 10.1016/j.ajpath.2016.04.007. Epub 2016 Jun 17.

PMID:
27322771
6.

The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction.

van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1247-53. doi: 10.1161/ATVBAHA.115.306883. Epub 2016 Apr 21.

7.

The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux.

Yaron JR, Rao MY, Gangaraju S, Zhang L, Kong X, Su F, Tian Y, Glenn HL, Meldrum DR.

Biochem Biophys Res Commun. 2016 Apr 8;472(3):545-50. doi: 10.1016/j.bbrc.2016.03.021. Epub 2016 Mar 9.

8.

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent.

Oosting M, Buffen K, Cheng SC, Verschueren IC, Koentgen F, van de Veerdonk FL, Netea MG, Joosten LAB.

Cytokine. 2015 Dec;76(2):465-472. doi: 10.1016/j.cyto.2015.08.005. Epub 2015 Aug 18.

PMID:
26297607
9.

Spleen tyrosine kinase (Syk) inhibitor fostamatinib limits tissue damage and fibrosis in a bleomycin-induced scleroderma mouse model.

Pamuk ON, Can G, Ayvaz S, Karaca T, Pamuk GE, Demirtas S, Tsokos GC.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 91):S15-22. Epub 2015 Jul 6.

PMID:
26148346
10.

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum JL, Miller YI.

Autophagy. 2015;11(5):785-95. doi: 10.1080/15548627.2015.1037061.

11.

Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Ackermann JA, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz VL.

J Immunol. 2015 May 15;194(10):4650-6. doi: 10.4049/jimmunol.1500461. Epub 2015 Apr 10.

12.

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease.

Flynn R, Allen JL, Luznik L, MacDonald KP, Paz K, Alexander KA, Vulic A, Du J, Panoskaltsis-Mortari A, Taylor PA, Poe JC, Serody JS, Murphy WJ, Hill GR, Maillard I, Koreth J, Cutler CS, Soiffer RJ, Antin JH, Ritz J, Chao NJ, Clynes RA, Sarantopoulos S, Blazar BR.

Blood. 2015 Jun 25;125(26):4085-94. doi: 10.1182/blood-2014-08-595470. Epub 2015 Apr 7.

13.

Syk mediates airway contractility independent of leukocyte function.

Wang X, Khanna N, Wu J, Godri Pollitt K, Evans GJ, Chow CW, Scott JA.

Allergy. 2015 Apr;70(4):429-35. doi: 10.1111/all.12564. Epub 2015 Jan 26.

14.

Syk-induced phosphatidylinositol-3-kinase activation in Epstein-Barr virus posttransplant lymphoproliferative disorder.

Hatton O, Lambert SL, Phillips LK, Vaysberg M, Natkunam Y, Esquivel CO, Krams SM, Martinez OM.

Am J Transplant. 2013 Apr;13(4):883-890. doi: 10.1111/ajt.12137. Epub 2013 Feb 7.

15.

Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells.

Lu Y, Li Y, Seo CS, Murakami M, Son JK, Chang HW.

Food Chem Toxicol. 2012 Dec;50(12):4382-8. doi: 10.1016/j.fct.2012.08.053. Epub 2012 Sep 11.

PMID:
22982805
16.

Effect of locally administered Syk siRNA on allergen-induced arthritis and asthma.

Huang ZY, Kim MK, Kim-Han TH, Indik ZK, Schreiber AD.

Mol Immunol. 2013 Jan;53(1-2):52-9. doi: 10.1016/j.molimm.2012.06.011. Epub 2012 Jul 15.

PMID:
22796951
17.

Syk mediates BCR- and CD40-signaling integration during B cell activation.

Ying H, Li Z, Yang L, Zhang J.

Immunobiology. 2011 May;216(5):566-70. doi: 10.1016/j.imbio.2010.09.016. Epub 2010 Oct 7.

18.

Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation.

Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, Bergstrand S, Lönn D, Cevallos RR, Pereira RM, Lopes UG, Travassos LH, Paiva CN, Bozza MT.

J Biol Chem. 2010 Oct 22;285(43):32844-51. doi: 10.1074/jbc.M110.146076. Epub 2010 Aug 20.

19.

Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion.

Pamuk ON, Lapchak PH, Rani P, Pine P, Dalle Lucca JJ, Tsokos GC.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G391-9. doi: 10.1152/ajpgi.00198.2010. Epub 2010 Jun 3.

20.

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway.

Lin YC, Huang DY, Chu CL, Lin WW.

Mol Immunol. 2010 Apr;47(7-8):1569-78. doi: 10.1016/j.molimm.2010.01.008.

PMID:
20138367

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