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Items: 1 to 20 of 47

1.

Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2.

Pflieger LT, Dansithong W, Paul S, Scoles DR, Figueroa KP, Meera P, Otis TS, Facelli JC, Pulst SM.

Hum Mol Genet. 2017 Aug 15;26(16):3069-3080. doi: 10.1093/hmg/ddx191.

2.

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.

Becker LA, Huang B, Bieri G, Ma R, Knowles DA, Jafar-Nejad P, Messing J, Kim HJ, Soriano A, Auburger G, Pulst SM, Taylor JP, Rigo F, Gitler AD.

Nature. 2017 Apr 20;544(7650):367-371. doi: 10.1038/nature22038. Epub 2017 Apr 12.

3.

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway.

Halbach MV, Gispert S, Stehning T, Damrath E, Walter M, Auburger G.

Cerebellum. 2017 Feb;16(1):68-81. doi: 10.1007/s12311-016-0762-4.

4.

Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations.

Meierhofer D, Halbach M, Şen NE, Gispert S, Auburger G.

Mol Cell Proteomics. 2016 May;15(5):1728-39. doi: 10.1074/mcp.M115.056770. Epub 2016 Feb 5.

5.

Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate.

Fittschen M, Lastres-Becker I, Halbach MV, Damrath E, Gispert S, Azizov M, Walter M, Müller S, Auburger G.

Neurogenetics. 2015 Jul;16(3):181-92. doi: 10.1007/s10048-015-0441-5. Epub 2015 Feb 27.

6.

Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.

Drost J, Nonis D, Eich F, Leske O, Damrath E, Brunt ER, Lastres-Becker I, Heumann R, Nowock J, Auburger G.

J Mol Neurosci. 2013 Sep;51(1):68-81. doi: 10.1007/s12031-012-9949-4. Epub 2013 Jan 19.

7.

Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.

Hansen ST, Meera P, Otis TS, Pulst SM.

Hum Mol Genet. 2013 Jan 15;22(2):271-83. doi: 10.1093/hmg/dds427. Epub 2012 Oct 18.

8.

Dissociated fear and spatial learning in mice with deficiency of ataxin-2.

Huynh DP, Maalouf M, Silva AJ, Schweizer FE, Pulst SM.

PLoS One. 2009 Jul 20;4(7):e6235. doi: 10.1371/journal.pone.0006235.

9.

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.

Nóbrega C, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar UG, Mendonça L, Hirai H, de Almeida LP.

Brain. 2015 Dec;138(Pt 12):3537-54. doi: 10.1093/brain/awv298. Epub 2015 Oct 21.

PMID:
26490332
10.

Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.

Dansithong W, Paul S, Figueroa KP, Rinehart MD, Wiest S, Pflieger LT, Scoles DR, Pulst SM.

PLoS Genet. 2015 Apr 22;11(4):e1005182. doi: 10.1371/journal.pgen.1005182. eCollection 2015 Apr.

11.

Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.

Lastres-Becker I, Brodesser S, Lütjohann D, Azizov M, Buchmann J, Hintermann E, Sandhoff K, Schürmann A, Nowock J, Auburger G.

Hum Mol Genet. 2008 May 15;17(10):1465-81. doi: 10.1093/hmg/ddn035. Epub 2008 Feb 4.

PMID:
18250099
12.

Generation and characterization of Sca2 (ataxin-2) knockout mice.

Kiehl TR, Nechiporuk A, Figueroa KP, Keating MT, Huynh DP, Pulst SM.

Biochem Biophys Res Commun. 2006 Jan 6;339(1):17-24. Epub 2005 Nov 8.

PMID:
16293225
13.

Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice.

Aguiar J, Fernández J, Aguilar A, Mendoza Y, Vázquez M, Suárez J, Berlanga J, Cruz S, Guillén G, Herrera L, Velázquez L, Santos N, Merino N.

Neurosci Lett. 2006 Jan 16;392(3):202-6. Epub 2005 Oct 3.

PMID:
16203087
14.

The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression.

Nechiporuk T, Huynh DP, Figueroa K, Sahba S, Nechiporuk A, Pulst SM.

Hum Mol Genet. 1998 Aug;7(8):1301-9.

PMID:
9668173
15.

Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.

Pfeffer M, Gispert S, Auburger G, Wicht H, Korf HW.

Chronobiol Int. 2017;34(1):129-137. doi: 10.1080/07420528.2016.1245666. Epub 2016 Oct 28.

PMID:
27791392
16.

Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.

Sen NE, Drost J, Gispert S, Torres-Odio S, Damrath E, Klinkenberg M, Hamzeiy H, Akdal G, Güllüoğlu H, Başak AN, Auburger G.

Neurobiol Dis. 2016 Dec;96:115-126. doi: 10.1016/j.nbd.2016.09.002. Epub 2016 Sep 3.

PMID:
27597528
17.

ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.

Damrath E, Heck MV, Gispert S, Azizov M, Nowock J, Seifried C, Rüb U, Walter M, Auburger G.

PLoS Genet. 2012;8(8):e1002920. doi: 10.1371/journal.pgen.1002920. Epub 2012 Aug 30.

18.

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

Pulst SM, Nechiporuk A, Nechiporuk T, Gispert S, Chen XN, Lopes-Cendes I, Pearlman S, Starkman S, Orozco-Diaz G, Lunkes A, DeJong P, Rouleau GA, Auburger G, Korenberg JR, Figueroa C, Sahba S.

Nat Genet. 1996 Nov;14(3):269-76.

PMID:
8896555
19.
20.

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.

Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inoue M, Katayama S, Kawakami H, Nakamura S, Nishimura M, Akiguchi I, et al.

Nat Genet. 1994 Nov;8(3):221-8.

PMID:
7874163

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